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Anti-neutrophil cytoplasmic antibodies (ANCAs) have a pathogenic role in ANCA-associated vasculitis. The origin of ANCAs and anti-glomerular basement membrane (GBM) antibodies, however, is unknown. In this study, we determined whether natural autoantibodies against myeloperoxidase (MPO), proteinase 3 (PR3), and GBM were present in each of 10 healthy Chinese and Swedish individuals, negative for al
För att nå Sveriges transportpolitiska mål är krävs det att fler väljer cykeln som huvudsakligt färdmedel. Genom att prioritera cyklisters trafiksäkerhet och framkomlighet ökar attraktiviteten vilket gör att fler väljer att cykla. I denna studie har tre korsningar i Malmö analyserats med avseende på trafiksäkerhet och framkomlighet där syftet var att undersöka hur trafiksäkerhet och framkomlighet In order to achieve Sweden's transport policy goals, it is required that more people choose the bicycle as their main mode of transport. By prioritizing cyclists' traffic safety and level of service, attractiveness increases, which means that more people choose to cycle. In this study, three intersections in Malmö have been analyzed with regard to traffic safety and level of service, where
Popular science summary Are drugs only drugs for human being? An experiment to see if some of the anthropogenic pharmaceuticals are toxic contaminants for the aquatic environment. All kinds of pharmaceuticals have been using widely and the amount has been increased significantly during the last few decades. Concerns about the occurrence of pharmaceuticals releasing into different matrixes of th
Potatoes Solanum tuberosum, L are among the most consumed crop type by millions of people around the world. It has high amount of starch content and it is known to be a good source of potassium, vitamin B6, vitamin C and fiber. There are more than 4000 varieties of potatoes. Salome, Ditta and Asterix cultivars are among well-known potatoes in the Swedish market. In recent years the consumption of
Groundwater resources are facing a high pressure due to drought and overexploitation. The main aim of this research is to apply rotation forest (RTF) with decision trees as base classifiers and an improved ensemble methodology based on evidential belief function and tree-based models (EBFTM) for preparing groundwater potential maps (GPM). The performance of these new models is then compared with t
Merparten studier som har undersökt hur nattjour påverkar prestation, hälsa och säkerhet, har genomförts i USA där det är vanligt med mycket långa arbetsveckor och arbetspass. Aktuell studie avsåg undersöka effekter av nattjour beträffande kognitiv funktion, riskutsatthet och belastning, under förhållanden representativa för svensk sjukvårdsorganisation. I studien deltog 30 läkare i södra Sverige,Most studies examining how on call duty nighttime affects performance, health and safety, were conducted in the United States where long working weeks and shifts are common. The current study examined the effects of on call duty nighttime on physician´s performance and strain under conditions representative for Swedish healthcare organization. The study enrolled 30 physicians from southern Sweden,
Sammanfattning Instansordningsprincipen är en förvaltningsrättslig princip som huvudsakligen medför att parterna i ett förvaltningsmål är förhindrade att tillföra nytt processmaterial i högre instanser. Principen är, emellertid, inte uttryckligen lagstadgad i Förvaltningsprocesslagen (1971:291), FPL. Istället är det upp till förvaltningsdomstolarna att tolka de uttalande som finns i förarbetena tiSummary The principle of the court hierachy is a principle within administrative law whose intention is to prevent the parties to add new case material in the higher instances. The principle, however, is not explicitly stated in the Administrative Court Procedure Act (1971: 291), FPL. Instead, the administrative courts are given the task to interpret various statements contained in the legislative
Objective: To investigate the feasibility of active heart sparing (AHS) planning in patients with locally advanced and centrally located NSCLC receiving standard definitive radiotherapy (RT), while maintaining or improving appropriate lung, esophagus, and spinal cord constraints and planning target volume (PTV) coverage intent. Methods and materials: A total of 27 patients with stage IIIA/B NSCLC
