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The objective of this work was to examine the atazanavir-bilirubin relationship using a population-based approach and to assess the possible application of bilirubin as a readily available marker of atazanavir exposure. A model of atazanavir exposure and its concentration-dependent effect on bilirubin levels was developed based on 200 atazanavir and 361 bilirubin samples from 82 patients receiving
Isomeric states in the semimagic Sn128-130 isotopes were populated in the fragmentation of a Xe-136 beam on a Be-9 target at an energy of 750 A.MeV. The decay of an isomeric state in Sn-128 at an excitation energy of 4098 keV has been observed. Its half live has been determined to be T-1/2 = 220(30) ns from the time distributions of the delayed gamma rays emitted in its decay. gamma gamma coincide
Genome-wide association studies have revealed >60 loci associated with type 2 diabetes (T2D), but the underlying causal variants and functional mechanisms remain largely elusive. Although variants in TCF7L2 confer the strongest risk of T2D among common variants by presumed effects on islet function, the molecular mechanisms are not yet well understood. Using RNA-sequencing, we have identified a TC
A method for determination of the accessible volume fraction in gels as function of the molecular weight of the solutes is presented. The pore-size distribution is determined by measuring the rate of diffusion of a mixture of solutes into a gel using gel filtration for separation. The solutes, of various sizes, are detected by refractive index measurements. Two marker molecules (blue dextran and g
One of the most important factors governing durability of concrete structures is reinforcement corrosion, and to prevent degradation associated with it, it is desirable to use large concrete covers. However, if the concrete cover is increased, the majority of design methods will predict that the crack widths at the concrete surface increase significantly. This can be contradictory, since the same
Exposure levels to staff in interventional radiology (IR) may be significant and appropriate assessment of radiation doses is needed. Issues regarding measurements using physical dosemeters in the clinical environment still exist. The objective of this work was to explore the prerequisites for assessing staff radiation dose, based on simulations only. Personal dose equivalent, Hp(10), was assessed
The conversion of technical lignin into valuable chemicals is important for the complete utilization of lignocellulose. The kraft process dominates the pulp industry, and large amounts of kraft lignin are produced worldwide. However, the complexity of lignin limits its valorization. In this study, a kraft lignin, Indulin AT, was depolymerized under base conditions, and the effects of substrate loa
Objectives. At the request of the European Commission and in the framework of the European Machinery Directive, research was conducted jointly in five different laboratories to develop specifications for surface temperature limit values for the gripping and handling of cold items. Methods. Four hundred and fourteen experiments were run where male and female subjects were invited to grip for up to
Titan aluminium alloys belong to the group of α–β-alloys, which are used for many applications in industry due to their advantageous mechanical properties, e.g. for laser powder bed fusion (PBF-LB) processes. However, the composition of the crystal structure and the respective magnitude of the solid fraction highly influences the material properties of titan aluminium alloys. Specifically, the the
We build a model to predict from first principles the properties of major mergers. We predict these from the coalescence of peaks and saddle points in the vicinity of a given larger peak, as one increases the smoothing scale in the initial linear density field as a proxy for cosmic time. To refine our results, we also ensure, using a suite of ∼400 power-law Gaussian random fields smoothed at ∼30 d
I Hanöbukten utanför Haväng i sydöstra Skåne finns välbevarade undervattenslämningar från ett mesolitiskt landskap med rester av träd och sediment avsatta i å- och lagunmiljö. Arkeologiska fynd av bland annat stationära fiskeredskap och en hackyxa av horn har gjorts. Landskapet formades under lågvattenperioderna under Yoldiahavet (11 700-10 800 cal BP) och Littorinahavets första fas (9800-8500 calIn the Hanö bay off the coast at Haväng in SE Scania, southern Sweden, a submerged and well-preserved Mesolithic landscape is found, including remains of trees, river and lagoon sediments, and archaeological artefacts such as an antler pick axe and stationary fishing constructions. The landscape was formed during the Yoldia Sea (11,700-10,800 cal BP) and Initial Littorina Sea (9800-8500) low-water
