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The potential effects of oral contraceptive (OC) and postmenopausal hormone (PMH) use are not well understood among BRCA1 or BRCA2 (BRCA1/2) deleterious mutation carriers with a history of breast cancer. We investigated the association between OC and PMH use and risk of contralateral breast cancer (CBC) in the WECARE (Women's Environment, Cancer, and Radiation Epidemiology) Study. The WECARE Study
Neuroblastomas (NBs) are tumours of the sympathetic nervous system accounting for 8-10% of paediatric cancers. NBs exhibit extensive intertumour genetic heterogeneity, but their extent of intratumour genetic diversity has remained unexplored. We aimed to assess intratumour genetic variation in NBs with a focus on whole chromosome changes and their underlying mechanism. Allelic ratios obtained by S
Qualitative measurements of both OH and polycyclic aromatic hydrocarbons (PAH) as well as quantitative data of soot volume fraction f(v) have been obtained in vaporized liquid fuels, with the main goal of providing experimental data for combustion models and numerical mechanism validation. Measurements were carried out in a laminar coflow burner which was designed, built and integrated with an eva
This thesis consists of three essays on VIX futures and options, and deals with issues highly relevant to all financial markets, such as understanding the operation of markets and developing flexible and tractable pricing models for contracts traded in them. It consists of four chapters. Chapter 1 provides a short introduction to the VIX and a brief explanation of how the old and new VIX are cons
Stretch of vascular smooth muscle stimulates growth and proliferation as well as contraction and expression of contractile/cytoskeletal proteins, all of which are also regulated by calcium-dependent signals. We studied the role of the calcium- and integrin-activated proline-rich tyrosine kinase 2 (PYK2) in stretch-induced responses of the rat portal vein loaded by a hanging weight ex vivo. PYK2 ph
Thesis purpose: to develop theory that can explain the contradictions that we see in contemporary society in the choice of cooking salt. Salt consumption can cause severe health problems. Consumers in the middle and upper classes are health aware, but seem to have other motivations for their choice in cooking salt. As appears in the hype that we see around cooking salt and the increased specialisa
The aim of this thesis is to better understand Hindu-Christian relations in the experience of North Indian Pentecostals. The study proceeds from a social identity theory (SIT) framework and is guided by three research questions. The research questions call attention to Pentecostals’ perception of the two social groups ‘Christians’ and ‘Hindus’, how the relationship between the two groups is experi
Popular science summary: Transcriptional regulation of HIF-2α in neuroblastoma Neuroblastoma is the most common solid tumor in childhood. The presence of hypoxia -regions of low levels of oxygen- causes a more immature tumor phenotype that is related to a more aggressive form of this cancer. Hypoxia is mainly directed by Hypoxia Inducible Factors (HIF)-1α and HIF-2α. High levels of HIF-2α expre
I en allt mer globaliserad värld präglad av konstant gränsöverskridande handel är det av yttersta vikt att beskattningen av gränsöverskridande transaktioner fungerar tillfredsställande. Detta gäller även de fall då avkastning på finansiella instrument korsar länders gränser. I svensk rätt liksom i många andra länders rätt saknas klara definitioner för vad som är ränta och vad som är utdelning. DetIn a progressively more globalized world featuring constant cross-border trade it is imperative that the taxation of cross-border transactions is carried out in a satisfactory manner. This is also true regarding periodic income from financial instruments. In Swedish tax law as well as in many other countries there is no clear definition of what constitutes interest and dividends. Large multination
Denna uppsats behandlar restriktioner för utländskt ägande i aktiebolag i Förenade Arab Emiraten (UAE). Till en början kommer studien att guida oss genom en översikt av bolagsetablering samt bolagsstrukturer i landet, vilket sedermera leder till att specificera skillnaderna mellan frizon och fastland. Följaktligen avgränsas studien för att snävare fokusera på aktiebolag i fastlandet. Här presenterThis essay covers the subject of foreign ownership restrictions in LLCs in UAE mainland. In the beginning the study will guide us through an overview of the incorporation process and recognized company structures, which further specifies the differences between free zone and mainland. Accordingly, the study narrows down to focus on mainland LLCs, where the 49/51 rule, which restricts foreign inves
Barnhandel är rekrytering, transport, överföring, inhysande eller mottagande av ett barn i syfte att exploatera hen. I Sverige, som i första hand är ett destinationsland för barnhandel, identifieras ett 50-tal barn per år som offer för människohandel. Antalet okända fall uppges dock vara betydligt högre. Med barn re-trafficking avses varje situation där ett barn som har brutit sig loss från en mänChild trafficking is the recruitment, transportation, transfer, harbouring, or receipt of a child for the purpose of exploitation. In Sweden, which primarily is a country of destination for child trafficking, around 50 children per year are identified as child victims of human trafficking. However, the number of unknown cases is said to be significantly higher. Child re-trafficking means any situa
