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BACKGROUND: Glibenclamide (Gb) may provoke long-lasting hypoglycaemic reactions, and one of the known risk factors is impaired renal function. We have demonstrated Gb to have a terminal elimination half-life of 15 h, and the main metabolites have a hypoglycaemic effect. With few exceptions, detailed studies on second generation sulphonylureas in diabetics with impaired renal function are lacking.

BACKGROUND: Patients on dialysis who have an acute myocardial infarction (AMI) have an exceedingly poor prognosis, but it is unknown to what extent guideline-recommended interventions and treatments are used and to which benefit. We aimed to assess temporal changes in the use of treatments and survival rates in dialysis patients with an AMI. METHODS AND RESULTS: All consecutive AMI cases from 1996

Background and ObjectivesIdentifying a clinically meaningful change in cognitive test score is essential when using cognition as an outcome in clinical trials. This is especially relevant because clinical trials increasingly feature novel composites of cognitive tests. Our primary objective was to establish minimal clinically important differences (MCIDs) for commonly used cognitive tests, using a

BACKGROUND: This is an open-label, single-arm, single-center pilot study using 7-Tesla in vivo proton magnetic resonance spectroscopy (1H MRS) to measure brain cortical glutathione concentration at baseline before and during the use of oral fumarates as a disease-modifying therapy for multiple sclerosis. The primary endpoint of this research was the change in prefrontal cortex glutathione concentr

OBJECTIVE: To study cause specific mortality and cancer morbidity in workers exposed to the dust of grinding materials, grinding agents, and stainless steel, especially with regard to a possibly increased risk of respiratory, stomach, and colorectal cancer. METHODS: Retrospective cohort study, using reference cohorts of blue collar workers and population rates for comparison. The exposed cohort c

Background: The time spent in nursing homes (NHs) by patients with Alzheimer’s disease (AD) might be influenced by many factors, e.g., sociodemographic and clinical characteristics, rate of disease progression, and concomitant disorders. Whether different aspects of cholinesterase inhibitor (ChEI) therapy (drug agent, dose, and duration) affect time spent in NHs has not been investigated. We studi

In late 2016, Lund is on the verge of becoming the center of accelerator-based material science in Europe.The MAX IV Laboratory, an electron synchrotron, was inaugurated in June 2016 with a scientific program to commence shortly and the European Spallation Source ERIC (ESS), a spallation neutron source, is presently under construction and anticipated to be fully operational by 2022.These facilitieThe He-3 “crisis” has become a fact in the last decade and large scale neutron detectors based on He-3 technologies have become unaffordable. This new He-3 reality has resulted in a major effort worldwide to develop replacement neutron-detector technologies. Many of these technologies are in their infancy and need to be thoroughly tested before becoming mainstream, while others are approaching com

Aim of the study Predicting outcome of unconscious patients after successful resuscitation is challenging and better prognostic markers are highly needed. Ischemic heart disease is a common cause of out-of-hospital cardiac arrest (OHCA). Whether or not high-sensitivity troponin T (hs-TnT) is a prognostic marker among survivors of OHCA with both ischemic and non-ischemic aetiologies remains to be d

Background High parity has been suggested to increase risk of maternal cardiovascular disease independent of body mass index measured after childbearing. Pregnancy is, however, associated with persistent weight gain and metabolic changes that, independent of parity, increase the risk of cardiovascular disease. It could therefore be questioned if high parity independently increases the risk of card

Background: Opioid use disorder is a chronic disorder with a high risk of overdose-related morbidity and mortality where a large proportion of these can be averted by timely administration of the antidote naloxone. For naloxone to be present when and where overdoses occur, broad-scale overdose education and naloxone distribution (OEND) must be established. A regional naloxone program was implement

AIMS: Metformin has hitherto not been proven superior to other type 2 diabetes (T2D) medications for the prevention of organ complications. The aim of this study is to report baseline data and blinded interim analyses in the register-based randomised clinical trial (RRCT) SMARTEST, which compares metformin and the SGLT2 inhibitor dapagliflozin in early T2D. We also present learnings from the novel

X-ray ptychography is a powerful and robust coherent imaging method providing access to the complex object and probe (illumination). Ptychography reconstruction is typically performed using first-order methods due to their computational efficiency. Higher-order methods, while potentially more accurate, are often prohibitively expensive in terms of computation. In this study, we present a mathemati

Background: Various plasma phosphorylated tau species have been shown to be associated with amyloid-β (Aβ) PET and Tau PET in Alzheimer’s disease (AD), but whether APOE ε4 affects the interaction between glial fibrillary acidic protein (GFAP) and phosphorylated tau (pTau), and whether a three-way interaction exists among APOE ε4, GFAP, and pTau that influences AD progression remain unclear. Method

BACKGROUND: Differences in cardiac sarcoidosis between racial groups remain understudied. Therefore, this study aims to explore race differences in patients with cardiac sarcoidosis. METHODS: We analyzed data from the Cardiac Sarcoidosis Consortium, an international registry including over 25 centers. The primary clinical outcome was a composite end point of all-cause mortality, left ventricular a

Background: Hearing loss is estimated to affect more than 20% of the global population. Hearing aid fitting is a common intervention in audiological rehabilitation; however, there are still those who struggle with remaining communication difficulties that require additional intervention. The group rehabilitation program Active Communication Education (ACE) has been shown to be an effective alterna

Lum nr 4/08 LUM Lunds universitets magasin | Nr 4 | 2008 Antika gudar får nytt hem Nya enzym lovande mot folksjukdomar finns sUperrektorn? Ranking på gott och ont 2 LUM nr 4 | 2008 bysthåLLare LUM nr 4 | 2008 3 En underkropp här, ett huvud där och en överkropp lite vid sidan om. Det är lite si och så med värdighe- ten bland antikens gudar inför flyt- ten från Klassiska institutionen till Historisk

https://www.lu.se/sites/www.lu.se/files/lunds-universitets-magasin-4-2008.pdf - 2026-06-08

Spontanopera LUNDS UNIVERSITETS MAGASIN | NR 6 | 2017 FÖRSTA DOKTORN UT I IMPROVISERAD SÅNG Så hanterar du skitstövlar på jobbet Nytt centrum satsar på forskarpar Livet efter utmattningen 2 LUM NR 6 | 2017 LUM NR 6 | 2017 3 Lunds universitets första gemen- samma hemvändarhelg någonsin hölls i oktober i 350-årsjubileets glans. Tvåhundra alumner åter- vände för att välja och vraka ur ett späckat pro

https://www.lu.se/sites/www.lu.se/files/lunds-universitets-magasin-6-2017.pdf - 2026-06-08

Bakgrund till berättelser om energi Från utbildningssynpunkt tycks det finnas fyra aspekter som är relevanta när man undervisar om energi i grundsko- lan: Energi som begrepp, energibesparing, förnyelsebar energi och energieffektivitet. Denna historiska bakgrund ska ligga till grund för berättelser som kan användas var för sig eller i kombination med varandra. Med hjälp av berättel- serna kan lärar

https://www.nrcf.lu.se/sites/nrcf.lu.se/files/2025-11/Bakgrund_till_beraettelser_om_energi_0.pdf - 2026-06-08

https://laminate.ht.lu.se/events/event/laminate-talks-kara-morgan-short-individual-difference-neurocognitive-processing-adult-learned/ - 2026-05-16