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Protein-based microarrays are among the novel class of rapidly emerging proteomic technologies that will allow us to efficiently perform global proteome analysis. However, the process of designing adequate protein microarrays is a major inherent problem. In this study, we have evaluated a protein microarray platform based on nonpurified affinity-tagged single-chain (sc) Fv antibody fragments to ge

A particle-based transported probability density function (PDF) method with a novel chemistry acceleration technique is developed in this work. The technique is based on the chemistry coordinate mapping (CCM) approach that was proposed in our previous works for accelerating direct numerical simulations (DNS) of partially premixed combustion. The method is first validated using Sandia flames D and

Popular Abstract in Swedish Förr trodde man att de delar av genomet som inte uttrycks till proteiner är oviktiga, eftersom man trodde att det nästan uteslutande är proteinerna som utför de nödvändiga funktionerna i cellen. Man kände till att DNA och RNA innehåller information om hur proteiner ska se ut och när de ska uttryckas, men man kände bara till ett fåtal andra uppgifter som RNA har i cellen

Abstract Title: The video surveillance industry in the USA - the future development and the technology shift Seminar date: 4/6 - 2010 Course: FEKP01, Degree Project Graduate Level, Business Administration, Graduate Level, 15 University Credit Points (ECTS-cr) Authors: Johan Lindgren and Marc Palm Mentor: Thomas Kalling Key words: Technology shift, Video surveillance industry, Organizational Learni

Objective To compare, in young active adults with an acute anterior cruciate ligament (ACL) tear, the mid-term (five year) patient reported and radiographic outcomes between those treated with rehabilitation plus early ACL reconstruction and those treated with rehabilitation and optional delayed ACL reconstruction. Design Extended follow-up of prospective randomised controlled trial. Setting Ortho

Ten countries have established quotas for female representation on publicly traded corporate and/or state-owned enterprise boards of directors, ranging from 33 to 50 %, with various sanctions. Fifteen other countries have introduced non-binding gender quotas in their corporate governance codes enforcing a "comply or explain" principle. Countless other countries' leaders and policy groups are in th

BACKGROUND: Despite marked improvement in therapy and monitoring of patients with insulin-dependent (type 1) diabetes, diabetic nephropathy remains a serious complication, with subsequent end-stage renal disease in about 20% of cases. OBJECTIVE: To investigate in young patients with type 1 diabetes whether urine α-Glutathione S-transferase to creatinine ratio (α-GST:crea) relates to markers of s

BACKGROUND & AIMS: Little is known about recurrence of pancreatitis after an initial episode, and little is known about how the disease progresses or what factors affect progression. We performed a population-based study of patients with acute pancreatitis (AP) to determine their outcomes and associated factors. METHODS: We performed a retrospective study of patients with first-time AP from 20

Sex hormone-binding globulin (SHBG) is a glycoprotein responsible for the transport and biologic availability of sex steroid hormones, primarily testosterone and estradiol. SHBG has been associated with chronic diseases including type 2 diabetes (T2D) and with hormone-sensitive cancers such as breast and prostate cancer. We performed a genome-wide association study (GWAS) meta-analysis of 21,791 i

The Department of English in Lund: Working Papers in Linguistics is an annual volume produced by the English Department at Lund University in Sweden. Its main aim is to publicize research being carried out by staff and post-graduate students in the department, but we are also pleased to include contributions from members of neighbouring departments and universities. The contributions in volume 3

Background: Low-level processing and normalization of microarray data are most important steps in microarray analysis, which have profound impact on downstream analysis. Multiple methods have been suggested to date, but it is not clear which is the best. It is therefore important to further study the different normalization methods in detail and the nature of microarray data in general. Results: A

The principal fate during litter decomposition and mineralization is rather well established only for a limited number of elements, mainly essential plant nutrients and a few potentially very toxic metals. Elements which occupy the majority of the positions in the periodical system seems almost unknown in this context. The objectives were, therefore to assess differences in the behavior of 58 mine

