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The objective of this work was to examine the atazanavir-bilirubin relationship using a population-based approach and to assess the possible application of bilirubin as a readily available marker of atazanavir exposure. A model of atazanavir exposure and its concentration-dependent effect on bilirubin levels was developed based on 200 atazanavir and 361 bilirubin samples from 82 patients receiving

Isomeric states in the semimagic Sn128-130 isotopes were populated in the fragmentation of a Xe-136 beam on a Be-9 target at an energy of 750 A.MeV. The decay of an isomeric state in Sn-128 at an excitation energy of 4098 keV has been observed. Its half live has been determined to be T-1/2 = 220(30) ns from the time distributions of the delayed gamma rays emitted in its decay. gamma gamma coincide

Encouraging innovation is becoming more important for countries in order to sustain economic growth, performance and competitiveness in a world of fierce marketplace competition. However, previous studies and research reveal that there is a worldwide decline in innovation within organizations. This paper seeks to discover what’s behind this, and what’s hindering knowledge intensive firms from bein

Close international collaboration between pediatric oncologists has led to marked improvements in the cure of patients, seen as a long-term overall survival rate of about 80%. Despite this progress, neuroblastoma remains a challenging disease for both clinicians and researchers. Major clinical problems include lack of acceptable cure rates in high-risk neuroblastoma and potential overtreatment of

Popular Abstract in Swedish Atomspektra har varit ett viktigt forskningsområde inom fysiken sedan mitten av 1800-talet. Då elektromagnetisk strålning, såsom synligt ljus, ultraviolett- och röntgenstrålning, är unik för varje grundämne ger ett observerat spektrum information om vilka slags atomer som emitterar strålningen. Exempelvis så visar spektra av ett vanligt lysrör att ljuset kommer från kviThe spectra of highly charged tungsten ions have been investigated using x-ray and extreme ultraviolet spectroscopy. These heavy ions are of interest in relativistic atomic structure theory, where high-precision wavelength measurements benchmark theoretical approaches, and in magnetic fusion research, where the ions may serve to diagnose high-temperature plasmas. The work details spectroscopic in

This article aims to expand our understanding of projectification in Swedish municipalities. Above all the article explores to what extent processes of projectification can be identified and if so how they unfold. The article draws its inspiration from critical management studies and uses the notion of sensemaking to identify the practices of projectification processes. Three processes of projecti

Assisterad befruktning har, vid sidan av internationella adoptioner, kommit att skapa möjligheter framför allt för de som lider av ofrivillig barnlöshet, att bilda familjer som inte är baserade på genetiska eller biologiska band. De olika metoderna för behandling av ofrivillig barnlöshet ger upphov till en rad etiska och juridiska frågor, bland annat om vilka metoder som ska tillåtas och vilka kraAssisted reproductive technology has, in addition to international adoptions, come to create opportunities, particularly for those who suffer from infertility, to form families that are not based on genetic or biological ties. The various methods of treating infertility raises a number of ethical and legal issues, including what methods are to be permitted and the requirements that must be met in

Sammanfattning I Europakonventionen artikel 8 skyddas rätten till privatliv. Varje person har rätt till skydd av personuppgifter som tillhör honom eller henne. Globalisering och teknologisk utveckling har anmärkningsvärt förändrat sättet på hur personuppgifter behandlas. En uppdaterad lagstiftning för personuppgiftsskydd behövs och EUs föreslagna förordning reflekterar tydligt utmaningarna för Summary The protection of personal data is a fundamental right in accordance with Article 8 of the European Convention of Human Rights. Every person has the right to the protection of information that concerns him or her. Globalisation and technological advancements have enormously transformed the way our personal data is collected. An updated legislation on data protection is needed and the pr

Dagens TV-program bygger i de flesta fall på ett bakomliggande TV-format. Formaten har under de senaste åren blivit en allt viktigare del av TV-industrin och idag är de föremål för en handel som årligen omsätter miljardbelopp. I takt med att marknaden för format expanderat har ökande konkurrens inom mediebranschen gjort att striden om TV-tittarna hårdnat. TV-bolagen har tvingats fokusera allt mer The television programs of today are in most cases based on an underlying television format. The use of TV formats has in recent years become an increasingly important part of the television industry and today they are subject of a billion dollar trade. As a result of the format market's expansion and the increased competition within the media industry the battle for viewers has intensified. T

Swedish National Board of Housing, Building and Planning reported in "Energi i bebyggelsen"that 80 % of the detached houses in Sweden were under-ventilated, and had a flow of 0.23 l/(s·m2) on average instead of, by the code, required 0,35 l/(s·m2). Well known concerns here are lacking indoor environmental quality and a risk of moisture problems in certain rooms and in the envelope. The naturally v

The parameters to extract polysaccharide-enriched fractions (PEF) from mushrooms using MAE (microwave-assisted extraction) were adjusted following a full factorial 3 2 experimental design. The highest yield and total carbohydrate values, using Lentinula edodes as model mushroom, were obtained at 180 °C and 30 min. Several mushroom species were submitted to MAE and their PEF yields ranged between

Exposure levels to staff in interventional radiology (IR) may be significant and appropriate assessment of radiation doses is needed. Issues regarding measurements using physical dosemeters in the clinical environment still exist. The objective of this work was to explore the prerequisites for assessing staff radiation dose, based on simulations only. Personal dose equivalent, Hp(10), was assessed

The largest dune fields in Sweden and Norway are small in international comparison but still form distinct parts of this previously glaciated landscape. The dunes formed c.10.5-9 ka ago, shortly after the last deglaciation, when winds close to the ice sheet were strong and vegetation was largely absent [1-4]. Since then they have been more or less stable and today they are covered by forest. Most

We present high-order harmonic generation results obtained with different laser systems a 1 ps 1053 nm Nd-glass laser a 2 ps 616 nm synchronously pumped dye laser a 36 ps 1064 nm mode-locked Nd-YAG laser and the second harmonics (308 nm and 532 nm) of the latter two systems. We investigate the influence of the laser pulse width the excitation wavelength (from the near infrared to the ultraviolet)

Silicon pixel detectors are at the core of the current and planned upgrade of the ATLAS experiment at the LHC. Given their close proximity to the interaction point, these detectors will be exposed to an unprecedented amount of radiation over their lifetime. The current pixel detector will receive damage from non-ionizing radiation in excess of 1015 1 MeV neq/cm2, while the pixel detector designed

Populärvetenskaplig sammanfattningAluminium används för en stor mängd produkter, allt från hus och i fordon till såvardagliga produkter som aluminiumburkar. Det breda användningsområdet beror på aluminiumets höga hållfasthet, lätta vikt och dess goda korrosionsmotståndighet. Korrosionsmotståndet beror på att när aluminium exponeras för luft bildas ett aluminiumoxidskikt på ytan, vilket skyddar aluAbstractIn this thesis, the electrochemical deposition process of Sn into ordered nanoporous anodic aluminium oxide (NP-AAO) have been studied. The deposition process was studied in situ using the X-ray techniques: X-ray diffraction (XRD), Grazing incidence Transmission Small-Angle X-ray Scattering (GTSAXS), X-ray Fluorescence (XRF) and X-ray Absorption Near Edge Structure (XANES) and ex situ usin

Most stomatopod crustaceans have complex retinas in their compound eyes, with up to 16 spectral types of photoreceptors, but members of the superfamily Squilloidea have much simpler retinas, thought to contain a single photoreceptor spectral class. In the Atlantic stomatopod Squilla empusa, microspectrophotometry shows that all photoreceptors absorb light maximally at 517 nm, indicating that a sin