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MHC genes are extraordinarily polymorphic in most taxa. Host-pathogen coevolution driven by negative frequency-dependent selection (NFDS) is one of the main hypotheses for the maintenance of such immunogenetic variation. Here, we test a critical but rarely tested assumption of this hypothesis—that MHC alleles affect resistance/susceptibility to a pathogen in a strain-specific way, that is, there i
Aim: Risk of treatment-related life-threatening toxicity is high in childhood acute myeloid leukaemia (AML), and access to intensive care units (ICU) is crucial. We explored the ICU admission rate and outcome after intensive care in childhood AML in Sweden. Methods: Patients diagnosed between 2008 and 2016 were identified from the Swedish Childhood Cancer Registry (SCCR), a national quality regist
Lactose plays a significant role in daily lives as a constituent of various food and pharmaceutical products. Yet, lactose intolerance conditions demand low-lactose and lactose-free products in the market. These increasing nutritional claims and labels on food products entail simple and reliable methods of analysis that can be used for meeting quality standards, nutritional claims and legal requir
The 2030 Agenda of the United Nations comprises 17 Sustainable Development Goals (SDGs) and 169 sub-targets which serve as a global reference point for the transition to sustainability. The agenda acknowledges that different issues such as poverty, hunger, health, education, gender equality, environmental degradation, among others, are intertwined and can therefore only be addressed together. Impl
In this article, a dataset of age-depth modelling data, sedimentation rates and dust mass accumulation rates (MAR) from four loess-palaeosol sequences from the Carpathian Basin is presented. The dataset is related to the article “Detailed luminescence dating of dust mass accumulation rates over the last two glacial-interglacial cycles from the Irig loess-palaeosol sequence, Carpathian Basin”, publ
Functional size, or function points, is a language-independent measure of software size. It is used as an estimator of development effort and software code size, in particular in the domain of information systems, while in real-time systems it is not so widely spread. In this paper, functional size measurements are empirically evaluated by applying them to a recently completed project. Two establi
In the present study, we investigate the combined interaction of mesoporous silica (SiO2) and photocatalytic titanium dioxide (TiO2) nanoparticles with lipid membranes, using neutron reflectometry (NR), cryo-transmission electron microscopy (cryo-TEM), fluorescence oxidation assays, dynamic light scattering (DLS), and ζ-potential measurements. Based on DLS, TiO2 nanoparticles were found to display
Background: Survivors of childhood acute lymphoblastic leukemia (ALL) may be at increased long-term risk of hospitalization for somatic diseases. However, large population-based cohort studies with risk estimates for survivors successfully cured without experiencing a relapse or requiring hematopoietic stem cell transplantation (HSCT) are lacking. Methods: Danish and Swedish patients diagnosed wit
This thesis attempts to implement a library in pure Python for building real-time Brain-Computer Interface (BCI) systems. The library does this by employing nodes containing data transformation methods—filtering, classification, data acquisition, and more. These nodes are linked together to create pipelines of nodes in which data flows. Due to the asynchronous nature of the data flow the library w
High costs, time delays, inefficiency and complicated border procedures when engaging in cross-border trade hinders competitiveness and economic development in many developing countries, such as Uganda. To try to reduce these obstacles and challenges, Uganda has implemented One-stop border posts, intending to make international trade cheaper, quicker, and simpler. This paper investigates the effic
The project aims to learn about Chinese young people's choices and attitudes towards cooking and solve their problems in cooking. The solution is presented in the form of a product --- a multifunctional electrothermal cooking appliance. The traditional Chinese saying "Food is god for the people" shows the importance of diet in Chinese life. But today, more and more Chinese young peo
Climate change impacts global agricultural systems through changes in average temperature, precipitation quantity and timing, and extreme weather events. Climate change adaptation (CCA) for agricultural systems will be based on changes to farms’ day-to-day operations and long-range planning, governmental policies and regulations, and broad changes in supply chains. The purpose of this thesis is to
Bakgrund: Depression samt ångest tillhör de stora folksjukdomarna som drabbar många i arbetsför ålder. Diagnoserna står för cirka 90 % av sjukskrivningar i Sverige som är orsakade av psykisk ohälsa. Det finns dock kunskapsluckor gällande effektiva interventioner som syftar till arbetsåtergång för individer med psykisk ohälsa. Syfte: Syftet var att ur ett arbetsterapeutiskt perspektiv kartlägga in
Upphovsrätten präglas av flera svåra gränsdragningar varav denna uppsats fördjupar sig inom en av dessa. Svårigheten som behandlas i detta sammanhang består av problematiken att avgöra var gränsen går mellan ett skyddat verk och en oskyddad idé. Vissa aspekter inom området är tydliga, i form av att enbart en idé inte kan åtnjuta upphovsrättsligt skydd medan en färdig produkt har möjlighet till skyThe Copyright law is filled with difficulties regarding boundaries of with this thesis deepens itself within one of these. The difficulty in this context consists of the problem of determining where the boundaries, in which a work can be qualified for copyright protection, lies between a protected work and an unprotected idea. Since certain aspects of the field are clear, in the form of that an id
Many of our freshwater resources are contaminated with pollutants such as heavy metals and organophosphates, and therefore the demand for reliable and efficient methods for detection and remediation of such pollutants is increasing. One widely used method for remediation of water is through the use of engineered communities of microbes that have the ability to degrade or make the contaminating com
In the summer of 2014, a violent conflagration erupted in the isolated Palestinian enclave of Gaza. Whilst the fighting was between Hamas and Israel, Palestinian civilians paid the price. The stark disparity in deaths triggered a debate in the West about Israeli tactics, and the media was accused of ‘bias’ by both Israelis and Palestinians. What this controversy reveals is that the argument is abo
Cell culturing is most commonly performed in conventional 96-well plates where cells are grown in a monolayer, on two-dimensional (2D) surfaces. However, a tumor grows in three dimensions (3D) in the human body and exhibits complex features that cannot be translated onto a 2D system. Likewise, an anti-cancer drug that has been pre-clinically tested in a 2D system is likely to fail clinical trials.
Purpose: With increasing obesity rates and the change of beauty ideals within society, the plus-size fashion market currently enjoys a massive upturn and many established fashion retailers realise the opportunities within this ever more important segment. However, the integration of plus-size brands can be challenging as being plus-size is still connected to a stigma. Therefore, it is surprising t
