Filtyp
Myeloproliferative neoplasms (MPNs) are blood cancers that are characterized by the excessive production of mature myeloid cells and arise from the acquisition of somatic driver mutations in haematopoietic stem cells (HSCs). Epidemiological studies indicate a substantial heritable component of MPNs that is among the highest known for cancers1. However, only a limited number of genetic risk loci ha
Non-smooth convex optimization problems occur in all fields of engineering. A common approach to solving this class of problems is proximal algorithms, or splitting methods. These first-order optimization algorithms are often simple, well suited to solve large-scale problems and have a low computational cost per iteration. Essentially, they encode the solution to an optimization problem as a fixe
Significance: In recent years, a number of studies have shown altered oxygen partial pressure at a tissue level in metabolic disorders, and some researchers have considered oxygen to be a (macro) nutrient. Oxygen availability may be compromised in obesity and several other metabolism-related pathological conditions, including sleep apnea-hypopnea syndrome, the metabolic syndrome (which is a set of
Aim: Health and nutrition in early childhood are essential for survival, growth and adult life outcomes. As such, a number of global and national interventions have been pursued to improve early childhood health and nutrition. However, child malnutrition is pervasive and endemic across the sub Saharan Africa. This paper therefore assesses the nature and trends of socioeconomic inequalities in chil
Cysteine proteinases are important not only in the intracellular catabolism of peptides and proteins1 and in the processing of prohormones and proenzymes2,3, but also in the penetration of normal human tissue by malignant cells4 and possibly microorganisms5, including viruses. Cystatin C is a human cysteine proteinase inhibitor present in extracellular fluids6. We have synthesized peptide derivati
The Lund Botanical Society 2007-03-23 decided to launch a project with the following aims: 1) to map the frequency and distribution of all bryophytes in the province of Skåne, southernmost Sweden, thereby making way for future studies of changes in the flora, 2) to find and document as many sites as possible for nationally and regionally rare or endangered bryophytes and initiate conservation acti
Most of the world's poor live in developing markets and face unmet needs in core areas such as education, health, energy, sanitation and financial services. This offers businesses a vast opportunity for growth as these economies emerge from low-income to middle-income status. Social businesses in particular address a social need while generating profits typically reinvested into the business itsel
While the number of stars in the Galactic bulge with detailed chemical abundance measurements is increasing rapidly, the inner Galactic bulge (|b| < 2°) remains poorly studied, due to heavy interstellar absorption and photometric crowding. We have carried out a high-resolution IR spectroscopic study of 72 M giants in the inner bulge using the CRIRES (ESO/VLT) facility. Our spectra cover the wavele
Objectives: Constant infusion lumbar infusion test (LIT) is an important way to find which patients, of those with signs and symptoms corresponding to normal pressure hydrocephalus (NPH) who will improve from shunt operation. LIT is a stress test on the ability for cerebrospinal fluid re-absorbtion. The aim of this study is to show how the information from LIT can be improved by quantitative analy
Exoplanet interior modelling usually makes the assumption that the elemental abundances of a planet are identical to those of its host star. Host stellar abundances are good proxies of planetary abundances, but only for refractory elements. This is particularly true for terrestrial planets, as evidenced by the relative differences in bulk chemical composition between the Sun and the Earth and othe
Environmental disasters, and especially floods, are among today's biggest sustainability challenges. The number and intensity of floods are increasing, challenging current governance approaches. Governments worldwide are looking to diversify their flood risk management and adaptation strategies, among others, by increasing resident involvement in flood risk governance. Such involvement of individu
We present a model for the concurrent formation of globular clusters (GCs) and supermassive stars (SMSs, ≳103M⊙) to address the origin of the HeCNONaMgAl abundance anomalies in GCs. GCs form in converging gas flows and accumulate low-angular momentum gas, which accretes on to protostars. This leads to an adiabatic contraction of the cluster and an increase of the stellar collision rate. A SMS can
Over the last two decades, several large terror attacks have led to increased discussion of the use of different surveillance technologies. The use of novel technologies for pre-emptive security and surveillance has been discussed and criticized academically, but few studies have addressed the public. Studies that target the public tend to assume an oversimplified trade-off between privacy and sec
The intensification of agricultural practices throughout the twentieth century has had large detrimental effects on biodiversity and these are likely to increase as the human population rises, with consequent pressure on land. To offset these negative impacts, agri-environment schemes have been widely implemented, offering financial incentives for land-owners to create or maintain favourable habit
Context. The Gaia satellite will measure highly accurate absolute parallaxes of hundreds of millions of stars by comparing the parallactic displacements in the two fields of view of the optical instrument. The requirements on the stability of the "basic angle" between the two fields are correspondingly strict, and possible variations (on the microarcsec level) are therefore monitored by an on-boar
Previous research has shown that the relationship between the news and parliament is complex and highly variable. Studies have found that in many countries, parliament has minimal influence on the news. However, in the UK, a reciprocal influence between parliament and the news was found, with the media having a stronger effect. This thesis investigates how the news and parliament affect each other
Purpose: The purpose of this thesis is to analyze the fossilization in language acquisition of Italian of two Swedish learners. I intend to use the Processability Theory and the Theory of gradual construction of italian verbs of the Pavia project. I also intend to investigate the sources of linguistic input of the learners . Methodology: I have recorded two learners as they speak and based on th
I denna uppsats undersöker jag problemet med bolagskapning och till viss del hur detta reflekterar det underliggande problemet med Bolagsverkets system för registrering av bolagsuppgifter med syfte att förstå problemet och identifiera lösningsmöjligheter inom gällande rätt samt nytillkomna lagändringar. För att förstå problemet med bolagskapning lyfter jag fram tidningsartiklar och statistiska undIn this essay, I examine the issue with the hijacking of corporations and, in part, how this reflects the underlying problem with the system for registration of corporation details of the Swedish Companies Registration Office, with the objective of understanding the issue and identifying possible solutions within the existing legislation as well as recently implemented changes of the legislation.
