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Background: Pathological aggregation of tar DNA-binding protein 43 (TDP-43) in the brain is the primary cause of many cases of frontotemporal lobar degeneration (FTLD), amyotrophic lateral sclerosis (ALS) and limbic-predominant age-related TDP-43 encephalopathy (LATE). It is therefore imperative to establish empirical staging systems to characterize and distinguish stereotypical patterns and commo
Traditionally, automatic control techniques arose due to need for automation in mechanical systems. These techniques rely on robust mathematical modelling of physical systems with the goal to drive their behaviour to desired set-points. Decades of research have successfully automated, optimized, and ensured safety of a wide variety of mechanical systems. Recent advancement in digital technology ha
Therapeutic antibodies are the fastest growing class of drugs but suffer from a crowded target-space where many antibodies, against a few targets, are developed in parallel. The aim of this thesis is to find methods to enable discovery of novel antibody-target combinations and thereby increase the target-space. A strategy to achieve this is to use phage display antibody libraries and selection on
The Oak of Mambre presents an inner world of sound exploration, whose strands are woven through ancient cultures and traditions. Mambre is a birthplace, itself, literal and ideal. Compressions and rarefactions tell two stories; of Abram and Mambre, of survival and an heir.The Oak of Mambre begins where the reality and existence of a tone becomes manifest. Here we are looking at the sub-particulate
Popular Abstract in Swedish Med föreliggande avhandling vill jag belysa att Chrétien de Troyes Graalsaga, till skilnad från vad de åtskilliga kritiker har påstått, inte bygger på traditionella ridderliga värden, men väl avslöjar en problematisk ideologi. Denna ideologi prövas med hjälp av V. Jouves metod, som beskrivs i hans Poétique des valeurs. Graalsagans värden analyseras ur ett dubbelt perspThis dissertation aims at showing that Chrétien de Troyes' Conte du Graal does not, as often affirmed, uphold traditional chivalrous values, but discloses a problematic ideology, mostly as a result of multiple interactions at the textual level. In order to examine ideology, Le Conte du Graal is analysed in the light of the poetics elaborated by Vincent Jouve in his Poétique des valeurs (2001). Fol
Context. Recent spectroscopic surveys have begun to explore the Galactic disk system on the basis of large data samples, with spatial distributions sampling regions well outside the solar neighborhood. In this way, they provide valuable information for testing spatial and temporal variations of disk structure kinematics and chemical evolution. Aims. The main purposes of this study are to demonstra
Digitala Självbetjäningslösningar – Den utmanande tjänsten En studie av bankers övergång till digitala självbetjäningslösningar Josefine Andreasson Charlotte Mikander 2014-09-11 Handledare: Kandidatuppsats Catharina Norén 2014 Abstract Why: Bachelor thesis, Service Management, Lunds University, Campus Helsingborg, Spring 2014 Authors: Josefine Andreasson & Charlotte Mikander Title: Di
Detta arbete behandlar och utreder begreppet provocerad uppsägning och dess användning i svensk rätt. Arbetet har begränsats till att endast avhandla den svenska rätten eftersom det inte finns EU-rättsliga bestämmelser som motsvarar det som finns i den svenska anställningsskyddslagen. Eftersom det endast finns mycket begränsad doktrin på området så har begreppet utretts med hjälp av rättsfallstudiThis work discusses and investigates the concept provoked dismissal and its use in Swedish law. The essay has been limited to only discuss the Swedish law since there are no EU rules corresponding to those found in the Swedish Employment Protection Act. Since there is only very limited doctrine on the subject, the concept has been investigated using case studies. The legal cases are taken from the
En följd av den nya lagen (2014:307) om straff för penningtvättsbrott har varit att ett flertal myndigheter, i diverse rapporter, riktat kritik mot att det råder brist på rättspraxis avseende straffvärdebedömningar i mål om penningtvättsbrott. Utöver dessa myndighetspublikationer är litteraturen om den straffrättsliga regleringen av penningtvättsbrott knapphändig. Det har därför varit av intresse The novel Act regarding penalties for money laundering offences (2014:307) has been criticized by a number of authorities. This, due to the fact that judicial precedent about penal assessment in cases of money laundering offence is scarce. Furthermore, there is a lack of evidence in the literature concerning the new legislation. Therefore, it has been interesting as a part of my essay to study how
Following the development of new materials and the continuous technical progress made in the construction and energy industries, district heating as a concept finds itself on the brink of a generational shift. One of the pioneering projects leading the way is the creation of Brunnshög, an modern and sustainable district under construction in the north-eastern end of the city of Lund, Sweden. The a
