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Background and Objectives The aim of this study was to evaluate the pharmacokinetics, efficacy and safety of a newly developed 10% liquid immunoglobulin preparation in patients with primary immunodeficiency diseases. This new preparation for intravenous use includes three dedicated virus clearance steps in its manufacturing process to ensure a high margin of viral safety. Materials and Methods Thi
This study investigates the efficacy of tumor radioimmunotargeting with 125I-labeled BR96-biotin monoclonal antibody using a new method, whole-blood immunoadsorption (WBIA), based on direct adsorption of unbound monoclonal antibody (MAb) from blood without preceding separation of plasma. METHODS: Highly tumor-reactive, internalizing, chimeric BR96 MAb of isotype IgG1 binds to a tumor-associated Le
Popular Abstract in Swedish Populärvetenskaplig sammanfattning Introduktion Adrenokortikotropiskt hormon (ACTH) stimulerar frisättningen av steroid¬hormoner, främst kortisol, från binjurarna. Kortisol är livsnödvändigt och finns alltid i blodet och förhöjs kraftigt vid stress. I början av 90-talet fann vår forskningsgrupp en koppling mellan ACTH och fettomsättningen som inte involverade steroidh
Aims: A study was undertaken to examine whether poor self-rated health (SRH) can independently predict all-cause mortality during 22-year follow-up in middle-aged men and women. Subjects and methods: Data are derived from a population-based study in Malmo¨ , Sweden. This included baseline laboratory testing and a self-administered questionnaire. The question on global SRH was answered by 15,590 me
Effects of introducing a carbonyl group into the conjugation system of carotenoids were studied for four naturally occurring carotenoids: peridinin, fucoxanthin, siphonaxanthin and spheroidenone. The conjugated carbonyl group affects energetics and dynamics of all these carotenoids in a similar way, although the magnitude of the changes depends strongly on the carotenoid structure. Firstly, presen
Superporous agarose beads contain two sets of pores, diffusion pores and so-called superpores or flow pores, in which the chromatographic flow can transport substances to the interior of each individual bead [Gustavsson and Larsson, J. Chromatogr. A 734 (1996) 231]. The existence of pore flow may be proven indirectly by the chromatographic performance of beads but it has never been directly demons
The regional sensitivity of different vascular beds to i.v. CGRP was investigated in the albino rabbit by using the microsphere method. Experiments were performed without pre-treatment on both conscious and pentobarbital-anaesthetized animals. In addition, in one series on conscious animals, rabbits were pre-treated with indomethacin in order to reduce the formation of prostaglandins. In another s
Förevarande text handlar om skillnaderna mellan äktenskapsförord och förmögenhetsrättsliga avtal. Ett äktenskapsförord är ett familjerättsligt avtal med stark förmögenhetsrättslig prägel. Detta till trots gör sig dock en del typiska familjerättsliga särdrag gällande. Sådana särdrag är exempelvis de olika formkrav som gör sig gällande ifråga om äktenskapsförord. Äktenskapsförord skall upptecknas i This text is about the various differences between prenuptial agreements and contracts dealing with property law. A prenuptial agreement is a contract between partners, with strong economical characteristics. In spite of these characteristics there are some essential differences between the two types of contracts. There are, for instance, more formal requirements to take into consideration concern
A change in legislation has resulted in that many of Sweden’s municipal landfills were closed in the beginning of this century. After landfill completion, the oper-ator is responsible for at least 30 years to take action with regard to the protec-tion of human health and the Environment. In contribution Swedish landfill owners are facing increasing demands on local leachate treatment due to a chan
Nearly all mammalian cells express a set of genes known as clock genes. These regulate the circadian rhythm of cellular processes by means of negative and positive autoregulatory feedback loops of transcription and translation. Recent genomewide association studies have demonstrated an association between a polymorphism near the circadian clock gene CRY2 and elevated fasting glucose. To determine
