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An unbalanced chromosome number (aneuploidy) is present in most malignant tumours and has been attributed to mitotic mis-segregation of chromosomes. However, recent studies have shown a relatively high rate of chromosomal mis-segregation also in non-neoplastic human cells, while the frequency of aneuploid cells remains low throughout life in most normal tissues. This implies that newly formed aneu
Congenital muscular dystrophy with laminin α2 chain-deficiency (MDC1A) is one of the most severe forms of muscular disease and is characterized by severe muscle weakness and delayed motor milestones. The genetic basis of MDC1A is well-known, yet the secondary mechanisms ultimately leading to muscle degeneration and subsequent connective tissue infiltration are not fully understood. In order to obt
Previous research suggests that time-based working memory limits of 2-3 s constrain the integration of verbal information, and that speakers tend to parse sentences into prosodic phrases that do not extend beyond this time window. The present study used Event-Related Potentials (ERPs) to investigate how time-driven implicit prosodic phrasing influences the syntactic processing of embedded clauses.
Apicidin is a potent histone deacetylase inhibitor (HDACI) that selectively binds to histone deacetylases (HDACs) class I and interferes with the deacetylation process, which results in modification of acetylation level of cellular proteins. The aim of the study was to investigate the potential time and dose dependent cytotoxicity of the test compound, Apicidin, in pancreatic cancer cells Capan-1
Portland cement clinkers from two production units were investigated in order to determine the effects of mineralisation on alite and belite; Plant 1: ordinary clinker (P1) and clinker mineralised with CaF2 + CaSO4 (P1M); Plant 2: ordinary clinker (P2) and two clinkers mineralised with CaF2 + CaSO4 (P2m, P2m'). The polymorphism of alite was studied using synchrotron X-ray powder diffraction (XRD),
Vietnam's increased integration into the global market economy entails rapid and dynamic changes that foster new ways of acting, interacting and rendering the world meaningful. This article addresses the ways in which an ongoing process of transformation in contemporary Vietnam is epitomised by the ambivalence and ambiguity with which female sexuality is imbued. Female sexuality is ideally restric
In order to model the individual electron transfer steps from the manganese cluster to the photooxidized sensitizer P680+ in Photosystem II (PS II) in green plants, the supramolecular complex 4 has been synthesized. In this complex, a ruthenium(II) tris-bipyridine type photosensitizer has been linked to a manganese(II) dimer via a substituted l-tyrosine, which bridges the manganese ions. The trinu
This paper focuses on challenges in implementation of research in community-based occupational therapy practice. Based on a two-year project in a south Swedish municipality aiming at studying implementation of structured assessment procedures in the housing adaptation process, the first purpose is to provide a detailed project description, and the second is to report on first results identifying c
Soil chemistry under the Solling clean-rain roof was simulated using the dynamic multi-layer soil chemistry model SAFE, including sulfate adsorption. Soil was sampled in order to parameterize the pH and sulfate concentration dependent sulfate adsorption isotherm used in SAFE. Modeled soil solution chemistry was compared to the 14 year long time-series of monthly measurements of soil solution data
A major challenge when designing general purpose graphics hardware is to allow efficient access to texture data. Although different rendering paradigms vary with respect to their data access patterns, there is no flexibility when it comes to data caching provided by the graphics architecture. In this paper we focus on volume ray-casting, and show the benefits of algorithm-aware data caching. Our M
Popular Abstract in Swedish Företagen har mer och mer problem att generera och utveckla kunskaper i samarbete med andra, enskilda företag. Forskare inom det teoretiska område kooperativ inlärning har börjat att undersöka hur partnerorganisationer lär sig att samarbeta med varandra. Men det specifika inlärningsinnehållet av denna kollektivt inlärda kunskap är generellt inte något de fokuserar på. DBusiness organizations increasingly face the problem of how to generate and share knowledge in collaboration with other, separate, business organizations. Researchers in the field of inter-organizational learning have started to study the partner-characteristic, partner-dynamic, and partner-situational factors that influence the process and outcome of such strategic learning collaboration. However