I samband med lantmäteriförrättningar där ersättningsbeloppet behöver framtas med hjälp av de värderingsmedel som Lantmäteriet eller utsedd värderingsman har att tillgå är det ytterst viktigt att ingångsparametrarna är korrekta. Då fastighetsregleringar där vinstfördelning blir aktuellt och där genomsnittsvärdeprincipen aktualiseras är det råtomtmarksvärdet som eftersöks. I värderingsutlåtandet reDuring land surveying operations, the amount of compensation needs to be calculated using the valuation means taken by the land surveyor or appointed appraiser. For this reason, it is important that input parameters are correct. As profit distribution is a pressing concern in relation to real estate regulations, raw land value is sought after. In this case, the responsible land surveyor reports fo
I takt med den tekniska utvecklingen behandlas personuppgifter i allt större utsträckning och mer gränsöverskridande. Behandling och överföring av personuppgifter är förenat med en risk för att individens integritetsskydd åsidosätts. EU har en stark dataskyddslagstiftning och värnar om skydd av EU-medborgares personuppgifter. USA har inte en lika stark dataskyddslagstiftning. Samtidigt är USA enWith the fast development in information technology, personal data is increasingly being processed and interchanged cross-border. Processing and transfer of personal data is associated with a risk that the individual's privacy protection is disregarded. The EU has strong data protection legislations and a strong protection of the personal data of EU citizens. The U.S. does not have as strong
I den statliga utredningen, Ett snabbare bostadsbyggande, undersöktes hur utnyttjandet av byggrätter kunde effektiviseras. Underlaget var dock tämligen begränsat, vilket skapade idén till den här rapporten. I vilken utsträckning förekommer outnyttjade byggrätter och varför utnyttjas de isåfall inte? Syftet med denna rapport är att utreda om det finns outnyttjade byggrätter med ändamål flerbostadsIn the public report, Ett snabbare bostadsbyggande, a research was made to find out how the utilization of undeveloped building rights could be made more efficient. However, the material on which the research was based was found insufficient, which created the idea for this report. To what extent do undeveloped building rights occur and what are the reasons? The purpose of this report is to exami
Title: Shipment Consolidation Policy Project. A case study at the Integrated Logistics Product Area at the Case Company. Authors: Carl Tornerhjelm, Tom Wachtmeister. Supervisor: Peter Berling, the Division of Production Management. Background: Larger corporations that distribute products and goods globally face both internal and external demands from stakeholders. High service levels call for freq
The aim of this thesis is to study the self-images built on the social media Instagram by the re-elected Mayor Ko Wen-je and the second place Ting Shou-chung in 2018 Taipei mayoral election. Through conducting a qualitative content analysis as the research method and applying Goffman’s dramaturgy theory as the theoretical framework to analyse every Ko and Ting’s Instagram posting in the duration o
Det har blivit vardag för allmänheten att dagligen läsa rubriker om sprängningar, skjutningar, mord och narkotikabrott. Dessa brott har ökat de senaste åren, så pass mycket att många inte längre höjer på ögonbrynen när man läser om det i medierna. Osäkerheten och otryggheten i samhället har ökat i takt med att den organiserade brottsligheten har ökat. De senaste åren har den organiserade brottsliIt has become commonplace for the general public in Sweden to read daily news reports about explosions, shootings, homicides, and narcotics related crimes. These types of crimes have increased during the last years, to such an extent that many people do not feel safe. With rising crime rates, there is an increased sense of insecurity and uncertainty. The criminals have adopted new technologies, a
Governments around the world have begun to adopt measures in support of electric vehicles. The supply push policies have been traditionally studied leaving the demand side innovation policy without much investigation. Therefore, policy makers lack institutional knowledge and policy experience. The demand side innovation policies have always been part of the public policy decisions but not part of
Popular Abstract in Swedish Resenärsinformation utformad för att uppfylla behov och förväntningar hos enskilda resenärer är viktigt för att förbättra resandet i kollektivtrafiken bland äldre personer och personer med funktionsnedsättningar. Det övergripande syftet med den här avhandlingen är att bidra till kunskapen om behov och användning av resenärsinformation bland äldre personer och personer mTraveller information designed to fulfil needs and expectations of individual travellers is a key factor in improving access for older people and people with disabilities to public transport. The overall aim of this thesis is to contribute to the knowledge of user and provider perspectives on the provision of traveller information for older people and people with disabilities in public transport w
How can a small fire at a subcontractor in the USA lead to a multimillion dollar loss at a Swedish telephone company, and how can a single machine breakdown lead to a complete production stop at a production company? With today logistics and production trends, where terms such as Lean Production, Six Sigma, 5S, and World Class Manufacturing are used every day, production companies are introducing
This essay deals with a certain part of the EC directive on liability for defective products called the state-of-the-art defense. The defense protects the manufacturers from liability from damages caused by a defect that could not be foreseen given the technical and scientific knowledge available at the time the product was developed. Most member states have, since the directive saw its light in t