The aim of this multicenter study was to investigate whether a computer-assisted diagnosis (CAD) system could improve performance and reduce interobserver variation in bone-scan interpretations of the presence or absence of bone metastases. Methods: The whole-body bone scans (anterior and posterior views) of 59 patients with breast or prostate cancer who had undergone scintigraphy for suspected bo
Objective: To determine the interobserver agreement (IOA) of neonatal seizure detection using the gold standard of conventional, multichannel EEG. Methods: A cohort of full-term neonates at risk of acute encephalopathy was included in this prospective study. The EEG recordings of these neonates were independently reviewed for seizures by three international experts. The IOA was estimated using sta
The Universal Thermal Climate Index (UTCI) aimed for a one-dimensional quantity adequately reflecting the human physiological reaction to the multi-dimensionally defined actual outdoor thermal environment. The human reaction was simulated by the UTCI-Fiala multi-node model of human thermoregulation, which was integrated with an adaptive clothing model. Following the concept of an equivalent temper
Dangdut as the most popular music in Indonesia is highly sexualized on its representation of women despite the fact that Indonesia is a religious country. Dangdut’s sexualization is prominent on its performance, lyrics and culture. Banality, is the face of dangdut. During its public shows, many of the male audiences are more often than not intoxicated and engage in physical fights. Yet to date, th
All viruses are composed of both genetic material and a capsid. The capsid is composed by identical protein subunits and the purpose is protection of the genetic material, in this case RNA. This project is about cowpea chlorotic mottle virus, also called CCMV, which is a plant virus and the disassembly and reassembly mechanisms of the capsid are investigated to understand how the capsid proteins a
Microalgae belong to the group of the oldest microorganisms that can grow in both fresh and marine water. Microalgal biomass is a rich source of vitamins, lipids, pigments and essential amino acids. Microalgal biomass can be used without cracking and fractionation or it can be cracked, fractionated and purified to get particular components like vitamins, pigments, omega-3 oils and proteins. But du
Synnerligen grov misshandel är en brottstyp som introducerades i svensk straffrätt år 2010, detta efter att regeringen uttryckt att straffskärpningar behövdes då man inte ansåg att de utdömda straffen var proportionerliga i förhållande till brottets allvar. Flertalet fall har sedermera hamnat i HD och hovrätterna och en praxis har skapats kring vad brottet innebär. Stort fokus läggs på hänsynslöshExceptional aggravated assault is a crime which was introduced to Swedish criminal law in 2010. The reason behind this was the fact that the Swedish government believed that harsher punishments were needed due to the fact that they were not proportional in comparison to the seriousness of the crime. Regarding what is to be considered as exceptional aggravated assault, the courts tend to focus on t
This study aims to investigate the possibility of creating template times for rail works. Furthermore the study identifies a few effects which template times could have on planning of rail works, traffic and economy. Template times are being considered by the Swedish Transport Administration, Trafikverket, for the early stages of planning when there is a need to estimate the time required within t
I samband med Covid-19-pandemins inträffande tvingades såväl allmänna domstolar som skiljenämnder världen över att ta ställning till om förhandlingar skulle ställas in i väntan på att smittspridningen skulle gå ner eller om de skulle genomföras med hjälp av tekniska hjälpmedel. Många var snabba med att utnyttja de tekniska möjligheter som stod till buds och det blev på kort tid vanligt med virtuelWith the onset of the Covid-19 pandemic, national courts and arbitration tribunals around the world were forced to decide whether to cancel hearings while waiting for the spread of the disease to subside, or whether to conduct them using technical means. Many were quick to take advantage of the technological means available, and virtual hearings in which all participants are present via some form
Things such as organizations, persons, or locations are ubiquitous in all texts circulating on the internet, particularly in the news, forum posts, and social media. Today, there is more written material than any single person can read through during a typical lifespan. Automatic systems can help us amplify our abilities to find relevant information, where, ideally, a system would learn knowledge
