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Although the beneficial effect on breast cancer of adjuvant tamoxifen (TAM) is well established, in the series studied by our group this effect seems to have been restricted to patients with steroid receptor (especially progesterone receptor (PgR)) positive tumors. However, as some patients with PgR-positive tumors manifested recurrence despite adjuvant TAM treatment, the question arose whether so

The elastic properties of amorphous TiNiSn, a promising half-Heusler system for flexible and wearable devices, were investigated using experimental and theoretical methods. Nanoindentation measurements performed on amorphous TiNiSn thin film grown by magnetron sputtering yielded an elastic (Young’s) modulus value of 132 GPa. To corroborate this result, density functional theory (DFT) calculations

The transition to sustainable energy is crucial for modern society, and Reverse Electrodialysis (RED) offers a promising method for harvesting energy from salinity gradients. However, large-scale deployment of RED is constrained by efficiency limitations and the high cost of ion exchange membranes. This study focuses on the development of novel asymmetric cation exchange membranes (CEMs) based on

Today there are still single family houses with direct electric heating systems, even though this is an expensive and inefficient way of heating a house. It is common to install an air-to-air heat pump that requires less electricity to produce the same amount of heat as a direct electricity heating system. These heat pumps do not produce any energy for domestic hot water since the water is heated

In the year of 1999, Sweden became the first country in the world to criminalize the act of buying sexual services. However, selling sexual services for compensation still remains legal even up to this day. Arguments about gender equality, the protection of prostitutes and the connection of prostitution to trafficking were used to support the Swedish legislation. Opponents to this argue that this

While climate models broadly agree on the changes expected to occur over the Arctic with global warming on a pan-Arctic scale (i.e. polar amplification, sea ice loss, and increased precipitation), the magnitude and patterns of these changes at regional and local scales remain uncertain. This limits the usability of climate model projections for risk assessments and their impact on human activities

Ferritin, the central iron storage protein, has attracted attention as a biomarker of severe COVID-19. Few studies have investigated regulators of iron metabolism in the context of COVID-19. The aim was to evaluate biomarkers for iron metabolism in the acute phase response to community-acquired pneumonia (CAP) caused by SARS-CoV-2 compared with CAP caused by bacteria or influenza virus in hospital

BACKGROUND: Firefighting foam-contaminated ground water, which contains high levels of perfluoroalkyl substances (PFAS), is frequently found around airports. In 2018 it was detected that employees at a municipal airport in northern Sweden had been exposed to high levels of short-chain PFAS along with legacy PFAS (i.e., PFOA, PFHxS, and PFOS) through drinking water.OBJECTIVES: In this study, we aim

A green route for the production of 6-carbon polymer building blocks 6-hydroxyhexanoic acid, adipic acid and ϵ-caprolactone from 1,6-hexanediol, a hydrogenation product of biobased 5-hydroxymethylfurfural is reported. Gluconobacter oxydans oxidized 1,6-hexanediol completely to adipic acid, and selectively at pH 6-7 to 6-hydroxyhexanoic acid, which was converted to ϵ-caprolactone by catalytic cycli

Novel approach for membrane modification to improve separation performance and antifouling stability was proposed. It involves using of 0.1–0.3 wt.% aqueous solutions of Praestol 859 (cationic polyelectrolyte based on copolymer of acrylamide and 2-acryloxyethyltrimethylammonium chloride) as coagulants upon membrane preparation via non-solvent induced phase separation. It was shown that the additio

CMKLR1 (chemoattractant-like receptor 1) is a G-protein-coupled receptor implicated in cartilage and bone development and is expressed in organs like the parathyroid gland, brain, and lung. The receptor is also expressed in dendritic cells and in macrophages where it acts as a co-receptor for entry of HIV/SIV isolates into human CD4(+) cells. Recently, a protein named "chemerin" (also known as TIG

BACKGROUND: It is increasingly acknowledged that satisfaction with sexual relations forms an important aspect of people's lives, but little is known of factors associated with this phenomenon among people with mental illness. AIM: This study aimed to investigate how demographic, social, clinical, and health-related factors were related to satisfaction with sexual relations. METHODS: Patients with

Angiogenesis and increased permeability of the blood-brain barrier have been reported to occur in animal models of Parkinson's disease and l-dopa-induced dyskinesia, but the significance of these phenomena has remained unclear. Using a validated rat model of l-dopa-induced dyskinesia, this study demonstrates that chronic treatment with l-dopa dose dependently induces the expression of vascular end

BACKGROUND: Higher operative risks after pneumonectomy for non-small cell lung cancer (NSCLC) have been reported after neoadjuvant chemotherapy or radiotherapy, or both. Patients who underwent pneumonectomy for NSCLC were evaluated for effect of neoadjuvant treatment on mortality and morbidity, especially bronchopleural fistula. METHODS: Between 1996 and 2003, 130 consecutive patients underwent pn

The development of inhibitory antibodies to factor VIII is a serious complication of haemophilia. Two haemostatic agents with different bypassing mechanisms have been used in the treatment of patients with inhibitors: activated prothrombin complex concentrate (aPCC) and recombinant factor VIIa (rFVIIa). The objective was to compare cost and outcome of aPCC and rFVIIa in the treatment of joint blee

In the present study, a simple and reliable antioxidant screening technique based on lactate dehydrogenase (LDH) oxidation by Cu2+-mediated Fenton's reaction has successfully been developed. Oxidation of LDH by hydroxyl radical consequently leads to enzymatic inactivation, while addition of antioxidants can protect and regain enzyme activity. This method demonstrated a high feasibility on detectin