Filtyp
Orbit integration for three different assumed Intermediate-mass Black Hole (IMBH, defined as black holes with mass MBH in the range 100Mo < MBH 104Mo) populations in the Milky Way for 10 Gyr has been performed. Upon collision with molecular clouds in the galactic disc, the relative velocity between both objects has been measured and the luminosity resulting from the gas accretion process onto the
A plant’s rain coat Imagine yourself taking a walk on a cloudy day. Suddenly, the sky opens and the rain is pouring down making you totally soaked. Now imagine that you predicted that it would start to rain so you put on a rain coat. When the rain starts to fall, you won’t get wet since the rain drops will strike against the rain coat and get drained. In the same manner, the wax on plants is prot
Under det senaste seklet har det svenska samhället utvecklats från att ha varit ett industrisamhälle till att bli ett kunskapssamhälle. Denna utveckling har inneburit att s.k. kunskapsföretag har kommit att få en alltmer central roll i samhället. Kunskapsföretag kännetecknas av att de främst bedriver kunskapsproduktion och inte materiell produktion. Det är de anställdas kunskap som utgör kunskapsfDuring the last century, the Swedish society has developed from being an industrial towards becoming a knowledge-based society. As a consequence, so-called knowledge management-companies have come to occupy a central role in society. Knowledge management-companies ́ primary production is knowledge and not matter. Since the employees possess the knowledge, they are the most valuable resources of th
Background: The Andean indigenous philosophy known as Buen Vivir or Sumak Kawsay, loosely translated into Good Living or Well Living, is rarely studied within the field of public health. The studied philosophy has been institutionalized in Bolivian and Ecuadorian constitutions, why it sets the agenda for health in the Andean region. The ongoing progression of the health definition, combined with gThis study has looked upon how a philosophy called Sumak Kawsay or Buen Vivir explains what health means. The studied philosophy has its origins in the Andes in Latin America. The reason why this study was done came from the writers wish to understand what the philosophy meant, and how it could be used within public health-work. The writer thought that it is important to include different explanat
In Sweden as well as in The Netherlands energy policy is increasingly aiming at extending the use of renewable sources. In accordance with the targets of the European Union, both countries have formulated national targets for the year 2020. For wind energy these targets are 30.0 TWh of electricity in Sweden and a total installed capacity of 10.0 GW in The Netherlands. Wind is an inflexible, variab
Jura novit curia anses innebära att parterna inte kan binda domstolen vid vilken rättsregel som är tillämplig. Och inte heller hur denna rättsregel ska tolkas och tillämpas. Denna princip vållar emellertid vissa problem. Syftet med denna uppsats har varit att utreda om principen om jura novit curias omfattning enligt gällande rätt är välavvägd samt att annars ge förslag på bättre lösningar. PrinciIura novit curia implies that the parties cannot, with binding effect for the court, choose which law should be applied. Nor can they choose how the law should be interpreted or applied. The purpose of this paper was to investigate whether the extent of the principle of iura novit curia in Swedish law is balanced. If not so, the aim is to provide suggestions for a better solution. Iura novit curia
Popular science summary: NADase – a way to avoid immune system activation? Streptococcus pyogenes (S. pyogenes) are bacteria that cause many different kinds of diseases in humans, for example strep throat, scarlet fever and necrotizing fasciitis, the ”flesh-eating disease”. An infection with this type of bacteria can also lead to heart and kidney damage, thought to be caused by our immune system
This dissertation deals with memory, recognition and solidarity in the Nowa Huta district of Kraków, Poland. Nowa Huta was founded as an independent, socialist model town in 1949, together with the large Lenin Steel Plant, and was incorporated into Kraków in 1951. In the 1980s the steel plant and district became one of the main centers of the oppositional Solidarity movement in Poland. Situated be
Metalloenzymes are proteins that contain one or more metal ions bound to protein. They constitute about one-third of all enzymes known so far and they often perform hard chemical reactions involving small substrates, like H2 and N2. In our research, we focus on those metal ions that are located in the active sites and perform redox reactions, i.e. involving electron transfer. Why enzymes? As we kMetalloenzymes catalyse a wide variety of reactions in nature. In the thesis, I have studied the reaction mechanism of three metalloenzymes, viz. [NiFe] hydrogenase (H2ase), dimethyl sulfoxide reductase (DMSOR) and formate dehydrogenase (FDH), by theoretical methods, namely quantum mechanics (QM), combined quantum mechanical and molecular mechanics (QM/MM), as well as QM/MM thermodynamic cycle per