Ett barn med funktionsnedsättning kan ansöka om bistånd för att avlasta föräldrarna i vårdnadsansvaret. Vid bedömning om bistånd ska beviljas eller inte, ska beslutsfattaren bedöma föräldraansvarets omfattning. Föräldraansvaret är ett begrepp som syftar till att jämföra det ansvar en förälder till ett barn med funktionsnedsättning har och det ansvar en förälder till ett barn utan funktionsnedsättnA child with functional impairment can apply for social assistance in order to relieve their parents from the responsibility of care to either Social Services Act (2011:453) (SoL) or Support and Service for Person with Certain Functional Impairments act (1993:387) (LSS). During the assessment of whether the social assistance shall be granted or not, the decision-making officer must assess the scop
Den europeiska gemenskapen inom försvars-och säkerhetsfrågor rör sig allt mer ifrån transnationellt samarbete mot federal integration. Parallellt med denna utveckling identifieras på EU-nivå i dagsläget dessutom en rad nya säkerhetspolitiska utmaningar som både unionen och medlemsstaterna till stor del är överens om att hantera gemensamt. Likväl förekommer också att krav ställs på mer nationellt sThe European Community in the fields of defence and security is at large moving further and further from transnational cooperation towards federal integration. In line with this development, a number of new security policy challenges have today been identified at EU level and both the EU and a majority of its member states agree that they need to be addressed jointly. Nevertheless, demands from me
Syftet med examensarbetet är att studera ledarskapet och ledarens roll i förändringsarbetet mot ett klimatneutralt byggande. I studien utreds vilka faktorer som driver förändringsarbetet mot ett klimatneutralt byggande och hur miljöarbetet kan bli mer attraktivt för anställda i svenska byggföretag. Studien har utförts på ett fallföretag och ett av deras projekt i produktionsfasen. En kvalitativ mThe purpose of this master thesis is to study the leadership and the roll of the leader during a change in the process towards a climate neutral construction process. The study is aiming to find factors which affects the change process towards a climate neutral construction process as well as how the environmental work can become more attractive in projects. The study has been carried out as a ca
Oil is very important for today’s society and the transportation sector is almost completely dependent on this material. Unfortunately, it affects the level of greenhouse gases negatively which in turn contribute to global warming. Therefore, it is necessary to reduce greenhouse gas emissions, especially in the sectors that emit the most, as transportation sector. The European Parliament has decid
Scholars discuss about the importance of processes of communication in which all stakeholders actively participate influencing the constitution and development of change and organizations. However, communication professionals struggle to em-brace these assumptions and modify their roles and practices in these complex set-tings. This study aims to understand how practitioners adapt their roles in t
This paper examines relocation of taxpayers during 2000 to 2021 across Swedish local work regions and its implications on the tax system. There exist 290 mu- nicipalities in Sweden, which are divided into 67 local work regions. Relocation is categorised as either relocation within or outside local work regions. Furthermore, a distinction is made between age and income groups in order to capture po
Artificial neural networks are, again, on the rise. The decreasing costs of computing power and the availability of big data together with advancements of neural network theory have made this possible. In this thesis, LSTM (long short-term memory) recurrent neural networks are used in order to perform financial time series forecasting on return data of three stock indices. The indices are S&P
Samhället idag kännetecknas av digital interaktion, där både privata såväl som yrkesmässiga kontakter sker via olika tekniska plattformar. Människor skrol-lar, kommunicerar och tar till sig information via mobiltelefoner eller datorer vilket har blivit det normala sättet att interagera i vardagen. Allt fler rättsområ-den har tagit digitaliseringen i beaktning, men det finns fortfarande rättsområ-dSociety today is characterized by digital interaction, with both private and pro-fessional contacts taking place through various technological platforms. Peo-ple browse, communicate and absorb information via mobile phones or com-puters, which has become the normal way of interacting in everyday life. More and more areas of law have taken digitalization into account, but there are still areas of l
