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Colorectal cancer (CRC) is the third most common cancer worldwide. Increasing evidence suggests that CRC should be considered a heterogeneous disease, with multiple differences between proximal and distal tumours. The immune system may, depending on the context, promote or inhibit tumour growth, and different immune cell subsets have been found to be associated with impaired or improved prognosis
Abstract Noroviruses are now the leading cause of gastroenteritis worldwide. Noroviruses are effectively transmitted due to a low infectious dose, viral shedding in high concentrations, environmental stability, and they induce only a limited immunity after infection. Especially, the norovirus variants of genotype II.4 (GII.4) have seemed greatly adapted for pandemic spread. The high infectivity o
The incidence of narcolepsy type 1 (NT1) increased in Sweden following the 2009-2010 mass-vaccination with the influenza Pandemrix-vaccine. NT1 has been associated with Human leukocyte antigen (HLA) DQB1*06:02 but full high-resolution HLA-typing of all loci in vaccine-induced NT1 remains to be done. Therefore, here we performed HLA typing by sequencing HLA-DRB3, DRB4, DRB5, DRB1, DQA1, DQB1, DPA1
Background: Screening that includes digital breast tomosynthesis (DBT) with two-dimensional (2D) synthetic mammography (SM) or standard 2D digital mammography (DM) results in detection of more breast cancers than does screening with DM alone. A decrease in interval breast cancer rates is anticipated but is not reported. Purpose: To compare rates and characteristics of (a) interval breast cancer in
Rationale & Objective: Data for outcomes of patients with end-stage renal disease (ESRD) secondary to systemic sclerosis (scleroderma) requiring renal replacement therapy (RRT) are limited. We examined the incidence and prevalence of ESRD due to scleroderma in Europe and the outcomes among these patients following initiation of RRT. Study Design: Registry study of incidence and prevalence and
Denna avhandling undersöker vetenskapens roll i den politiska processens tidiga stadier. Detta görs genom att studera hur "geoengineering" kommer upp på den politiska agendan. Begreppet ”geoengineering” används även på svenska och beskriver en uppsättning idéer om hur man stabiliserar den globala temperaturen genom att ingripa i jordens miljösystem. Begreppet mötte stark skepsis i det vetenskapligThis thesis examines the role of science in the earliest stages of the political process. It does this by studying the emergence of ‘geoengineering’ on the political agenda. The term describes a set of ideas on how to stabilize global temperature by intervening into the Earth’s natural systems, and was subject to a strong taboo in the scientific community until the mid-2000s. Yet within a decade,
Lung cancer is a common cancer type associated with poor prognosis. Even in the group of patients with earlystage tumors, for which curative treatment is possible, lung cancer recurrence is frequent. The aim of this thesis was to investigate the potential prognostic role of mutations in tumor specimens, blood-based proteins and circulating tumor DNA.In study I, we performed EGFR mutation detection
Objective: To investigate the causal role of cardiometabolic risk factors in osteoarthritis (OA) using associated genetic variants. Methods: We studied 27,691 adults from the Malmö Diet and Cancer Study (MDCS) and replicated novel findings among 376,435 adults from the UK Biobank. Trait-specific polygenic risk scores for low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol
LUM Lunds universitets magasin | Nr 2 | 2011 omsvärmad LU startar stiftelse i USA Klassfrågan het igen... 2 LUM nr 2 | 2011 1947 års kvinna Ovan: Ett tidigt självporträtt (1943) som Randi Fisher gav bort i lysningspresent till sin syster Else inför giftermålet med Ingmar Bergman. Till höger: En vävd kormatta som lånats av Askersunds församling (1955). En detaljskiss till teaterridån i Medborgarhus
https://www.lu.se/sites/www.lu.se/files/lunds-universitets-magasin-2-2011.pdf - 2026-07-22