Ultrafast optical response and excitation energy dynamics in light harvesting pigment-protein complexes and in a few model systems have been studied both experimentally and theoretically. Femtosecond light pulses were employed to excite the system and monitor the subsequent time evolution of the transient absorption kinetics and anisotropy. A new form of pump-probe technique was developed for perf
Popular Abstract in Swedish Prostata cancer är en av de vanligast förekommande cancerformerna hos män i västvärlden och den vanligaste förekommande hos män i Sverige. Årligen diagnosticeras i Sverige ungefär 6000 fall och mer än 2000 avlider. Drygt 70% av alla som drabbas är äldre än 70 år medan endast ett fåtal är yngre än 50 år. Sjukdomen ter sig mycket olika hos olika patienter. En del som drabHuman glandular kallikrein 2 (hK2) is a predominantly prostate produced protein with many similarities to prostate-specific antigen (PSA). Just like for PSA elevated levels of hK2 can be found in men with protate cancer. We created an assay where hK2 in serum could reliably and with negligible cross-reactivity with PSA, be measured down to 0.030 ng/mL. The assay measured free hK2 and hK2 complexe
Popular Abstract in Swedish Bildning, bearbetning och upplagring av cathepsin G, proteinas 3 och azurocidin - närbesläktade bakteriedödande proteiner i vita blodkroppar Människans kropp utsätts dagligen för fientliga attacker av olika sorters mikroorganismer, tillhörande bakterie-, virus- eller svampsläktet. Så länge vi är friska och vårt immunförsvar fungerar, kan vi som tur är framgångsrikt fö
A reliable electricity sector is imperative for the development and competitiveness of Costa Rica. During the last decade, electricity demand has been growing faster than the expansion of the power network, and the demand side efforts have been almost inexistent. Therefore, since 2007 the electricity sector of Costa Rica is in a vulnerable position. In fact, for 2014 energy shortages have been ant
Berggrunden i sydvästra Sverige består av bergarter som deformerades och metamorfoserades under den Svekonorvegiska kontinent kollisionshändelsen. Den så kallade ”Sveconorwegian Frontal Deformation Zone” norr om Vättern och Protoginzonen söder därom anses utgöra den östligaste gränsen för Svekonorvegisk omarbetning. Söder om Vättern är Protoginzonen en 20-30 km bred N-S deformationszon. FortsättniThe bedrock in the southwest of Sweden was deformed and metamorphosed during the Sveconorwegian orogeny. The Sveconorwegian Frontal Deformation Zone north of the lake Vättern and the Protogine Zone south of the lake is regarded as the eastmost boundary of Sveconorwegian reworking. South of lake Vättern the Protogine Zone is 20-30 km wide made up of a system of discrete ductile (and locally brittle
En utgrävning gjordes nyligen i övergången mellan kambrium och ordovicium i alunskifferformationen utanför Södra Sandby i Skåne. Under sökandet efter konodonter i en kalkstensbädd från understa ordovicium upptäcktes mikroskopiska sfäruler 0,1-0,5 mm i diameter. Har dessa ett biologiskt ursprung eller har de bildats genom någon rent kemisk/geologisk process? Då det finns stora likheter med rapporteMicroscopic spherules, 0.1-0.5 mm in diameter, from the lowermost Ordovician Rhabdinopora flabelliforme parabola graptolite Zone of the Alum Shale Formation in Södra Sandby, Scania, southern Sweden, have been investigated. The specimens have been studied by light and scanning electron microscopy in order to assess their affin-ity, taphonomic history, and possible relation to metazoan embryos. Diff
The 2009 Lisbon Treaty introduced the Early Warning Mechanism into the EU decision-making process. Under this mechanism, National Parliaments monitor the compliance of EU legislative proposals with the principle of subsidiarity by issuing yellow cards in cases of violation. It is argued that in doing so, they meet a collective action problem in form of an assurance problem, hence will only ineffec
Background: Today, many companies use a cost-based and sometimes competition-based pricing approach. Since academia agrees that value based pricing is superior for creating profit, the problem is not in identifying an ideal pricing strategy, but to understand and facilitate the transformation process towards value-based pricing. Only a limited amount of research has so far been put on understandin
This thesis presents findings from a study about the challenges international master’s degree students have to undergo when they decide to study at Lund University, a university situated in the South of Sweden. The study involved interviews of 7 international students from different national backgrounds. Emerging from the analysis is the perception that respondents have to face several identity ch