Att byggsektorn står inför ett rådande klimatnödläge är ett faktum. Idag investeras hundratals miljarder kronor för att i framtiden kunna producera fossilfritt stål; trots det läggs lite fokus på miljöoptimering av konstruktioner. Syftet med arbetet är att utvärdera hur parametrisk design kan användas som verktyg för att miljöoptimera stålstommar i industritrapptorn samt undersöka vilken profiltypThe fact that the construction sector faces a prevailing climate emergency is undeniable. Today, hundreds of billions of kronor are being invested to develop fossil-free steel; yet little focus is placed on environmental optimization of constructions. The purpose of this work is to evaluate how parametric design can be used as a tool for environmental optimization of steel staircase towers, as wel
Synnerligen grov misshandel är en brottstyp som introducerades i svensk straffrätt år 2010, detta efter att regeringen uttryckt att straffskärpningar behövdes då man inte ansåg att de utdömda straffen var proportionerliga i förhållande till brottets allvar. Flertalet fall har sedermera hamnat i HD och hovrätterna och en praxis har skapats kring vad brottet innebär. Stort fokus läggs på hänsynslöshExceptional aggravated assault is a crime which was introduced to Swedish criminal law in 2010. The reason behind this was the fact that the Swedish government believed that harsher punishments were needed due to the fact that they were not proportional in comparison to the seriousness of the crime. Regarding what is to be considered as exceptional aggravated assault, the courts tend to focus on t
The aim of the study was to perform a hazard assessment of ingredients in sunscreen products available on the Swedish market. Data was collected by documentation of all ingredients in 110 frequently occurring sunscreen products from 15 different brands and by a screening of four known databases for collection of hazard classifications of the ingredients. The study shows that 96 out of 347 ingredie
I ett samhälle där bilismen ökar blir en mer hållbar bilism allt viktigare. Sverige har satt upp som mål att ha en fossiloberoende fordonsflotta till 2030 och en helt fossilfri fordonsflotta till 2050. För att kunna uppnå detta spelar elbilen en viktig roll. Genom intervjuer med olika aktörer på den svenska marknaden visas i detta examensarbete att en stor tilltro sätts till elbilen, vid sidan av In a society with growing car mobility, sustainable motorism becomes increasingly important. Sweden has set targets of having a fossil fuel independent vehicle fleet by 2030 and a fossil free vehicle fleet by 2050.In order to reach these targets the electric car plays an important role. Through interviews with different actors on the Swedish market, this thesis shows that much confidence is put in
I dagsläget äger nästan alla vuxna svenskar finansiella instrument. Det är vidare allmänt känt att sparande i finansiella instrument inte är helt riskfritt. För många individer är besparingarna väldigt viktiga, samtidigt som många saknar den kunskap som krävs för att investera i finansiella instrument. Behovet av finansiell rådgivning har därför ökat kraftigt, varför det får anses oroväckande att
Vätgas är en energibärare som kan ha en roll i fossilfria energisystem. I det här examensarbetet undersöktes därför den praktiskt genomförbara potentialen för förnybar vätgas att göra nytta i Skånes energisystem inom tidsramen till 2030. Detta analyserades genom en undersökning av de tekniska och regionala förutsättningarna för förnybar vätgas, en intervjustudie med sju skånska vätgasaktörer, samtHydrogen is an energy carrier that could be a part of fossil free energy systems. That is why the practicable potential of renewable hydrogen to benefit the energy system of Scania, Sweden, within the time frame of until 2030 was evaluated in this report. This was done through reviewing the technical and regional conditions and through interviews with seven regional actors involved in hydrogen, as
Dangdut as the most popular music in Indonesia is highly sexualized on its representation of women despite the fact that Indonesia is a religious country. Dangdut’s sexualization is prominent on its performance, lyrics and culture. Banality, is the face of dangdut. During its public shows, many of the male audiences are more often than not intoxicated and engage in physical fights. Yet to date, th
This study aims to investigate the possibility of creating template times for rail works. Furthermore the study identifies a few effects which template times could have on planning of rail works, traffic and economy. Template times are being considered by the Swedish Transport Administration, Trafikverket, for the early stages of planning when there is a need to estimate the time required within t
I samband med Covid-19-pandemins inträffande tvingades såväl allmänna domstolar som skiljenämnder världen över att ta ställning till om förhandlingar skulle ställas in i väntan på att smittspridningen skulle gå ner eller om de skulle genomföras med hjälp av tekniska hjälpmedel. Många var snabba med att utnyttja de tekniska möjligheter som stod till buds och det blev på kort tid vanligt med virtuelWith the onset of the Covid-19 pandemic, national courts and arbitration tribunals around the world were forced to decide whether to cancel hearings while waiting for the spread of the disease to subside, or whether to conduct them using technical means. Many were quick to take advantage of the technological means available, and virtual hearings in which all participants are present via some form
