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The VDR is a prime candidate gene for osteoporosis. Here, we studied three common VDR haplotypes in relation to bone phenotypes in 5014 participants of the global MrOS Study. We also studied the relative expression of the haplotypes in human bone cells. One haplotype was associated with increased fracture risk and differently expressed in primary human bone cells. Introduction: Vitamin D plays an
This study investigates the mechanisms of (de)coding modality, focusing on the interpretation of utterances containing the modals must, may, måste, and kan. The main research question posed in this study is what enables the interlocutors to interpret modal expressions so that communicative goals are achieved. To answer this general question, Coates's (1983) study on modal contexts is initially rep
The fire technical properties of products are determining factors for the initiation and growth of fires. Measurement of fire technical properties and the understanding of how they relate to real hazards are therefore important for fire safety. This work deals with the fire technical properties of building products, their tendency to ignite and release heat in different fire scenarios. Building p
OBJECTIVE: To assess the effect of the FTO genotype on weight loss after dietary, physical activity, or drug based interventions in randomised controlled trials.DESIGN: Systematic review and random effects meta-analysis of individual participant data from randomised controlled trials.DATA SOURCES: Ovid Medline, Scopus, Embase, and Cochrane from inception to November 2015.ELIGIBILITY CRITERIA FO
Sexhandel förekommer i alla kulturer och samhällen. Trots det har detta område visat sig vara nästintill omöjligt att på ett oproblematiskt vis integrera i länders lagstiftning. En konvergent lagstiftning mellan olika områden är grundläggande för att ett lands rättssystem ska fungera. Sexhandeln är ett politiskt, moraliskt och ideologiskt ämne vilket medför komplikationer när lagstiftningsarbete kSex work occurs in all cultures and societies. Nevertheless, this area has proved almost impossible to integrate into a countries’ legislation in an unproblematic way. Convergent legislation between different areas is fundamental for the functioning of a country’s legal system. The sex trade is a political, moral and ideological subject, which entails complications when legislative work on the sub
The introduction of L-DOPA pharmacotherapy revolutionized the treatment of Parkinson’s disease close to fifty years ago. Before the discovery of dopamine as a neurotransmitter and its involvement in the disease, these patients had very little aid from medication and were bound to a life without movement. The dopamine neurons in the midbrain are a key player in the circuitry that is responsible for
WUI-NITY is a computer modelling program for wildfire evacuation simulations. This thesis examines the applicability of WUI-NITY to locations in Sweden. The program was tested at example locations representing the Swedish landscape. The objective of this work was both to examine the application of the model, but also to produce a process by which the model might be applied – highlighting challenge
I vårdnad, boende och umgängesmål ska domstolen ta hänsyn till barnets vilja, som ett led i bedömningen av barnets bästa. Bedömningen försvåras dock ibland av att barn uttrycker sig på ett sätt som egentligen inte representerar deras verkliga vilja. Vad de uttrycker är istället ett resultat av påverkan från en förälder. Att barn i viss mån påverkas av sina föräldrar när de separerar är oundvikligtIn court cases concerning custody, residence and the child’s visitation rights to a parent, an assessment of what lies in the best interest of the child is made. According to the Parental Code, the court must consider the will of the child in order to make a proper assessment. However, the assessment is complicated by the fact that, sometimes, what children express is inconsistent with their actua
As a social worker you often meet children that are exposed to harmful environments in one way or another. Children who grow up in these circumstances could easily be forgotten, there-fore it is vital that these children are brought to attention. In these situations it´s necessary to find which positiv measures would be benefitial for these children. The internet is an expan-sive resource due to t
Genome-wide association studies (GWAS) have identified more than 50,000 SNP-trait associations. Most of these SNPs or genetic variants map to noncoding regions, known as or gene desserts. This makes it challenging to describe the mechanism by which the variant confers susceptibility to the trait. Increasingly, there is an interest in characterization and interpretation of the effect of non-coding
In a digital age where travellers are increasingly looking for the cheapest, fastest or most sustainable way to travel, comparing different modes of transport efficiently becomes a challenge. The internet offers a wide range of websites and travel providers, fragmenting information and forcing travellers to navigate inefficiently between different platforms and websites. Multimodal Digital Mobili
Introduction: Soft tissue knee injury is a well-established and potent risk factor for development of knee osteoarthritis. However, there is a paucity of epidemiological data from the general population. Our aim was to estimate the annual person-level incidence for a wide spectrum of clinically diagnosed soft tissue knee injuries, and their distribution by age, sex, and season. Methods: In Sweden,
The proprietor of a copyright protected work has an economical right to make the work available to the public. The most significant form of making a work available in today’s information society is the right of communicating the work to the public. This is specifically regulated in article 3.1 in the Infosoc Directive and was implemented in 2 § URL in 2005. Especially this regulation pertains to t
I-131 radionuclide therapy studies have not shown a strong relationship between tumor absorbed dose and response, possibly due to inaccuracies in activity quantification and dose estimation. The goal of this work was to establish the accuracy of I-131 activity quantification and absorbed dose estimation when patient-specific, 3-dimensional (3D) methods are used for SPECT reconstruction and for abs
Our study aims to investigate the relationships of the major lineages within the moth family Geometridae, with a focus on the poorly studied Oenochrominae- Desmobathrinae complex, and to translate some of the results into a coherent subfamilial and tribal level classification for the family. We analyzed a molecular dataset of 1,206 Geometroidea terminal taxa from all biogeographical regions compri
BackgroundAssessment and treatment of the acutely ill patient have improved by introducing systematic assessment and accelerated protocols for specific patient groups. Triage systems are widely used, but few studies have investigated the ability of the triage systems in predicting outcome in the unselected acute population. The aim of this study was to quantify the association between the main com
Purpose: The quantitative accuracy of Nuclear Medicine images, acquired for both planar and SPECT studies, is influenced by the isotope-collimator combination as well as image corrections incorporated in the iterative reconstruction process. These factors can be investigated and optimised using Monte Carlo simulations. This study aimed to evaluate SPECT quantification accuracy for 123I with both t
Background Influenza and other respiratory viruses promote Streptococcus pneumoniae proliferation in the upper respiratory tract. We sought to investigate for what we believe is the first time, the effect of intranasal live attenuated influenza vaccine (LAIV) on nasopharyngeal S pneumoniae density in a low-income to middle-income country population with high pneumococcal carriage rates. Methods I
Although a number of different medium access control (MAC) schemes are adopted for wireless multi-hop networks, time division multiple access (TDMA) approaches based on a periodic frame of time slots are the most common when very high efficiency is needed in terms of use of radio and energy resources. Efficient resource usage is typically based on parallel compatible transmissions from multiple no
