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An association between the intake of heterocyclic amines (HAs) and the development of cancer has been observed in some epidemiological studies, while in other studies no such correlation has been found. HAs are mutagenic/carcinogenic compounds formed at low levels via the Maillard reaction and a free radical mechanism during cooking of animal tissue. The addition of pure antioxidants or foods cont
Popular Abstract in Swedish Värmebehandling (termoterapi) av tumör baseras på kunskap om den celldödande effekten av värme. Den har begränsats av svårigheten att kontrollera temperaturutbredningen så att en selektiv och tillräcklig effekt erhålls, och detta gäller särskilt djupt belägna tumörer. Interstitiell laser termoterapi (ILT) med Nd:YAG laser är en ny behandlingsform, som ger de tekniska föInterstitial laser thermotherapy (ILT) is a method well suited for selective local destruction of malignant tumours. In the present work, a laser thermotherapy system based on feedback temperature control of energy delivery (through computerised feedback system) was developed. Temperature control was excellent in experiments without carbonization and with preserved light penetration, whereas tempe
We analyze cross correlations between price fluctuations of different stocks using methods of random matrix theory (RMT). Using two large databases, we calculate cross-correlation matrices C of returns constructed from (i) 30-min returns of 1000 US stocks for the 2-yr period 1994-1995, (ii) 30-min returns of 881 US stocks for the 2-yr period 1996-1997, and (iii) 1-day returns of 422 US stocks for
Cross-linking of polyvinylalcohol (PVA) by boronate-containing copolymer of N,N-dimethylacrylamide (DMAA, 1) was studied and compared to cross-linking of PVA by borate buffers in weakly alkaline solutions. The copolymer of M-w = 19,000 g mor(-1) containing 9 mol% N-acryloyl-m-aminophenylboronic acid (NAAPBA, 2) was prepared by free radical polymerization of the monomers, exhibiting copolymerizatio
Allelopathy, the release of extracellular compounds that inhibit the growth of other microorganisms, may be one factor contributing to the formation and/or maintenance of cyanobacterial blooms. We investigated the allelopathic effects of three cyanobacterial species (Nodularia spumigena, Aphanizomenon flos-aquae and Anabaena lemmermannii) that frequently form mass-occurrences in the Baltic Sea. We
The aim of this thesis was to study annually laminated (varved) Holocene lake sediment in Sweden, their formation and their potential as chronological and palaeoecological archives. Five lakes with continuous Holocene varved lake sediment sequences in northern (Västerbotten) and west central Sweden (Värmland) were investigated. Three of these sequences were discovered during this study, which iden
Syftet med denna studie är att ur ett sociologiskt perspektiv undersöka hur det är att bo i Barcelona och arbeta i ett internationellt callcenter som ung europeisk medborgare. Vad är det som motiverar individer att migrera och arbeta i Barcelona? Hur upplever de förutsättningar i arbetet, social gemenskap och hur uppfattar de sin tillhörighet? Dessa frågeställningar sätts sedan i en bredare kontexThe aim of this study is from a sociological perspective understand how it is to live in Barcelona while working in an international call centre as a young European citizen. What motivates these individuals to migrate to Barcelona? What is their perspective of work, social community and notion of belonging? These questions are later to be examined together with theories of migration, modernization
Background: Increased expression of cyclooxygenase-2 (COX-2) is common in non-small cell lung cancer (NSCLC) and has been associated with poor prognosis. Experimental and clinical phase II trials have indicated that the addition of the COX-2 inhibitor celecoxib to palliative chemotherapy might increase survival time in patients with advanced NSCLC. Methods: We performed a double-blind, placebo-con
The articular cartilage of synovial joints ensures friction-free mobility and attenuates mechanical impact on the joint during movement. These functions are mediated by the complex network of extracellular molecules characteristic for articular cartilage. Zonal differences in the extracellular matrix (ECM) are well recognized. However, knowledge about the precise molecular composition in the diffe