Background: Quality of life (QOL) has become an important complementary endpoint in cancer clinical studies alongside more traditional assessments (eg, tumour response, progression-free survival, overall survival). Niraparib maintenance treatment has been shown to significantly improve progression-free survival in patients with recurrent ovarian cancer. We aimed to assess whether the benefits of e
Chronic obstructive pulmonary disease (COPD) is a progressive life-threatening disease that is significantly increasing in prevalence and is predicted to become the third leading cause of death worldwide by 2030. At present, there are no true curative treatments that can stop the progression of the disease, and new therapeutic strategies are desperately needed. Advances in cell-based therapies proTo date, bone marrow-derived mesenchymal stromal cells (MSCs) have been considered the golden standard among MSC cell-based therapies. However, the harvesting of bone marrow is a highly invasive procedure and the number of MSCs isolated is low, and it declines with increasing age. MSCs with immune-regulatory and regenerative properties can be isolated from many different tissues; however, bone mar
Chronic obstructive pulmonary disease (COPD) is a progressive life-threatening disease that is significantly increasing in prevalence and is predicted to become the third leading cause of death worldwide by 2030. At present, there are no true curative treatments that can stop the progression of the disease, and new therapeutic strategies are desperately needed. Advances in cell-based therapies proChronic obstructive pulmonary disease (COPD) is a progressive life-threatening disease that is significantly increasing in prevalence and is predicted to become the third leading cause of death worldwide by 2030. At present, there are no true curative treatments that can stop the progression of the disease, and new therapeutic strategies are desperately needed. Advances in cell-based therapies pro
Background: The management of cervical cancer patients with intraoperative detection of lymph node involvement remains controversial. Since all these patients are referred for (chemo)radiation after the surgery, the key decision is whether radical hysterectomy should be completed as originally planned, taking into account an additional morbidity associated with extensive surgical dissection prior
The association between a randomly pyrene labeled PAA polymer (PAAMePy55) and a PEO-PPO-PEO triblock copolymer (P123) in aqueous solutions of different NaCl concentrations and pHs has been studied by means of dynamic light scattering (DLS) and steady-state fluorescence spectroscopy at 40 °C. At acidic pH values, in the low P123/PAAMePy55 molar ratio regime (i.e., at low P123 concentrations), the r
Popular Abstract in Swedish Detta är en prospektiv longitudinell multicenterstudie som har haft som mål att utvärdera livskvaliteten (HRQL) hos patienter med cancer i huvudhalsregionen, vid diagnos, efter ett och fem år i relateration till tumörlokal, stadium, subsite, behand-ling, kön och ålder. Den första delen av studien, som varade i ett år, bestod av 357 patienter (medelålder 63 år; 72% män)The aim of this prospective longitudinal multicenter study was to evaluate the health-related quality of life (HRQL) in patients with head and neck cancer at diagnosis, after one and five years in relation to tumour location, stage, sub site, treatment modality, gender and age. The first part of the study, lasting for one year, consisted of 357 patients (mean age 63 years; 72% males) that were in
The aim of this study was to evaluate the contribution of a low calcium diet to the cortical and trabecular osteoporosis seen in ovariectomized rats after 7 weeks on a low calcium diet and to investigate the effects of the bisphosphonate clodronate on this development of osteoporosis. Thirty-six mature, female Wistar rats were randomized into four groups: Ovx-B (bisphosphonate) and Ovx-C (control)
1. The structure of chondroitin/dermatan and heparan-sulphate chains from various proteoglycan populations derived from cultured human skin fibroblasts have been examined. Confluent cell cultures were biosynthetically labelled with [3H]-glucosamine and 35SO4(2-), and proteoglycans were purified according to buoyant density, size and charge density [Schmidtchen, A., Carlstedt, I., Malmstrom, A. &am
OBJECTIVE: To follow the effect of a 4-month pelvic floor exercise (PFE) program in women with naïve urinary incontinence with vaginal electromyography (EMG), pressure and palpation and also to compare the initial findings with symptom-free women of the same age.METHODS: The pelvic floor function expressed with vaginal EMG, pressure and palpation was measured before, during and after 4 months of P
Popular Abstract in Swedish Vävnadskallikrein (VK) är ett äggvitespjälkande protein som dels kan aktivera vävnadsnedbrytande enzymer som kollagenas och gelatinas och dels spjälkar kininogen till kininer (bradykinin och kallidin). Via bindning till speciella kininreceptorer (B2 receptorer) som finns överallt i kroppen, styr kininerna olika processer i de flesta av kroppens organ och vävnader såsom Tissue kallikrein releases pharmacollogically highly active kinins from kininogen. Many other enzymes may also release kinins. The aim of the study was to clarify the pathophysiological role of tissue kallikrein in acute pancreatitis. Two sensitive and specific radioimmunoassays for porcine and human tissue kallikrein were developed. A large release of tissue kallikrein from the pancreatic gland