Objectives: To assess the existence of international, scientifically validated methods for manual surgical skills training and assessment. The aim was to create a descriptive chronological summary of the existing evidence and conclusions in the included articles. Methods: PubMed and Scopus were searched twice for reviews published between 1997 and October 2023 and between 1997 and January 2024. Th
Several organic cations, such as guanidino compounds and polyamines, have been found to accumulate in plasma of patients with kidney failure due to inadequate renal clearance. Here, we studied the interaction of cationic uremic toxins with renal organic cation transport in a conditionally immortalized human proximal tubule epithelial cell line (ciPTEC). Transporter activity was measured and valida
More than 50 irregular satellites revolve around Jupiter and more than 30 around Saturn. There, at least three collisional families were identified. Among these, the Himalia family of prograde irregular moons at Jupiter is characterised by a velocity dispersion of several hundred m/s, inconsistent with a collisional origin (Nesvorný et al., 2003). Here we investigate whether the dispersion could s
We examined the relationships between amyloid-β PET and concurrent and longitudinal cognitive performance in 107 cognitively normal individuals with subjective cognitive decline (age: 64 ± 8 years, 44% female, Mini-Mental State Examination score 29 ± 1). All underwent 90-minute dynamic [
Bifidobacterium longum endo-α-N-acetylgalactosaminidase (GH101), EngBF, is highly specific toward the mucin Core 1 glycan, Galβ1-3GalNAc. Apart from the side chains involved in the retaining mechanism of EngBF, Asp-682 is important for the activity. In the crystal structures of both EngBF and EngSP (from Streptococcus pneumoniae), we identified a conserved water molecule in proximity to Asp-682 an
A search is presented for the production of a single top quark via left-handed flavour-changing neutral-current (FCNC) interactions of a top quark, a gluon and an up or charm quark. Two production processes are considered: u+ g→ t and c+ g→ t. The analysis is based on proton–proton collision data taken at a centre-of-mass energy of 13 TeV with the ATLAS detector at the LHC. The data set correspond
Background: Treatment of newly diagnosed acute myeloid leukaemia (AML) is based on combination chemotherapy with cytarabine (ara-C) and anthracyclines. Five-year overall survival is below 30%, which has partly been attributed to cytarabine resistance. Preclinical data suggest that the addition of hydroxyurea potentiates cytarabine efficacy by increasing ara-C triphosphate (ara-CTP) levels through
Middle Eastern immigrants constitute a growing proportion of the European population and compared to native Swedes are more insulin resistant, which can contribute to atherosclerosis. Quantitative first pass perfusion (qFPP) using cardiovascular magnetic resonance (CMR) can detect early signs of cardiovascular disease (CVD). The aim was to study if myocardial perfusion differs between healthy male
Background: There are no evidence-based recommendations on the optimal time point to initiate non-vitamin K antagonist oral anticoagulants (NOACs) after acute ischemic stroke in patients with atrial fibrillation. We aimed to investigate the efficacy and safety of early versus delayed initiation of NOAC in these patients. Methods: TIMING (Timing of Oral Anticoagulant Therapy in Acute Ischemic Strok
Molecular signatures to guide decisions for adjuvant chemotherapy are recommended in early ER-positive, HER2-negative breast cancer. The objective of this study was to assess what impact gene-expression-based risk testing has had following its recommendation by Swedish national guidelines. Postmenopausal women with ER-positive, HER2-negative and node negative breast cancer at intermediate clinical
Purpose: The purpose of the study was to describe the design and implantation of a branched stent-graft during endovascular aortic repair incorporating double-cuff bidirectional inner branch. Technique: A new double-cuff bidirectional antegrade and retrograde inner branched stent-graft with large diamond-shaped fenestration was designed for incorporation of a splenic artery. The inner cuffs of the
Objectives: To develop EULAR recommendations for screening and prophylaxis of chronic and opportunistic infections in patients with autoimmune inflammatory rheumatic diseases (AIIRD). Methods: An international Task Force (TF) (22 members/15 countries) formulated recommendations, supported by systematic literature review findings. Level of evidence and grade of recommendation were assigned for each
