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Anti-neutrophil cytoplasmic antibodies (ANCAs) have a pathogenic role in ANCA-associated vasculitis. The origin of ANCAs and anti-glomerular basement membrane (GBM) antibodies, however, is unknown. In this study, we determined whether natural autoantibodies against myeloperoxidase (MPO), proteinase 3 (PR3), and GBM were present in each of 10 healthy Chinese and Swedish individuals, negative for al

Biotic communities in Northeast Greenland have an insular character as a consequence of the complex geomorphologic nature of the ice-free land and its interdigitation with glacial ice and the sea. Post Pleistocene movements of most plants and animals into the region have generally followed East and North Greenland coastal routes, and the majority of the plants have North American affinities. Clima

Fiducial cross-sections for [Formula: see text] production with one or two additional b-jets are reported, using an integrated luminosity of 20.3 fb[Formula: see text] of proton-proton collisions at a centre-of-mass energy of 8 TeV at the Large Hadron Collider, collected with the ATLAS detector. The cross-section times branching ratio for [Formula: see text] events with at least one additional b-j

Popular Abstract in Swedish En välfungerande andning med utbyte av syrgas och koldioxid mellan kroppen och omgivningen är en förutsättning för liv. För att detta gasutbyte ska fungera krävs bl. a. att ventilationen, dvs. in- och utflödet av luft i lungorna, står i balans med blodflödet genom lungorna. I lungorna tar blodet emot syrgas som behövs för att cellerna i kroppen ska fungera och samtidigtRespiration relies, among other things, on the balance between regional ventilation and perfusion in the lungs. There are many cardiopulmonary diseases, such as pulmonary embolism (PE), chronic obstructive pulmonary disease (COPD) and left heart failure (LHF), which can affect respiration negatively. The diagnosis of PE, COPD and LHF follows separate diagnostic pathways. However, the symptoms that

Background: There is controversy regarding the influence of ketamine and its enantiomers on cerebral haemodynamics at increased intracranial pressure (ICP). This study was designed to compare cerebrovascular responses, with particular respect to ICP, to bolus injections of racemic, S(+)- and R(-)-ketamine in an experimental model of intracranial hypertension. Methods: Nine pigs were anaesthetised

Housing rats in an enriched environment improves functional outcome after ischemic stroke, this may reflect neuronal plasticity in brain regions outside the lesion. Which components of the enriched environment that are of greatest importance for recovery after brain ischemia is uncertain. We have previously found that enriched environment and social interaction alone both improve functional recove

In this study, we assessed the performance of discharge simulations by coupling the runoff from seven Dynamic Global Vegetation Models (DGVMs; LPJ, ORCHIDEE, Sheffield-DGVM, TRIFFID, LPJ-GUESS, CLM4CN, and OCN) to one river routing model for 16 large river basins. The results show that the seasonal cycle of river discharge is generally modeled well in the low and middle latitudes but not in the hi

No consensus treatment regime exists beyond surgery for malignant peripheral nerve sheath tumours (MPNST), and the purpose of the present study was to find new approaches to stratify patients with good and poor prognosis and to better guide therapeutic intervention for this aggressive soft tissue cancer. From a total of 67 MPNSTs from Scandinavian patients with and without neurofibromatosis type 1

OBJECTIVE: This study aims to analyze the diagnostic workup in patients referred for endovascular mesenteric revascularization for symptomatic mesenteric atherosclerotic disease. MATERIAL AND METHODS: Fifty-five patients were identified between 2006 and 2011. Median follow-up time was 24 months. RESULTS: Median age was 71 years, 67 % were women. Forty patients had acute on chronic mesenteric ische

Objective The objective of this article is to determine if maternal obesity is associated with an increased risk of Down syndrome in the offspring and whether the risk estimates for trisomy 21 based on combined screening is affected by maternal body mass index (BMI). Methods Study group I consisted of a nationwide cohort of 1 568 604 women giving birth; outcome was infants born with Down syndrome

