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Matrix metalloproteinases (MMPs) play an important role in the pathological processes of degradation of extracellular matrix and destruction of basement membrane, which leads to tumor invasion and metastasis. In the present study, we investigated membrane-type 2 MMP (MT2-MMP) expression pattern in esophageal cancer tissues collected from 103 patients, and explored MT2-MMP expression pattern in cor
The thesis explores the obligation in international law to protect the ecological integrity of transboundary watercourses. The thesis specifically examines the obligation to protect environmental flows, which essentially means to protect a certain water flow for the benefit of freshwater ecosystems and the ecosystem services they supply. The obligation to protect the integrity of transboundary watThe thesis explores the obligation in international law to protect the ecological integrity of transboundary watercourses. The thesis specifically examines the obligation to protect environmental flows, which essentially means to protect a certain water flow for the benefit of freshwater ecosystems and the ecosystem services they supply. The obligation to protect the integrity of transboundary wat
This PhD thesis deals with the sub-cycle nature of ultrafast phenomena that occur in strong-field light–matter interactions. As it is of interest to control these phenomena, we must understand them in order to manipulate them. The tools at our disposal are intense laser pulses of short duration, and the systems we study are atoms. A host of exotic phenomena may occur in strong-field light–matter i
We have recently discovered that the ZZ zinc finger domain represents a novel small ubiquitin-like modifier (SUMO) binding motif. In this study we identify the binding epitopes in the ZZ domain of CBP (CREB-binding protein) and SUMO1 using NMR spectroscopy. The binding site on SUMO1 represents a unique epitope for SUMO interaction spatially opposite to that observed for canonical SUMO interaction
Multi-objective performance assessment of operational strategies at wastewater treatment plants (WWTPs) is a challenging task. The holistic perspective applied to evaluation of modern WWTPs, including not only effluent quality but also resource efficiency and recovery, global environmental impact and operational cost calls for assessment methods including both on- and off-site effects. In this stu
Despite 3 decades of basic and clinical studies, there is still no dopaminergic cell therapy for Parkinson's disease. Several arguments have been put forward why this approach, so far tested with transplantation of human fetal mesencephalic dopamine-rich tissue, will never be of clinical use and should be abandoned: (1) Lack of efficacy in 2 sham surgery-controlled trials; (2) occurrence of troubl
In this essay, I discuss two major theoretical discourses of modernity, namely, of classical modernity and postmodernity. Moreover, I aim at a proposition of a possible historical relation between those two discourses of crucial importance to modernity’s intellectual history. This historical connection is founded on what I call the principle of insufficient reason. The principle of insufficient
Several recent international publications (e.g. Platzack 1996, 2001; Håkansson, Pienemann & Sayehli 2002; Pienemann 1998; Pienemann & Håkansson 1999) have claimed that learners take the same developmental route in the acquisition of syntax of a second or foreign language, irrespective of their first language (L1). Targetlike verb placement in a Germanic V2 language like German, Dutch or Sw
A myoelectric control system for prostheses was developed and evaluated on six healthy subjects. These were able to control a computer-animated hand in real-time with a 20 Hz update rate. A data glove, equipped with joint angle sensors, was used to train the system and to evaluate the continuous predictions of joint angles. A linear envelop filter was used for EMG signal pre-processing and the rec
Guaranteeing reliable access to water and clean energy has been one of the most debated topics to promote sustainable development, which has made the Water–Energy Nexus (WEN) a relevant field of study. However, despite much development of the WEN, there are still many gaps to be addressed. One of these gaps is the understanding of temporal features. To address this, this study aimed to identify, c
Research on tourism enclaves has relied mainly on topographical understandings of the phenomenon. The focus has been on the ontic, that which is or exists instead of the relational qualities or properties of tourism enclaves. Topographical conceptions thus tend to simplify enclavic processes and attributes that are much more complex than meets the eye. In this article, we make the case for topolog
The main purpose of this thesis is to present a Cultural-Historical Activity Theory (CHAT) based analysis of the activities conducted by and with visually impaired users supported by audio-haptic technology.This thesis covers several studies conducted in two projects. The studies evaluate the use of audio-haptic technologies to support and/or mediate the activities of people with visual impairment
The 2030 Agenda of the United Nations comprises 17 Sustainable Development Goals (SDGs) and 169 sub-targets which serve as a global reference point for the transition to sustainability. The agenda acknowledges that different issues such as poverty, hunger, health, education, gender equality, environmental degradation, among others, are intertwined and can therefore only be addressed together. Impl
Mitochondria are central organelles in the homeostasis of the cardiovascular system via the integration of several physiological processes, such as ATP generation via oxidative phosphorylation, synthesis/exchange of metabolites, calcium sequestration, reactive oxygen species (ROS) production/buffering and control of cellular survival/death. Mitochondrial impairment has been widely recognized as a
Heavy road freight transports in Sweden are responsible for a significant portion of national greenhouse gas emissions. Earlier research has looked at the purchasing process of transports in a business-to-business context and established its importance for limiting environmental impact. This thesis’ purpose is to study purchasing criteria related to the climate and explore the potential use of emi
Lake sediments have lately been explored as a 10Be archive, complementing previous research on ice cores and marine sediments. 10Be is an important proxy as it can be used to study past solar activity, a factor which affects the climate. Where other methods studying solar activity only cover a brief period of history, 10Be has the potential to go further back in time. The concentrations of 10Be st
Klimatförändringen medför att allt mer frekventa och kraftiga skyfall belastar den ständigt växande staden. Urbaniseringen tillsammans med förtätningen av stadsmiljöer har lett till att sådana regn får allt större konsekvenser. Detta beror på den ökade andelen hårdgjorda ytor som hindrar nederbörd från att naturligt infiltrera. Istället bildas större volymer ytavrinning som måste ledas bort för atDue to climate change more extreme precipitation is expected to strike the constantly growing cities around the world. Urbanization along with densification of urban areas magnifies the impact of heavy rainfall. These two processes have increased the amount of hard surfaces that prevent precipitation to naturally infiltrate, and therefore result in larger amount of surface runoff that must be dive
The use of sludge as fertilizers contributes to the recycling of nutrients to the environment due to its origin from wastewater and therefore relatively high content of nutrients and organic matter. However, wastewater does also contain hazardous compounds like heavy metals and micropollutants which eventually are separated to the sludge during the treatment processes at the wastewater treatment p
