Evaluation of Novel DNA Adenine Methyltransferase Fusion Construct Designs for Enhancer Mapping in Human Cells
Enhancers are central regulators of cell-type-specific gene expression, yet direct functional mapping of active enhancer-promoter interactions in single cells remains technically challenging. DNA adenine methyltransferase (Dam)-based chromatin recording offers a strategy to mark genomic regions proximal to proteins associated with active transcription sites in vivo, including enhancer regions, and
