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Background Long-term outcome after hematopoietic stem cell transplantation including late transplant-related events is of increasing interest. The aim of this study was to evaluate the incidence of cardiovascular events after allogeneic HSCT and to search for their risk factors. Design and Methods This is a retrospective mutlicenter European Group of Blood and Marrow Transplantation (EBMT) analysi

Electrode grounding resistance is a major factor affecting measurement quality in electric resistivity tomography (ERT) measurements for cryospheric applications. Still, little information is available on grounding resistances in the geophysical literature, mainly because it is difficult to measure. The focus-one protocol is a new method for estimating single electrode grounding resistances by mea

Anti-neutrophil cytoplasmic antibodies (ANCAs) have a pathogenic role in ANCA-associated vasculitis. The origin of ANCAs and anti-glomerular basement membrane (GBM) antibodies, however, is unknown. In this study, we determined whether natural autoantibodies against myeloperoxidase (MPO), proteinase 3 (PR3), and GBM were present in each of 10 healthy Chinese and Swedish individuals, negative for al

We investigated the immunosuppressive effects of the dihydroortate dehydrogenase (DHODH) inhibitor compounds ABR-222417 and ABR-224050 from Active Biotech (Sweden). We verified the inhibitory effects of these compounds on the proliferation of CD4(+) and CD8(+) T-cells in vivo by using superantigen staphylococcus enterotoxin A (SEA)-mediated proliferation test. To evaluate their efficacy, the compo

Recurrent gastrointestinal bleeding is one of the most challenging complications encountered in the management of patients with von Willebrand disease (VWD). The commonest cause is angiodysplasia, but often no cause is identified due to the difficulty in making the diagnosis. The optimal treatment to prevent recurrences remains unknown. We performed a retrospective study of VWD patients with occul

AimsWe recently identified a metabolic signature of three amino acids (tyrosine, phenylalanine, and isoleucine) that strongly predicts diabetes development. As novel modifiable targets for intervention are needed to meet the expected increase of cardiovascular disease (CVD) caused by the diabetes epidemic, we investigated whether this diabetes-predictive amino acid score (DM-AA score) predicts dev

Background: Chronic depression is a particularly disabling mood disorder and treatment outcomes are poor with either psychotherapy or pharmacotherapy alone. There is growing evidence that an integrative treatment approach may be optimal. A novel multi-modal, multi-disciplinary treatment program, Re-ChORD, was developed at the University of British Columbia and evaluated in this pilot study. Method

Environmental exposure to cadmium (Cd) is known to induce oxidative stress, a state of imbalance between the production of reactive oxygen species (ROS) and the ability to detoxify them, in adults. However, data are lacking on potential effects in early-life. We evaluated urinary concentrations of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG), a recognized marker of oxidative DNA damage, in relati

Socioeconomic shocks can shape future land-use trajectories. Armed conflicts are an extreme form of a socioeconomic shock, but our understanding of how armed conflicts affect land-use change is limited. Our goal was to assess land-use changes related to the 1991–1994 Nagorno-Karabakh conflict between Armenia and Azerbaijan in the Caucasus region. We classified multi-temporal Landsat imagery, mappe

The aim of this study was to evaluate the relationship between respiratory symptoms, lung function and inflammatory markers in 'healthy' smokers. The study population was recruited from an epidemiological study with subjects of the same age, 60 years. Only smokers who considered themselves healthy (n=58) and a random sample of never-smokers (n=34) were investigated. All subjects underwent lung fun

Popular Abstract in Swedish Den fysiska planeringen innebär interaktion mellan aktörer inom skilda samhällssfärer där parter med skilda sociala positioner, resurser, perspektiv och värderingar möts. Aktörernas bilder av vilka effekter ett givet planförslag medför och vilka effekter som ska betraktas som de mest centrala varierar regelmässigt. Mellan de berörda parterna är det därför inte ovanligt Since planning in connection with new building projects frequently generates controversy, it can be seen as a typical form of contentious politics. The aim of this dissertation is to analyze siting controversies, their origin, development and termination, in efforts to explore the problem of legitimacy in planning processes of this sort. The research approach employed is that of a multiple case s

