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Objective To identify predictors of response to methotrexate (MTX) in early rheumatoid arthritis (RA). Methods In the SWEFOT trial, patients with RA with symptom duration <1 year started MTX monotherapy (20 mg/weekly) and 405/487 continued until the 3-4-month visit. The primary outcome measure was the DAS28-based European League against Rheumatism (EULAR) response criteria. Multivariate logistic r
Background: Celiac disease often goes undiagnosed. Mass screening might be an option to reduce the public health burden of untreated celiac disease. However, mass screening is still controversial since it is uncertain whether the benefits of early detection outweigh the possible negative consequences. Before implementation of screening programs, the experiences of those being identified as cases s
Background: Malignant melanoma is the most lethal form of skin cancer with a variable clinical course even in patients with thin melanomas and localized disease. Despite increasing insights into melanoma biology, no prognostic biomarkers have yet been incorporated into clinical protocols. Reduced expression of the RNA binding motif protein 3 (RBM3) has been shown to correlate with tumour progressi
Response of passerine birds to an irruption of a pine processionary moth Thaumetopoea pityocampa population with a shifted phenology The main purpose of the present work was to investigate if the passerine community was able to respond to it localized irruption of a temporally shifted population of the pine processionary moth Thaumetopoea pityocampa, the larval development of which takes place dur
BACKGROUND: Postmenopausal hormone therapy (HRT) and oral contraceptive (OC) use have in several studies been reported to be associated with a decreased colorectal cancer (CRC) risk. However, data on the association between HRT and OC and risk of different clinicopathological and molecular subsets of CRC are lacking. The aim of this molecular pathological epidemiology study was therefore to evalua
Popular Abstract in Swedish I gruppen huvudhalscancer ingår tumörer i övre luftvägar och svalg. Riskfaktorer för huvudhalscancer är rökning och alkoholöverkonsumtion. Under de senaste 20-30 åren har det skett en påtaglig ökning av insjuknandet, 4-5% per år, i det som kallas orofaryngeal cancer. Orofaryngeal cancer utgår från mellansvalget; mandlar, tungbas och mjuka gommen. Ökningen sammanfaller mThe treatment for head and neck squamous cell carcinoma (HNSCC) is surgery or (chemo)radiotherapy +/- surgery. Side effects related to therapy are long lasting and adversely affects quality of life. The incidence of oropharyngeal cancer is increasing and patients commonly present an advanced tumour stage with neck metastases at the time of diagnosis. The treatment protocol previously comprised rad
Internet of Things (IoT), det vill säga fysiska objekt med inbyggd elektronik som kan kopplas upp mot internet och styras eller utbyta data över nätet, har idag blivit en självklar del i många personers vardag. Det kan vara allt från hälsoarmband och kylskåp, till glödlampor och termostater. Som förutspås har vi dock ännu inte sett det stora genombrottet för denna teknik och vad den kan komma att The Internet of Things (IoT), i.e. physical objects with embedded electronics that can be connected to the internet and be controlled or exchange data over the network, has become an integral part of many people's daily lives. IoT devices can be anything from fitness trackers and refrigerators to light bulbs and thermostats. However, as is being predicted, we have yet to see the major breakthr
Berggrunden i sydvästra Sverige består av bergarter som deformerades och metamorfoserades under den Svekonorvegiska kontinent kollisionshändelsen. Den så kallade ”Sveconorwegian Frontal Deformation Zone” norr om Vättern och Protoginzonen söder därom anses utgöra den östligaste gränsen för Svekonorvegisk omarbetning. Söder om Vättern är Protoginzonen en 20-30 km bred N-S deformationszon. FortsättniThe bedrock in the southwest of Sweden was deformed and metamorphosed during the Sveconorwegian orogeny. The Sveconorwegian Frontal Deformation Zone north of the lake Vättern and the Protogine Zone south of the lake is regarded as the eastmost boundary of Sveconorwegian reworking. South of lake Vättern the Protogine Zone is 20-30 km wide made up of a system of discrete ductile (and locally brittle
Induction machines have been used in a wide range of applications due to its robustness and its low price. These characteristics make the induction machine a suitable option for industrial and home environments especially for those applications where the required speed is constant and the load does not change drastically. As an alternative to the induction machine, the synchronous machine, particu
A particle accelerator consists of a large number of components, which among other things includes several acceleration modules, which consists of one or several cavities. A cavity is a complex and essential part in the accelerations process and is usually made of oxygen-free copper (OFC) or niobium. These two materials are special when it comes to metal cutting, it´s hard to find information abou