Background: Myocardium at risk (MaR) can be evaluated by cardiovascular magnetic resonance (CMR) imaging using contrast-enhanced steady state free precession (CE-SSFP) in patients after ST-elevation myocardial infarction (STEMI). However, CE-SSFP utilizes gadolinium contrast, which is contraindicated in patients with severe renal insufficiency. Native T1-mapping is a non-contrast CMR method which
Background and objective: Patients diagnosed with grade group (GG) 1 prostate cancer (PCa) following treatment for benign disease (“incidental” PCa) are typically managed with active surveillance (AS). It is not known how their outcomes compare with those observed in patients diagnosed with GG1 on biopsy. We aimed at determining whether long-term oncologic outcomes of AS for patients with GG1 PCa
Importance: Early identification of the likelihood of autism spectrum disorder (ASD) using minimal information is crucial for early diagnosis and intervention, which can affect developmental outcomes. Objective: To develop and validate a machine learning (ML) model for predicting ASD using a minimal set of features from background and medical information and to evaluate the predictors and the util
BACKGROUND: Sacroiliac joint pain is increasingly recognized as a cause of low back pain. We compared the safety and effectiveness of minimally invasive sacroiliac joint arthrodesis using triangular titanium implants and conservative management in patients with chronic sacroiliac joint pain. METHODS: This study was a prospective, multicenter randomized controlled trial of adults with chronic sacro
Uppsatsmall MELLAN DELTAGANDE OCH INFLYTANDE En kartläggning av brukarråd i Skånes kommuner HÅKAN JOHANSSON, LINN JOHANSSON & ROBERTO SCARAMUZZINO MEDDELANDE FRÅN SOCIALHÖGSKOLAN, LUNDS UNIVERSITET, 2011:3 Mellan deltagande och inflytande: En kartläggning av brukarråd i Skånes kommuner Håkan Johansson, Linn Johansson & Roberto Scaramuzzino Meddelande från Socialhögskolan, Lunds universitet, 2011:3
https://www.soch.lu.se/sites/soch.lu.se/files/ms2011-3_0.pdf - 2026-07-22
Review https://doi.org/10.1038/s41586-018-0087-1 New approaches for brain repair—from rescue to reprogramming Roger A. Barker1*, Magdalena Götz2,3* & Malin Parmar4* The ability to repair or promote regeneration within the adult human brain has been envisioned for decades. Until recently, such efforts mainly involved delivery of growth factors and cell transplants designed to rescue or replace a sp
https://www.regenerative-neurobiology.lu.se/sites/regenerative-neurobiology.lu.se/files/barker_nature.pdf - 2026-07-22
GENERAL AIM: To investigate how common single-nucleotide-polymorphisms (SNPs) that associate with cardiovascular disease (CVD) could be used in prevention and treatment of CVD. SUBJECTS: Subjects from the population-based Malmö-Diet-and-Cancer-(MDC)-Study (n=30447) and hypertensives from the Nordic-Diltiazem-(NORDIL)-Study (n=10881). METHODS AND RESULTS: A nine-SNP-lipid-genetic-risk-score was r
Peak aerobic power in humans ((V) over dot(O2), peak) is markedly affected by inspired O-2 tension (F-IO2). The question to be answered in this study is what factor plays a major role in the limitation of muscle peak. (V) over dot(O2) in hypoxia: arterial O-2 partial pressure (P-a,(O2)) or O-2 content (C-a,C-O2)? Thus, cardiac output (dye dilution with Cardio-green), leg blood flow (thermodilution
BACKGROUND & AIMS: Little is known about recurrence of pancreatitis after an initial episode, and little is known about how the disease progresses or what factors affect progression. We performed a population-based study of patients with acute pancreatitis (AP) to determine their outcomes and associated factors. METHODS: We performed a retrospective study of patients with first-time AP from 20
Objective To compare, in young active adults with an acute anterior cruciate ligament (ACL) tear, the mid-term (five year) patient reported and radiographic outcomes between those treated with rehabilitation plus early ACL reconstruction and those treated with rehabilitation and optional delayed ACL reconstruction. Design Extended follow-up of prospective randomised controlled trial. Setting Ortho
