Filtyp
Background: The routine use of sedation and analgesia during post-cardiac arrest care and its association with clinical outcomes remain unclear. This study aimed to describe the use of sedatives and analgesics in post-cardiac arrest care, and evaluate associations with good functional outcome, survival, clinical seizures, and late awakening. Methods: This was a post hoc analysis of the TTM2-trial,
OBJECTIVES: the purpose of this study was to assess the predictive accuracy of conventional cardiovascular risk factors for incident heart failure and atrial fibrillation, and the added benefit of multiple biomarkers reflecting diverse pathophysiological pathways. BACKGROUND: heart failure and atrial fibrillation are interrelated cardiac diseases associated with substantial morbidity and mortality
Purpose: To evaluate patients with central retinal vein occlusion (CRVO) and neovascular glaucoma (NVG) using electrophysiology in order to gain better understanding of visual outcome and risk factors, such as previously diagnosed primary open-angle glaucoma (POAG). Methods: Eighty-three patients (83 eyes) initially presenting with CRVO and examined with full-field electroretinography (ERG) within
The development in sensor technology has made many wastewater treatment systems data rich but not necessarily information rich. To extract the adequate information from several sensors is not trivial, and it is not sufficient to consider only the time series. Different tools for detecting unusual on-line measurement data and deviating process behaviour are discussed. In this paper various dimensio
Background The impact of the prophylactic vaccine against human papillomavirus (HPV) types 6, 11, 16, and 18 (HPV6/11/16/18) on all HPV-associated genital disease was investigated in a population that approximates sexually naive women in that they were "negative to 14 HPV types" and in a mixed population of HPV-exposed and -unexposed women (intention-to-treat group). Methods This analysis studied
Overview: Prostate cancer (PC)is the most common cancer in Sweden, and the leading cause of cancer death. Positronemission tomography with x-ray computed tomography (PET/CT) is an important imagingmethod for many cancers. A group of PET radiopharmaceuticals known as PSMA(prostate specific membrane antigen) ligands has been introduced for imaging ofPC. This thesis investigates aspects of the ligand
Background: Gallbladder cancer (GBC) is rare but aggressive. The extent of surgical intervention for different GBC stages is non-uniform, ranging from cholecystectomy alone to extended resections including major hepatectomy, resection of adjacent organs and routine extrahepatic bile duct resection (EBDR). Robust evidence here is lacking, however, and survival benefit poorly defined. This study ass
In ST-elevation myocardial infarction (STEMI), thrombus material is often present in partial or total coronary occlusion of the coronary vessel. However, prior to the thrombus aspiration during ST-Segment Elevation Myocardial Infarction in Scandinavia (TASTE) trial, it remained unclear whether routine thrombus aspiration during percutaneous coronary intervention (PCI) treatment of STEMI would resu
New robot applications increasingly require external sensing to accomplish robustness and performance despite the variations and uncertainties that come with the increasing demands on flexibility for manufacturing of customized products. The demands on productivity then require high performance, which for well known feedback-control reasons means short response times from external process event to
Background: Myocardium at risk (MaR) can be evaluated by cardiovascular magnetic resonance (CMR) imaging using contrast-enhanced steady state free precession (CE-SSFP) in patients after ST-elevation myocardial infarction (STEMI). However, CE-SSFP utilizes gadolinium contrast, which is contraindicated in patients with severe renal insufficiency. Native T1-mapping is a non-contrast CMR method which
Background: Magnetic resonance imaging (MRI) has traditionally been preferred over computed tomography (CT) for segmentation of intracranial structures due to its superior low contrast resolution. However, a reliable CT-based segmentation could improve patient management when MRI is not practical. Despite advancements in CT imaging, such as enhanced tissue differentiation using virtual monoenerget
Background: Mammography screening programmes have been widely implemented across European countries over the past 40 years with the main aim to detect breast cancer earlier and thereby reduce breast cancer mortality. This study aimed to analyse and compare changes over time in breast cancer incidence, by stage at diagnosis, and breast cancer mortality across countries in relation to the timing of
The training of the state-of-the-art Deep Neural Networks (DNNs) consumes massive amounts of energy, while the human brain learns new tasks with remarkable efficiency. Currently, the training of DNNs relies almost exclusively on Backpropagation (BP). However, BP faces criticism due to its biologically implausible nature, underscoring the significant disparity in performance and energy efficiency b
BACKGROUND: Early-life exposure to per- and polyfluoroalkyl substances (PFAS) may impact the developing lungs and immune system and increase the risk of childhood asthma, but no studies have been conducted in a high-exposed population. The objective of this study was to estimate associations between prenatal PFAS exposure and childhood incidence of asthma and wheeze in Blekinge County, Sweden, whe
Consider a quadratic form of a vector valued differentiable stationary Gaussian process. The crossing intensity of a fixed level depends on the joint correlation structure of the process and its derivative, but no simple exact form is known for the general case. We give the first and second terms in an asymptotic expansion, which is valid as the level tends to infinity, and show how to find higher
Popular Abstract in Swedish Detta arbete handlar om utvecklingsneurobiologi. Ett långt ord men så beskriver det också precis vad det rör sig om: biologiska studier rörande nervsystemets utveckling. Generellt sett kan man säga att utvecklings-neurobiologisk forskning på lång sikt syftar till att förstå nervsystemets utveckling såpass väl att man skall kunna använda denna kunskap för att reparera etThe striatum is part of the telencephalon, the most anterior part of the vertebrate brain. From when it first can be identified, telencephalic morphology is highly complex and a wide range of mechanisms has been suggested to participate in its induction, patterning and neurogenesis. Sonic hedgehog (shh), a gene coding for a secreted protein has been suggested to be required for ventral telencephal
A new Regulation on nutrition and health claims came into force in 2007 with implementation during a three-year period and will harmonise this area within the European Community. It makes provision for health claims on foods, including reduction of disease risk claims, and thus recognises the importance of food and nutrition for health. Member states have provided suggestions for claims regarding
Popular Abstract in Swedish Levande organismer, inklusive människor, har en 14C/12C-kvot som återspeglar miljön. När materialet dör slutar kroppen att fylla på 14C och kroppens 14C börjar sönderfalla till 14N. Detta gav upphov till den klassiska 14C-dateringsmetoden, vilken utvecklades av professor W.F. Libby, 1949 och gav honom Nobelpriset i kemi 1960. 14C-datering används huvudsakligen inom arkeThe testing of nuclear weapons in the atmosphere, in the middle of the 20'h century, resulted in a bomb-pulse excess of atmospheric 14C. A bomb-pulse dating method was thus developed. The latter is a method to determine the time of formation of formerly living modern (i.e. living after 1955) material , based on the 14C/ 12C ratio in it. The objective of this work was to evaluate the factors that c
Popular Abstract in Swedish Modern gastroenterologi är till stora delar helt beroende av resultat från gastrointestinal endoskopi och många av de sjukdomar som hänförs till denna specialitet kan också behandlas med modern endoskopisk och minimal invasiv teknik. Gastroskopi är förstahandsundersökning av patienter med såväl kroniska som akuta symptom från övre gastrointestinalkanalen. Den gastroskopChromoendoscopy, endoscopic tissue staining, is an adjunctive method using chemical agents applied to the mucosal surface in order to aid gastrointestinal endoscopic diagnosis and therapy. Acid producing mucosa in the GI tract may be visualized endoscopically by Congo red staining in combination with stimulation of gastric acid production. Congo red is a reactive indicator dye that changes color f