Avtalslicensbestämmelserna ger en nyttjare rätt att, på vissa i upphovsrättslagen angivna områden, träffa avtal om användning av upphovsrättsligt skyddade verk med en organisation som företräder ett flertal svenska upphovsmän på området. Genom avtalslicensen får användaren även rätt att nyttja verk av det slag och på de villkor som preciseras i avtalet av upphovsmän som inte är medlemmar av den avThe extended collective licenses grant a user the right to, under provisions that are stated in the Swedish Act on Copyright in Literary and Artistic works, enter agreement about exploitation of works with an organization that represent a substantial number of Swedish authors in the field concerned. Thanks to the extended collective license, the user is granted the right to use works protected by
A common technique within image analysis is image classification which describes the process of reducing the information content of an image into few user-defined classes. With the emergence of unmanned aerial vehicles (UAVs), high spatial resolution (cm-level) images can be collected. This thesis aims at testing different methods for classifying UAV images from an agricultural crop site in the so
Fildelningsteknologin revolutionerade internet i början av 1990-talet. I rask takt har fildelningsnätverken utvecklats och utbudet av olovligen tillgängliggjorda filer är större än någonsin. För vanliga internetanvändare innebär nyss nämnda gratis tillgång till film och musik vid efterfrågan. Det kan emellertid medföra stora ekonomiska förluster för rättighetshavarna till verken. Digitaliseringen File sharing technology revolutionized the Internet in the early 1990s. Different networks evolve at a rapid pace and the supply of illegally spread files are greater than ever. For common Internet users this means free, on-demand access to movies and music. However, it may cause major financial losses to the right-holders of copyrighted works, since the digitalization often times means losing con
Ett av Sveriges sexton miljömål är att bevara den biologiska mångfalden, alltså den mångfald av växt- och djurarter som lever i vårt land. Ett stort hot mot den biologiska mångfalden är fragmentering av de ekosystem där djuren och växterna lever. Vad innebär då fragmentering av ett ekosystem? Enkelt uttryckt kan man se fragmentering som att dela upp ett sammanhängande ekosystem i mindre utspridda The “Eastern slopes of Lake Vättern” is an area situated in the municipality of Jönköping in southern Sweden. The area has a high level of biodiversity of which much is bound to mixed broad-leaved deciduous trees and forests and contains species that are unique for this area in Sweden. The area is a candidate to become a biosphere reserve under the Unesco Man and Biosphere program. One ambition in
Problem Statement: The project started with a request from IKEA to contribute more to the environment. The task for this project, issued by IKEA, was to create a concept for a free-standing indoor storage unit for recyclable waste. The unit should hold at least seven different types of waste: cardboard, plastic, paper, metal, glass, deposit waste and some smaller hazardous waste, such as batteries
Sealings are an important part in the industrial robot. One important property of the seal is to keep all particles and fluids from the outside, away from the important components inside the robot. Another important property is to keep the oil and grease inside the robot, and prevent leakage. The seal also prevent leakage inside the industrial robot and reduces the risks of sensitive components to
Anställningsförhållandet grundas på ett personligt förhållande och präglas av ett starkt behov av förtroende. I bestående anställningsavtal skall arbetstagaren i stort sett sätta arbetsgivarens intresse framför sitt eget. Vilken skyldighet har emellertid arbetstagare att iaktta arbetsgivarens intresse vid ingående av anställningsavtalet? Syftet med denna uppsats har varit att utreda i vilken utstrWhen entering into a contract it is important to maintain a certain grade of honesty and loyalty. Not only is it wrong to deceive a party in order to reach a beneficial agreement, it is in certain cases also contrary to good faith and fair dealing to leave a mistaken party in error. The law therefore imposes a duty of disclosure that requires a party to reveal all matters known, in its entirety, t
The European Position Paper on Rhinosinusitis and Nasal Polyps 2020 is the update of similar evidence based position papers published in 2005 and 2007 and 2012. The core objective of the EPOS2020 guideline is to provide revised, up-to-date and clear evidence-based recommendations and integrated care pathways in ARS and CRS. EPOS2020 provides an update on the literature published and studies undert
Tetra Pak Packaging Material AB (TPPM) is the division within the Tetra Pak concern that produces the packaging material that later on will be used for liquid products. There are 63 TPPM plants in the world, and the factory in Lund is one of the largest with its 325 employees. It is also the TPPM factory that manufactures the most varied set of packages. There are nine producing machines, divi
Due to the globalization with free labour transfer, migrant workers are unavoidably the most targeted group for human trafficking business. Trafficking in persons is a global issue because of its engagement with the international organized crime. Apart from that, as the Protocol on Trafficking in Persons has been in force since 2003, States have turned their attention to the issue and many of them
