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This article proposes nonparametric inference procedures for analyzing microarray gene expression data that are reliable, robust, and simple to implement. They are conceptually transparent and require no special-purpose software. The analysis begins by normalizing gene expression data in a unique way. The resulting adjusted observations consist of gene-treatment interaction terms ( representing di
When an excess of human cystatin C or chicken cystatin was mixed with papain, an enzyme-inhibitor complex was formed immediately. The residual free cystatin was then progressively converted to a form with different electrophoretic mobility and chromatographic properties. The modified cystatins were isolated and sequenced, showing that there had been cleavage of a single peptide bond in each molecu
1. Mechanical transients in fibre bundles of skinned smooth muscle of guinea-pig taenia coli at 21-22 degrees C were investigated by recording tension responses to length changes of up to 9%, complete within 0.3 ms. 2. The length-force relationship, recorded continuously during rapid stretch of a Ca(2+)-activated contracted muscle, was linear up to at least 2.5 times the isometric force, correspon
Introduction. The European Multiple System Atrophy-Study Group (EMSA-SG) is an academic network comprising 23 centers across Europe and Israel that has constituted itself already in January 1999. This international forum of established experts under the guidance of the University Hospital of Innsbruck as coordinating center is supported by the 5th framework program of the European Union since Marc
Dealing with water diffuse pollution is a major problem for watershed managers. This problem raises many complicated questions, which are important to answer in order to reach water environment protection goals. This study suggested some possible answers for the country of Lithuania. Among them were the identification of critical source areas, the identification of sensitive areas and the applicat
Title: Synergi, a digital reporting tool for working environment. Authors: Sebastian Larsson & Joel Ståhl Supervisor: Radhlinah Aulin, Senior lecturer at the Department of Building and Environmental Technology, Division of Construction Management, Lund University. Examinator: Anne Landin, Professor at the Department of Building and Environmental Technology, Division of Construction Management,
Det blir allt vanligare att människor flyttar mellan länder för att bo, studera, arbeta eller leva som pensionär. Till en persons hemvist knyts allt fler rättigheter och skyldigheter i samhället vilket skapar ett ökat behov för individen och staten att kunna fastställa var en person har sin hemvist. Idag finns ingen enhetlig tolkning av hemvistbegreppet. En persons hemvist kan därför variera mellaToday it is common for people to move across borders to live, study, work or retire. A person’s residence is linked to an increasing number of rights and obligations in society, which creates an increased need for both the individual and the state to determine where a person has its residence in different situations. Today there is no uniform interpretation of the concept. Where a person is consid
Purpose: To optimize a method and develop an algorithm to quantify Fatty Acid Composition (FAC) in bone marrow adipose tissue. By using different reconstruction models, compare different MRI systems (3 T and 7 T) to find the optimal field strength and reconstruction model for FAC quantification. Also, to develop a reference phantom with bone marrow-like characteristics. Method: Multi-echo GRE (Gr
Syftet med denna uppsats är att undersöka hur avvägningen mellan effektivitet och rättssäkerhet i förarbetena till skattetillägget kommit att påverka hur dagens skattetillägg fungerar i praktiken vid Skatteverkets kontrollverksamhet avseende tjänsteavdrag. Detta redogörs för genom att dagens regelverk och de förarbeten som legat till grund för skattetillägget analyseras i förhållande till effektivThe purpose of this essay is to investigate how the trade-off between efficiency and rule of law during the legislation processes for the tax surcharge has come to affect how today's tax surcharge works in practice regarding the Swedish Tax Agency's monitoring of tax deductions for work-related expenses made by natural persons. This essay will examine this through analyzing today's reg
Sweden has traditionally pursued a restrictive policy on alcohol. One of the fundamental and outstanding features of this policy is the monopolization of the retail sales of alcoholic beverages. Spirits, wine and beer with an alcohol content of more than 3.5 per cent by volume may only be sold by the State-owned Systembolaget AB. The products available in Systembolaget's shops are selected and
MAX-lab is a national synchrotron radiation facility in Lund. Nowadays, the MAX project consist of three facilities (three storage rings). A new storage ring is needed to improve material science, such as nanotechnology. MAX IV, also in Lund, will be 100 times more efficient than already existing synchrotron radiation facilities. The storage ring is controlled by a large number of magnets that are
During the last half-century there has been an increase in the volume and complexity of international business. Nowadays it is easy to carry through different types of transactions between Member States of the EU. One example can be an establishment, to avoid or at least reduce taxes, particulary by taking advantage of tax incentives offered by many countries to attract geographically-mobile capit
Monte Carlo-simuleringar har fått en ökad betydelse som forskningsverktyg inom nuklearmedicinsk bildgivning eftersom man på ett mycket kontrollerat sätt kan studera nästan vad man vill. I denna studie har datorsimuleringar av ett PET-system gjorts med ett program som heter GATE. PET (Positron Emission Tomography) är en nuklearmedicinsk bildgivningsteknik som används mer och mer inom sjukvården sIntroduction: Monte Carlo simulation is a powerful tool in research in the field of nuclear medicine imaging and there is a wide area of applications. The purpose of this work was (1) to understand the basics of the Monte Carlo simulation software Geant4 Application for Tomographic Emission (GATE); (2) to create a model of Philips Gemini TF PET/CT system; (3) to run a number of simulations to comp
Background: Bococizumab is a humanized monoclonal antibody that inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9) and reduces levels of low-density lipoprotein (LDL) cholesterol. We sought to evaluate the efficacy of bococizumab in patients at high cardiovascular risk. Methods: In two parallel, multinational trials with different entry criteria for LDL cholesterol levels, we randomly
Objective: To facilitate a greater likelihood of favorable response to new disease-modifying therapies, recruitment of patients at an earlier stage of their disease into clinical trials may be an attractive strategy. Hence, there is a need to develop widely accepted classification criteria for early-stage knee osteoarthritis (OA). We have proposed a set of classification criteria for early-stage k
Background: Totally implantable venous access devices (TIVADs) have improved the quality of life for seriously ill and cancer patients. These devices represent a convenient option when long-term venous access is indicated. The Subclavian and Internal Jugular Veins are the vessels of choice for catheterization [1]. However, if it is not possible to catheterize them, an alternative vein should be so
The increase in extreme weather confirms that in order to slow down climate change, unnecessary travel must be reduced. Consequently, tourism industry has an obligation to start launching more environmentally friendly travel concepts and replace destructive charter tourism until sufficient emission-free vehicles that run on electricity become norm. Developing Staycation into innovative and attract
INTRODUCTION: We studied whether adding percent free prostate-specific antigen (%fPSA) to total PSA improves prediction of clinically significant prostate cancer (csPCa) and fatal PCa.METHODS: 6727 men within the intervention arm of the Prostate, Lung, Colorectal and Ovarian Trial had baseline %fPSA. Of this cohort, 475 had csPCa and 98 had fatal PCa. Cumulative incidence and Cox analyses were con
Background: Cognitive impairment is common following out-of-hospital cardiac arrest (OHCA), but the nature of the impairment is poorly understood. Our objective was to describe cognitive impairment in OHCA survivors, with the hypothesis that OHCA survivors would perform significantly worse on neuropsychological tests of cognition than controls with acute myocardial infarction (MI). Another aim was
Background and Objectives: There is considerable heterogeneity in the association between increasing β-amyloid (Aβ) pathology and early cognitive dysfunction in preclinical Alzheimer disease (AD). At this stage, some individuals show no signs of cognitive dysfunction, while others show clear signs of decline. The factors explaining this heterogeneity are particularly important for understanding pr