Popular Abstract in Swedish Denna studie behandlar huvudsakligen hur företagen väljer att anpassa sig till myndigheternas krav utifrån miljöskyddslagen. Undersökningen fångar en viss historisk tidpunkt då lagstiftning och myndigheter har en viktig betydelse. Det är en mycket dramatisk fas av den miljöekonomiska utvecklingen. I samhället har man inte tidigare artikulerat miljökraven på ett sådant sThis study primarily focuses on the ways in which companies choose to adapt themselves to the demands of the authorities as based on the Swedish environmental protection act. The time during which the burden upon nature became a serious, important question for companies is a very dramatic phase of a historical process. Before the arrival of more comprehensive legislation, no loads upon nature were

The regional sensitivity of different vascular beds to i.v. CGRP was investigated in the albino rabbit by using the microsphere method. Experiments were performed without pre-treatment on both conscious and pentobarbital-anaesthetized animals. In addition, in one series on conscious animals, rabbits were pre-treated with indomethacin in order to reduce the formation of prostaglandins. In another s

The expression and activities of constitutive nitric oxide synthase (cNOS) and inducible nitric oxide synthase (iNOS) in relation to insulin and glucagon secretory mechanisms were investigated in islets isolated from rats subjected to total parenteral nutrition (TPN) for 10 d. TPN is known to result in significantly increased levels of plasma lipids during the infusion time. In comparison with isl

Lyme borreliosis (LB) is the most common vector-borne disease in the northern hemisphere, and southern Sweden is a highly endemic area. In over 70% of the cases, LB is represented by the non-disseminated cutaneous form erythema migrans (EM). This thesis has its focus on EM from a primary health care perspective in southern Sweden, including aspects on epidemiology, the clinical picture, gender dif

Popular Abstract in Swedish Denna avhandling handlar om expertinflytande och demokrati och fokuserar hur politiskt beslutsfattande i frågor med stort beroende av vetenskaplig expertis bör gå till för att vara demokratiskt. Studiens övergripande syfte är att från ett demokratiskt perspektiv värdera den svenska lagstiftningsprocessen om medicinsk genteknik, som kan ses som ett fall av beslutsfattand

Popular Abstract in Swedish Detta arbete handlar om utvecklingsneurobiologi. Ett långt ord men så beskriver det också precis vad det rör sig om: biologiska studier rörande nervsystemets utveckling. Generellt sett kan man säga att utvecklings-neurobiologisk forskning på lång sikt syftar till att förstå nervsystemets utveckling såpass väl att man skall kunna använda denna kunskap för att reparera etThe striatum is part of the telencephalon, the most anterior part of the vertebrate brain. From when it first can be identified, telencephalic morphology is highly complex and a wide range of mechanisms has been suggested to participate in its induction, patterning and neurogenesis. Sonic hedgehog (shh), a gene coding for a secreted protein has been suggested to be required for ventral telencephal

Popular Abstract in Swedish Modern gastroenterologi är till stora delar helt beroende av resultat från gastrointestinal endoskopi och många av de sjukdomar som hänförs till denna specialitet kan också behandlas med modern endoskopisk och minimal invasiv teknik. Gastroskopi är förstahandsundersökning av patienter med såväl kroniska som akuta symptom från övre gastrointestinalkanalen. Den gastroskopChromoendoscopy, endoscopic tissue staining, is an adjunctive method using chemical agents applied to the mucosal surface in order to aid gastrointestinal endoscopic diagnosis and therapy. Acid producing mucosa in the GI tract may be visualized endoscopically by Congo red staining in combination with stimulation of gastric acid production. Congo red is a reactive indicator dye that changes color f

The orbit of a planet is surrounded by a chaotic zone wherein nearby particles' orbits are chaotic and unstable. It was shown by Wisdom that the chaos is driven by the overlapping of mean motion resonances which occurs within a distance (δa/a)chaos≈ 1.3μ^2/7 of the planet's orbit. However, the width of mean motion resonances grows with the particles' eccentricity, which will increase the width of