Abstract Background: Velopharyngeal dysfunction (VPD) can have various causes and may be a significant disability for the affected patient. Treatment options include surgery and speech therapy, but the success rates are often inconsistent. Methods: In this study, self-assessment questionnaires were sent out to 222 Swedish patients with VPD. The questionnaire included questions about satisfaction w
We report on the performance of the third-order Douglas–Kroll ab initio model potential (DK3-AIMP) method-based electron-correlated spin–orbit calculations. Our treatment assumes that the problem can be separated into a spin–free correlation treatment and a spin–orbit calculation. The correlation effects were calculated using the multistate complete active space second-order perturbation method, a
Of increasing interest in the field of protein modelling and simulation is the effects of crowding. In a living cell, large molecules can take up 30% of the cell plasma volume, and affects the folding and dynamics of proteins. Computer simulations have so far focused mainly on simple spherical crowders, but recent simulations with protein crowders have shown effects beyond what can be replicated u
Recent years molecular imprinting has received considerable attention as an excellent and simple approach to recognize small molecules and bioactive substances. The aim of this study is to prepare the bilirubin-imprinted supermacroporous cryogels which can be used for the adsorption of bilirubin from human plasma. N-methacryloyl(L)-tyrosinemethylester (MAT) was chosen as the preorganization monome
The climate impact of new cars in Sweden 2009 has been evaluated by the Swedish Transport Administration. Their report takes into account reduction factors to attribute the positive impact of renewable fuels on CO2 emissions. The Swedish Transport Administration recommends the public to buy cars that can run on biofuels. Besides acknowledging prevailing uncertainties for many of the input paramete
OBJECTIVE: Describe the clinical course and predictors of change in self-reported outcomes and objectively assessed physical function over time in middle-aged subjects at high risk of, or with knee osteoarthritis (OA). METHODS: We examined 259 subjects (mean age 52.6 [SD 10.4]) at mean 18 and 25 years after previous meniscectomy and 50 population-based age- and sex-matched reference subjects with
The new clusters [Ru-3(CO)(9)(mu-dppf){P(C4H3E)(3)}] (1, E = O; 2, E = S) have been prepared from the Me3NO-induced decarbonylation of [Ru-3(CO)(10)(mu-dppf)] in the presence of PFu(3) (E = O) and PTh3 (E = S), respectively. Upon thermolysis in benzene, the major products are the cyclometalated clusters [(mu-H) Ru-3(CO)(7)(mu-dppf){mu(3)-(C4H3E)(2)P(C4H2E)}] (3, E - O; 4, E - S). This thermolytic
Beta-blockers (bisoprolol, metoprolol succinate, carvedilol, and to some extent nebivolol), given on top of angiotensin-converting enzyme (ACE) inhibitors, improve survival and reduce morbidity in symptomatic stable chronic heart failure (CHF). Early beta-blockade may help to improve survival and especially prevent sudden death, but the usual practice of starting the ACE inhibitor first may lead t
A simpler version of a shock-testing machine was developed and built. This allows engineers at Verisure to test prototypes and early versions of new products before the product is certified. An independent company shock tests the product as part of the process to certify it as an approved home alarm security product. During the shock test, the product is subjected to a high acceleration during a s
Just leave but feel free to come back: on the social services outreach work with people who renounce the need for help In this study I have been interested in the meetings that take place between outreach workers in social services and people who involuntarily are approached. More specifically, I have focused on the meetings with adult people who renounce the need for help from the outreach worke
Deciphering where genes are expressed within the complex architecture of cells and tissues requires advanced spatial transcriptomics techniques. This study focuses on Multiplexed Error-Robust Fluorescence In Situ Hybridization (MERFISH), a technique for spatial transcriptomic. The MERFISH experiment involves probes binding to specific RNA-targeted sequences within fixed cells and tissues. I develo
