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Background: The main purpose for measuring urinary free sialic acid (FSA) is to diagnose sialic acid (SA) storage diseases. Elevated amounts of conjugated sialic acid (CSA) are observed in several diseases indicating the need to quantify CSA as well. A LC-MS/MS method for quantification of FSA and total sialic acid (TSA) in urine is developed and validated. Methods: FSA is analyzed directly after
Under Almedalsveckan 2026 är Lunds universitet som vanligt på plats med panelsamtal och seminarier i Visby 24-25 juni på Hästgatan 13. Dessutom medverkar många av våra forskare i andras paneler och diskussioner under hela veckan. Seminarier 24 juniSeminarier 25 juniUniversitetets medverkan i andra evenemang 22–26 juni Seminarier 24 juni Mat, mikrober och motståndskraft – bioteknikens roll för sven
https://www.lu.se/samverkan-och-innovation/popularvetenskapliga-arrangemang/almedalsveckan - 2026-06-23
ESI-LC-MS/MS method with isotope dilution and SPE based on cation-exchange was developed for determination of free and total Nε-(1-Carboxymethyl)-l-Lysine (CML) and free Nε-(1-Carboxyethyl)-l-Lysine (CEL). The use of nonafluoropentanoic acid in mobile phase was omitted, SPE recoveries of 82±3% and 91±10% (n=6) for CML and CEL respectively and, calibration curves (R(2)>0.9985) were attained. The me
Our research group on paediatric haematology is focused on bleeding- and coagulation disorders in children, in particular on haemophilia and venous thrombosis. Haemophilia A and B are hereditary, X chromosomal recessive bleeding disorders caused by deficiency or absence of coagulation factors VIII (FVIII) or IX (FIX) in the blood. The general aim of this part of the research program is to improve Our research group on paediatric haematology is focused on bleeding- and coagulation disorders in children, in particular on haemophilia and venous thrombosis. Haemophilia A and B are hereditary, X chromosomal recessive bleeding disorders caused by deficiency or absence of coagulation factors VIII (FVIII) or IX (FIX) in the blood. The general aim of this part of the research program is to improve
Seawater intrusion has been aggravated due to anthropogenic reasons, such as sea level rise and over abstraction of groundwater, which is spoiling the groundwater sustainability. This study focused on a negative hydraulic barrier using a barrier well as a countermeasure. Two lab-scale experiments and a numerical analysis with a 2-D solute transport model were conducted to examine an optimal locati
2025-12-01 Tablets under production, expected for calibration end of December. 2025-07-29 Test batch expected to arrive for calibration and quality control mid August. 2025-06-12 Our manufacturer are waiting for one tablet ingredient. 2025-01-22 We will produce a test batch with a manufacturer in Sweden. 2024-10-18 We currently have no Lycopodium tablets for sale. Our tablet manufacturer has shut
https://www.geologi.lu.se/service/pollen-tablets - 2026-06-23
Every day about 1 trillion new blood cells are formed, of which the majority are red blood cells. This depends on a small number of hematopoietic stem cells that are able to both self-renew to maintain the stem cell pool, and to mature into all types of mature blood cells. Anemia is associated with aging, chronic infections and cancer, and significantly impacts quality of life and survival. It is
Popular Abstract in English Life on earth has evolved countless forms, beautiful shapes and colors as well as astonishingly complex systems. Remarkably, all living creatures consist of cells, which themselves are build from the same basic set of molecules, most importantly nucleic acids (RNA and DNA), lipids and proteins. The latter are large macromolecules that fulfill a vast number of tasks; theThe three-dimensional structure of protein is encoded in its amino acid sequence. Modern structure prediction algorithms make it possible to predict the structure of small proteins using sequence information alone. We used the Fold-and-Dock algorithm, which is part of the Rosetta macromolecular modeling suite, for de novo structure prediction of coiled-coil proteins. Members of this protein family
Acoustic fatigue can occur in structural elements of an aircraft exposed to very high sound pressures. To deal with acoustic fatigue, mainly empirical methods have been applied and often late in the design phase. Current design guidelines have three main limitations. First, they do not say anything about the load intensities. The load levels can be determined either experimentally or numerically. Acoustic fatigue can occur in structural elements of an aircraft exposed to very high sound pressures. To deal with acoustic fatigue, mainly empirical methods have been applied and often late in the design phase. Current design guidelines have three main limitations. First, they do not say anything about the load intensities. The load levels can be determined either experimentally or numerically.
Introduction: In conventional medical linear accelerators, the flattening filter is introduced in the photon beam line to provide a uniform lateral dose profile at a specified depth in water. For some radiotherapy treatments, e.g. intensity modulated radiotherapy, a flat radiation field is not necessary and the flattening filter could be removed. Several studies have shown that removal of the filt
Uncoupling protein 2 (UCP2) is a protein, located in the inner mitochondrial membrane, which dissipates the proton gradient of this membrane and uncouples respiration from oxidative phosphorylation. We found, by in situ hybridisation, UCP2 mRNA to be located in the proliferating zone of the mucous neck cells in the fundus part of the rat stomach. We also found that UCP2 expression in fundus was si
The argument in this paper is that Hobbes’ theory of freedom in Leviathan allows for four ways of being free to act – corporal freedom by nature, freedom from obligation by nature, the freedom to disobey, and the freedom of no-rule – each corresponding to a particular absence, some of which make sense only in the civil state. Contrary to what some have claimed, this complexity does not commit Hobb
Free energy perturbations have been performed on two blue copper proteins, plastocyanin and nitrite reductase. By changing the copper coordination geometry, force constants, and charges, we have estimated the maximum energy with which the proteins may distort the copper coordination sphere. By comparing this energy with the quantum chemical energy cost for the same perturbation on the isolated cop
Primary schooling was made mandatory in Sweden in 1842. Previous literature on this well-known reform centres on the related political discussions at central level. This thesis examines how local school financing evolved in the 19th century in response to increased engagement from the central government and why it evolved the way it did. A particular focus is on the largely overlooked local level
Generation of good non-repeatable and non-predictable random number sequences is of increasing importance, both in security applications and in simulations. A novel, compact system is presented in which a secure random number is generated by sampling a chaotic system and using this bitstream as the input to a pseudo-random generator. An optional hash function can be used on the seed in order to de
Superconducting devices, based on the Cooper pairing of electrons, play an important role in existing and emergent technologies, ranging from radiation detectors1,2 to quantum computers3. Their performance is limited by spurious quasiparticle excitations formed from broken Cooper pairs4–12. Efforts to achieve ultra-low quasiparticle densities have reached time-averaged numbers of excitations on th
Free space optics is an interesting alternative for telemetry with medical implants, due to the high data bandwidths available at optical frequencies. Especially implanted brain-computer interfaces gives rise to large data sets that needs to be transmitted transcutaneous. In this paper we show that it is possible to establish such a link at near-IR wavelengths using a modulated reflector in the im
