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Protein kinase C (PKC) plays a prominent role in immune signaling, and the paradigms for isoform selective signaling are beginning to be elucidated. Real-time microscopy was combined with molecular and biochemical approaches to demonstrate a role for PKC-epsilon in Fcgamma receptor (FcgammaR)-dependent phagocytosis. RAW 264.7 macrophages were transfected with GFP-conjugated PKC isoforms, and GFP m
Size-selective predation has been proposed to be one important evolutionary force shaping life-history traits in guppies (Poecilia reticulata). Populations living in the presence of the ring-tailed pike cichlid (Crenicichlasaxatilis) are smaller, mature earlier, allocate more energy to offspring and get more and smaller young than guppies in localities without Crenicichla. We investigated if Creni
Curative therapies for Ewing sarcoma have been developed within cooperative groups. Consecutive clinical trials have systematically assessed the impact and timing of local therapy and the activity of cytotoxic drugs and their combinations. They have led to an increase of long-term disease-free survival to around 70% in patients with localized disease. Translational research in ES remains an area i
In this paper, an inverse source reconstruction method with great potential in radome diagnostics is presented. Defects, e.g., seams in large radomes, and lattice dislocations in frequency selective surface (FSS) radomes, are inevitable, and their electrical effects demand analysis. Here, defects in a frequency selective radome are analyzed with a method based on an integral formulation. Several f
In the 23-km-diameter Haughton impact structure, Canadian High Arctic, in sulfate-rich bedrock, widespread hydrothermal sulfide mineralization occurred in breccias formed during the impact. The sulfides exhibit extreme sulfur isotopic fractionation relative to the original sulfate, requiring microbial sulfate reduction by thermophiles throughout the crater. This evidence of widespread microbial ac
A full-scale inside out hollow fibre membrane module was operated in a pilot-scale water treatmentplant in Sweden for a period of 12 months from August 2013 to July 2014. Liquid chromatography–organic carbon detection (LC-OCD) chromatogram indicated the membranes could effectivelyremove 86% of dissolved organic carbon and 92% of humic substances from the feedwater. Routinecleaning-in-place was conA full-scale inside out hollow fibre membrane module was operated in a pilot-scale water treatment plant in Sweden for a period of 12 months from August 2013 to July 2014. Liquid chromatography– organic carbon detection (LC-OCD) chromatogram indicated the membranes could effectively remove 86% of dissolved organic carbon and 92% of humic substances from the feedwater. Routine cleaning-in-place was
Living systems integrate biochemical reactions that determine the functional state of each cell. Reactions are primarily mediated by proteins. In proteomic studies, these have been treated as independent entities, disregarding their higher-level organization into complexes that affects their activity and/or function and is thus of great interest for biological research. Here, we describe the imple
Strongly selected characters can be transferred from one lineage to another with limited genetic exchange, resulting in asymmetric introgression and a mosaic genome in the receiving population. However, systems are rarely sufficiently well studied to link the pattern of introgression to its underlying process. Male common wall lizards in western Italy exhibit exaggeration of a suite of sexually se
Gene transfer is a promising drug delivery method of advanced therapeutic entities for Parkinson's disease. One advantage over conventional therapies, such as peripheral delivery of the dopamine pre-cursor L-DOPA, is site-specific expression of proteins with regenerative, disease-modifying and potentially neuroprotective capacity. Several clinical trials have been performed to test the capacity of
Side localization of parathyroid adenomas was performed by venous sampling for intact parathyroid hormone (PTH) in 20 consecutive patients with primary hyperparathyroidism (pHPT) after induction of anesthesia. The results were thus available during surgery. Nineteen of the patients had solitary parathyroid adenoma, and one had hyperplasia. There was no complication to the procedure. A lateralizing
Seawater intrusion (SWI) is one of the most important phenomena which occurs in shorelines and islands and affects groundwater storage in the region. This study aims to investigate how far seawater has intruded in a coastal area and what is its extent variation. The results can lead to different management plans. To achieve these goals, a geoelectrical method is applied in the coastal aquifer of C
A polymer electrolyte fuel cell (PEFC) is an electrochemical device that converts chemical energy into electrical energy and heat. The energy conversion is simple; however, the multiphysics phenomena involved in the energy conversion process must be analyzed in detail. The gas diffusion layer (GDL) provides a diffusion media for reactant gases and gives mechanical support to the fuel cell. It is a
Many Gram-positive pathogenic bacteria employ ribosomal protection proteins (RPPs) to confer resistance to clinically important antibiotics. In Bacillus subtilis, the RPP VmlR confers resistance to lincomycin (Lnc) and the streptogramin A (SA) antibiotic virginiamycin M (VgM). VmlR is an ATP-binding cassette (ABC) protein of the F type, which, like other antibiotic resistance (ARE) ABCF proteins,
The stringent response is a global reprogramming of bacterial physiology that renders cells more tolerant to antibiotics and induces virulence gene expression in pathogens in response to stress. This process is driven by accumulation of the intracellular alarmone guanosine-5′-di(tri)phosphate-3′-diphosphate ((p)ppGpp), which is produced by enzymes of the RelA SpoT homologue (RSH) family. The Gram-
Energy dispersive x-ray spectroscopy in a transmission electron microscope is often the first method employed to characterize the composition of nanowires. Ideally, it should be accurate and sensitive down to fractions of an atomic percent, and quantification results are often reported as such. However, one can often get substantial errors in accuracy even though the precision is high: for nanowir
Photonic materials for high-temperature applications need to withstand temperatures usually higher than 1000 °C, whilst keeping their function. When exposed to high temperatures, such nanostructured materials are prone to detrimental morphological changes, however the structure evolution pathway of photonic materials and its correlation with the loss of material's function is not yet fully underst
Body acceleration due to heartbeat-induced reaction forces can be measured as mobile phone accelerometer (m-ACC) signals. Our aim was to test the feasibility of using m-ACC to detect changes induced by stress by ultra-short heart rate variability (USV) indices (standard deviation of normal-to-normal interval-SDNN and root mean square of successive differences-RMSSD). Sixteen healthy volunteers wer