Popular AbstractDen nya världsordningen som Castells kallar för nätverksamhälle skapar en konflikt mellan globalisering och identitet. I detta avseende blir frågan om identitet och etniska gränser, i Barths mening, ett centralt tema för att förstå samhällsförändringar. Globaliseringsprocessen håller på att skapa en försvagning av det civila samhället och med detta försvagas också förhållandena melThe new world order, that Castells denominates network society, generates a conflict between the globalisation and identity. In this sense the questions of identity and ethnic boundaries,in Barth’s meaning, emerge as a central subject to understanding societal changes. Globalisation is causing a weakening of the civil society, the relationship between the nation state and the people is also debili

Popular Abstract in Swedish Syftet med denna avhandling är att studera hur sagor kan förändras när de förflyttas från en miljö till en annan. Flytten kan ske på flera plan; från muntligt berättande till skriftlig text, från lantligt proletariat till urban borgerlighet. Utgångspunkt har varit sagoinsamlaren och sagoförfattarens Eva Wigström (1832-1901) som på 1880-talet vandrade Skåne runt för att The purpose of this thesis is to study how fairy tales can change when they are removed from one set of surroundings to another. This movement can occur on several levels; from an orally spoken to a written text, from a rural proletariat to an urban bourgeoisie. The point of departure has been the fairy tale collector and fairy tale writer Eva Wigström (1832-1901) who in the 1880s wandered through

Background: Hyper- as well as hypoglycemia may be detrimental for brain energy metabolism and even a moderate increase in blood glucose concentration can affect outcome adversely. During physiological conditions, glucose concentration obtained from microdialysis of subcutaneous adipose tissue adequately reflects plasma glucose concentration. This study examines whether this correlation is also obt

PURPOSE: To elucidate the role of leucine-rich proteoglycans lumican and fibromodulin in the sclera. METHODS: Lumican- and fibromodulin-null heterozygous mice were intercrossed to obtain wild-type (Lum(+/+)Fmod(+/+)), lumican-null (Lum(-/-)Fmod(+/+)), fibromodulin-null (Lum(+/+)Fmod(-/-)), and double-null (Lum(-/-)Fmod(-/-)) littermates. Axial length was measured on enucleated whole eyes, and ocul

Objective: To describe anthropometric characteristics of participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). Design: A cross-sectional analysis of baseline data of a European prospective cohort study. Subjects: This analysis includes study populations from 25 centres in nine European countries. The British populations comprised both a population-based and a 'he

Many economic models contain the single variable 'money'. Money does not exist in the form of a single physical unit and it is common to construct monetary aggregates using the method of simple summations. Monetary aggregation theory lends little or no support to the method of simply summing various monetary asset components up to arbitrary levels of aggregation. In monetary aggregation theory, mo

In a 5-year study involving 119 postmenopausal women, zoledronic acid 4 mg given once-yearly for 2, 3 or 5 years was well tolerated with no evidence of excessive bone turnover reduction or any safety signals. BMD increased significantly. Bone turnover markers decreased from baseline and were maintained within premenopausal reference ranges. Introduction After completion of the core study, two cons

The objective of this study was to evaluate the efficacy of low dose dehydroepiandrosterone (DHEA) on health-related quality of life (HRQOL) in glucocorticoid treated female patients with systemic lupus erythematosus (SLE). Forty one women (>= 5 mg prednisolone/day) were included in a double-blind, randomized, placebo-controlled study for 6 months where DHEA was given at 30 mg/20 mg (<= 45/>= 46 y

The etiology of exercise-induced rib stress fractures (RSFs) in elite rowers is unclear. The purpose of the study was to investigate thoracic muscle activity, movement patterns and muscle strength in elite rowers. Electromyographic (EMG) and 2-D video analysis were performed during ergometer rowing, and isokinetic muscle strength was measured in seven national team rowers with a history of RSF and