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During development, hematopoietic stem cells (HSCs) undergo a rapid expansion in the fetal liver (FL) before settling in the adult bone marrow. We recently reported that proliferating adult HSCs are vulnerable to ER stress caused by accumulation of mis-folded proteins. Here, we find that FL-HSCs, despite an increased protein synthesis rate and a requirement for protein folding, do not upregulate E
Objective: Reconstruction with deep inferior epigastric perforator flap (DIEP) is considered to be the first choice for autologous breast reconstruction. The primary aims of this retrospective study were to find out if differences in smoking habits and BMI are useful predictors for postoperative complications in DIEP surgery. Methods: Three hundred and one patients were included. Data regarding sm
Previous studies have found that elites differ from the general population not only in terms of their demographic and social composition but also with respect to policy preferences and attitudes. When it comes to civil society organisations, the issue of representation and representativeness of top-level leadership is of particular relevance, since a small number of individuals are expected to act
BACKGROUND: De novo oligometastatic prostate cancer (omPCa) on prostate-specific membrane antigen (PSMA) positron emission tomography (PET) is a new disease entity and its optimal management remains unknown. OBJECTIVE: To analyze the outcomes of patients treated with cytoreductive radical prostatectomy (cRP) for omPCa on PSMA-PET. DESIGN, SETTING, AND PARTICIPANTS: Overall, 116 patients treated wi
Den 1 januari 2019 trädde nya skatteregler för den svenska företagssektorn i kraft. De nya reglerna innebär bl.a. att det infördes en generell begränsning av ränteavdrag i bolagssektorn. Syftet med reglerna var att förhindra erodering av den svenska skattebasen. Implementeringen ifrågasattes i en rad remissinstanser då området dels blivit svåröverskådligt genom den turordningsregel som lagts tillOn the 1st of January 2019, new tax regulations within the Swedish corporate sector was set in motion. The regulations constitute a general restriction of interest deductions within a company. The main purpose of the new regulations was to prevent erosion of the Swedish tax base. The implementation was questioned in a number of bodies considering proposed legislation, as the legislative area has
This thesis is a collaborative project between the division of Production and Materials Engineering and Trelleborg AB. The aim of the thesis is to analyse the current pre-batch polymer handling process, assess the current process from a Lean perspective, and provide a new handling process which is more effective in terms of capacity, operator time, forklift transportation and traceability. The cur
Emerging markets have shown higher average returns alongside higher volatility. This has attracted investors around the globe who see these markets as a precious alternative to developed ones, as has become clear in the aftermath of the financial crisis. Hence, we consider it logical that more emphasis be put on investigating not only stock market returns in these developing economies, but also th
Scientific summary: Amongst other affected countries, Namibia endured seasonal floods in different parts of the country namely, Karas, Kavango, Caprivi, Ohangwena, Omusati, and Oshana regions. However, the study was only conducted on the floods within the Ohangwena region. Major flooding in this region became eminent from 2007, and only rapid appraisal assessments were conducted. As a consequence,
Along with the rapid development of investment and trade in the context of economic globalisation, a number of legal issues, risks and disputes related to the essential security exception have gradually emerged in the field of international investment. Although contracting states have consciously agreed on essential security exception regulations in the international investment system, the provisi
This thesis describes the process to build an entity recognizer and disambiguator, named HERD. The goal of the system is to find mentions of entities in text and link those mentions to a unique identifier. This system is designed to be multilingual and has versions in English, French and Swedish. I use Wikipedia as a knowledge source of both names and concepts, and Wikidata, a language agnostic,
Survey response rates are declining in most developed countries, and Sweden is no exception. Declining response rates are believed to be due to recent social and tech-nological development in society. Young people are the most difficult to recruit. The increase in nonresponse is often explained by a phenomenon called “survey fatigue” – i.e. that people become overwhelmed by the number of surveys t
The motivation for the project is to investigate what happens if I add a second Earth in the Solar System and project it forward in time. I add an Earth mass planet (called Earth two) in the same orbit as the Earth on the other side of the Sun (i.e. six months ahead of the original Earth). I then investigate how the perturbation of the second Earth effects the Solar System in the short and the lon
Den territoriellt förankrade politiken har sin grund i suveränitetsprincipen som idag alltmer får stå tillbaka för de globala förändringsprocesser som har präglat vår omvärld de senaste decennierna. Judikaliseringen är en av dessa processer där allt fler politiskt viktiga frågor avgörs av domstolar och andra judiciella organ istället för av politiska instanser. När normer som demokrati och mänskliThe foundation of territorially legitimated politics lies in the principle of sovereignty. These have been forced to retreat/stand back to the global processes of change, which have been shaping the world around us during recent decades. One of these processes is judicalization where an increasing number of politically important questions are determined by courts and other judicial organs rather t
As a growing number of popular films continue to document development issues related international development, it became ever more crucial to move beyond treating these films as mere sort of entertainments and start questioning how these popular commercial films are representing the developing world as well as the messages embedded in them. Some critics have pointed out that these Hollywood-produ
Corruption has been around for centuries. Cross-border direct investments just for decades. Recent empirical research has found, that countries with rising corruption witness a decline in foreign direct investments. Poland is a paradox in this matter as both corruption and foreign investments are rising. This paper tries to find an answer to that question through examining the relationship between
Following a time period where a large number of refugees and immigrants had been received by Germany, the German minister of development proposed a new framework for Africa policy in the beginning of 2017 targeting the root causes of poverty and large migration flows. Titled Marshall Plan with Africa, the project aims to establish a new partnership between the continents, highlighting private inve
Begreppet Anthropocene har börjat användas för att betona att förhållandena på jorden styrs av mänsklig aktivitet och inte av naturliga processer, som under holocen. Antropocen är dock ännu inte helt definierat, varken tidsmässigt eller stratigrafiskt. Syftet med den här studien är därför att definiera vad som kännetecknar antropocen, utreda de stratigrafiska markörer som definierar dess början ocThe term Anthropocene has begun to be used to emphasize that conditions on Earth are governed by human activity and not by natural processes, as in the Holocene. However, the Anthropocene is not yet fully defined, neither temporally nor stratigraphically. The purpose of this study is therefore to define what characterizes the Anthropocene, investigate stratigraphic markers that define its beginnin