Background: Apolipoprotein J (ApoJ) is a component of plasma high-density lipoproteins. Previous studies have shown progressive recovery of ApoJ sialic acid content with increased duration of alcohol abstinence. Therefore, the sialic acid index of plasma apolipoprotein J (SIJ) seems to be a promising alcohol biomarker. Phosphatidylethanol (PEth) is a direct ethanol metabolite and has recently attr

Objective: We studied the independent and joint effects of the genes encoding alpha-synuclein (SNCA) and microtubule-associated protein tau (MAPT) in Parkinson disease (PD) as part of a large meta-analysis of individual data from case-control studies participating in the Genetic Epidemiology of Parkinson's Disease (GEO-PD) consortium. Methods: Participants of Caucasian ancestry were genotyped for

Popular Abstract in Swedish Intag av födoämnesantigen resulterar normalt i induktion av oral tolerans, men klinisk och immunologisk betydelse av kortvarig neonatal exponering för komjölksproteiner är inte klarlagt. Syftet med detta arbete var att studera prospektivt effekten av olika uppfödningsregimen under de tre första levnadsdagarna. Påverkan på makromolekylär absorption, antikropps produktionThe aim of this work was to study prospectively the effects of different feeding regimens during the first three days of life. A group of 129 infants were randomly assigned at birth to one of three feeding regimens: human milk (HM), cow's milk formula (CMF), or a casein hydrolysate formula (CHF). The formula-fed infants received no human milk until the fourth day of life, after which all infants w

Popular Abstract in Swedish Multikonjugerad Adaptiv Optik för Astronomiska Teleskop 1. Atmosfärisk turbulens Allt sedan man på 1600-talet började bruka optiska instrument inom astronomin, för att understödja det mänskliga ögat då man beskådade stjärnhimlen, har astronomer strävat efter att bygga allt större och bättre teleskop för att kunna se längre ut i rymden och skönja allt ljussvagare objekt.This work analyses several aspects of multi-conjugate adaptive optics (MCAO) for astronomy. The research ranges from fundamental and technical studies for present-day MCAO projects, to feasibility studies of high-order MCAO instruments for the extremely large telescopes (ELTs) of the future. The first part is an introductory exposition on atmospheric turbulence, adaptive optics (AO) and MCAO, esta

We have investigated the possibility of using the 2.45 GHz ISM band for communication between binaural hearing aids. The preliminary investigations were done by FDTD simulations on a modified SAM phantom head, where we have included a simple model of the ear canal. Two different types of hearing aid placements have been investigated: in the outer ear and in the ear canal. Antennas which have been

On the decision of the Swedish government, the Swedish National Road Administration (SNRA) has started a large-scale trial with Intelligent Speed Adaptation (ISA) in urban areas. One of the four test sites is the city of Lund. At the Department of Technology and Society, Lund University, research about ISA has been carried out since 1986 and the first field study was carried out in 1993. The ongoi

Introduction: The aim of this study was to evaluate the frequencies of nonsurgical retreatment, root-end surgery, extraction, and further restoration of root-filled teeth in Sweden in 2009 during a follow-up period of 5 years and to compare the outcomes in teeth restored with direct or indirect restorations. Methods: Data from the Swedish Social Insurance Agency were analyzed, and the frequencies

The purpose of this study was to develop a computer-based method for automatic detection and localization of coronary artery disease (CAD) in myocardial bull's-eye scintigrams. Methods: A population of 135 patients who had undergone both myocardial 99mTc-sestamibi rest-stress scintigraphy and coronary angiography within 3 mo was studied. Different image data reduction methods, including pixel aver

Diabetic foot ulcer is a serious complication in patients with diabetes. In most outcome studies of this condition, there is a combination of various types of ulcer and ulcer locations. Plantar ulcers are usually localized to the forefoot, and constitute a quarter of all diabetic foot ulcers. There are a limited number of studies regarding development of new ulcers following healing of a plantar f

Bladder denervation and bladder outlet obstruction are urological conditions that cause bladder growth. Transcriptomic surveys in outlet obstruction have identified differentially expressed genes, but similar studies following denervation have not been done. This was addressed using a rat model in which the pelvic ganglia were cryo-ablated followed by bladder microarray analyses. At 10 days follow