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There is an urgent need for accurate and validated methods to measure plasma phosphorylated tau (p-Tau) biomarkers in Alzheimer’s disease (AD). In this study, we compared the performance of new commercially available plasma p-Tau217 assay developed by ALZpath to other established p-Tau assays in an autopsy-confirmed sample. We included 72 participants from the Arizona Study of Aging and Neurodegen
Background: Disorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from the Global Burden of Disease, Injuries, and Risk Factor Study estimated the burden of 15 neurological conditions in 2015 and 2016, but these analyses did not i
Before performing 177Lu-DOTATATE therapy for neuroendocrine tumors, somatostatin receptor (SSTR) PET imaging is currently used to confirm sufficient tumor SSTR expression, but it also has potential to be used to personalize treatment by predicting absorbed doses to critical organs. This study aims to validate the predictive capability of SSTR PET in anticipating renal absorbed dose in the first cy
Evidence from neuropathological cohorts indicates that a CSF α-synuclein (α-syn) seed amplification assay (SAA) might provide quantitative kinetic parameters correlating with α-syn pathology burden in patients with Lewy body disease (LBD). Studies are needed to assess their longitudinal trend during the presymptomatic and clinical disease phases and their correlation with measures of disease progr
Storm surges combine the power of two natural hazards, strong winds and flooding, and can have devastating effects on people, infrastructure, and nature in coastal areas. Ongoing global changes, including rising sea levels and shifting storm patterns, are expected to increase both the frequency and amplitude of such events in the future. There are, however, significant regional variations and someStorm surges combine the power of two natural hazards, strong winds and flooding, and can have devastating effects on people, infrastructure, and nature in coastal areas. Ongoing global changes, including rising sea levels and shifting storm patterns, are expected to increase both the frequency and amplitude of such events in the future. There are, however, significant regional variations and some
Importance: Traditional adoption studies examine disorder-to-disorder parent-offspring transmission. The role of parental genetic risk in offspring disorder transmission can capture indirect genetic effects from parental genotype to parental phenotype to offspring risk. Objective: To assess the relative importance of genetic and rearing effects from paternal family genetic risk scores (FGRSs) in 3
Background Pulmonary nodules (PNs) are clinically challenging because differentiation between benign and malignant PNs is not possible at CT detection; recurring CT examinations and invasive procedures are often required in PN follow-up. Purpose To investigate PN prevalence in a middle-aged population and the risk factors associated with these nodules. Materials and Methods In this secondary analy
The Particle Finite Element Method (PFEM) is attractive for the simulation of large deformation problems, e.g. in free-surface fluid flows, fluid–structure interaction and in solid mechanics for geotechnical engineering and production processes. During cutting, forming or melting of metal, quasi-incompressible material behaviour is often considered. To circumvent the associated volumetric locking
Background: Up-to-date estimates of stroke burden and attributable risks and their trends at global, regional, and national levels are essential for evidence-based health care, prevention, and resource allocation planning. We aimed to provide such estimates for the period 1990–2021. Methods: We estimated incidence, prevalence, death, and disability-adjusted life-year (DALY) counts and age-standard
I en intervju med publicisten Ken Tyler så beskrev den amerikanska efterkrigskonstnären och abstraktionisten Helen Frankenthaler uppfinnarskapet som en regellös aktivitet: “Så föds konsten, på det sättet sker genombrott. Bryt mot reglerna eller ignorera dem. Det är vad uppfinnarskap handlar om.” Jämfört med juridikens precisa och noggranna metodik så framstår uppfinnandets skapande metod något anThe U.S. painter Helen Frankenthaler, a behemoth of post-war American abstractionist painting, once described the act of inventing as an activity without rules. ”This is how art is born, how breakthroughs happen. Go against the rules or ignore the rules. That is what invention is about”, she is quoted saying in a 1994 interview with legendary publisher Ken Tyler. In contrast with the precise and
The current expansion of mergers and acquisitions forces new postmerged organizational cultures to take form, and requires solid strategies for handling that procedure. Research indicate that at least half of all mergers fail in creating expected synergies, and that the reason for failing is assumed integration issues such as culture clashes. Creating a strong organizational culture is often appoi
Composers? and choreographers? world of ideas. Aspects of the art process. This inquiry is about the artistic process when composing contemporary music and choreographing modern dance. I have studied three composers? and three choreographers? thoughts about the artistic process and the work that leads to a piece of music or a dance. The purpose of the study is to find similarities and differences
Universitetslektor Kontaktinformation E-post: marko [dot] scholze [at] mgeo [dot] lu [dot] seOrganisation Miljö- och geovetenskapliga institutionen (MGeo) Hämtställe: 16 WebbplatsMarko Scholzes profil i Lunds universitets forskningsportalAndra roller Medlem i Strategiskt forskningsområde BECC: Biodiversity and Ecosystem services in a Changing Climate Medlem i Strategiskt forskningsområde MERGE: Mo
https://www.nateko.lu.se/sv/marko-scholze - 2026-07-09
13 November 2025 18:00 to 19:30 | Lecture/talk Hadja Lahbib, European Commissioner for Equality; Preparedness and Crisis Management, has been named the 2025 annual Anna Lindh speaker. On 13 November, she will present ”Strengthening Compliance with International Humanitarian Law in a Fragmented World” Anna Lindh Lecture Event DetailsAnna Lindh Lecture ”Strengthening Compliance with International Hu
Importance: Trastuzumab emtansine (T-DM1) is presently approved for treatment of advanced breast cancer and after incomplete response to neoadjuvant therapy, but the potential of T-DM1 as monotherapy is so far unknown. Objective: To assess pathologic complete response (pCR) to standard neoadjuvant therapy of combination docetaxel, trastuzumab, and pertuzumab (DTP) vs T-DM1 monotherapy in patients
Importance: The association between long sleep duration and mortality appears stronger in East Asian populations than in North American or European populations. Objectives: To assess the sex-specific association between sleep duration and all-cause and major-cause mortality in a pooled longitudinal cohort and to stratify the association by age and body mass index. Design, Setting, and Participants
We introduce an improvement to the FxFx matrix element merging procedure for pp →tt¯ W production at NLO in QCD with one and/or two additional jets. The main modification is an improved treatment of jets that are not logarithmically enhanced in the low transverse-momentum regime. We provide predictions for the inclusive cross section and the tt¯ W differential distributions including parton-shower
During ion sputtering of GaSb(100) surfaces a transient behavior from initial smoothing to roughening accompanied by self-organized pattern formation has been observed using in situ x-ray reflectivity and grazing incidence small angle scattering. The induced patterns show hexagonally ordered nanodot arrays with a spatial periodicity of 30 nm. The correlation length of the pattern increases with io
