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Small synthetic ligands for protein purification have become increasingly interesting with the growing need for cheap chromatographic materials for protein purification and especially for the purification of monoclonal antibodies (mAbs). Today, Protein A-based chromatographic resins are the most commonly used capture step in mAb down stream processing; however, the use of Protein A chromatography
Supply chain management includes coordination and motivation of independently operating partners. Therefore, it is important to align logistics structures, processes and incentives, especially when making major changes involving those components. Traditionally, cost, quality, and service have served as prioritized performance indicators for supply chains, but lately risk is also taken into conside
The Yiddish language is over 1,000 years old and incorporates German, Slavic, and Hebrew elements. The prevalent view claims Yiddish has a German origin, whereas the opposing view posits a Slavic origin with strong Iranian and weak Turkic substrata. One of the major difficulties in deciding between these hypotheses is the unknown geographical origin of Yiddish speaking Ashkenazic Jews (AJs). An an
It has previously been shown that sera from multiparous women have increased levels of anti-idiotypic antibodies specific for anti-HLA molecules. γ-Globulins prepared from these sera may be superior to commercial preparations of intravenous γ-globulin (IVIg) for inhibiting HLA alloimmunization. To test this, F(ab′)2 fragments prepared from either commercial IVIg or from the sera of men or multipar
Eftersom innovation ger konkurrensfördelar, ökar marknadsandelar och påskyndar den övergripande institutionella tillväxten, utgör innovation en erkänd framgångsfaktor för organisationer. Under det senaste decenniet har ett paradigmskifte från traditionella innovationsstudier, med fokus på forskning och utveckling, till medarbetardriven innovation (EDI) skett. Då den senaste litteraturkartläggningeInnovation is widely recognized as a critical factor of organizational success as it cultivates competitive edge, augments market share, and accelerates overall institutional growth. During the last decade, a paradigm shift from the traditional innovation studies, focusing on research and development (R&D), toward employee-driven innovation (EDI) has been observed. However, the last literature
This thesis attempts to show tangible ways in which commodification of experience expands into areas outside of direct commercial activity, in contemporary mind and society. The user reviews of Google Maps (URGM) regarding places that don't offer sales of goods and services are being studied empirically, through qualitative text analysis. Functional analysis is also used to study the functions
Den här uppsatsen syftar till att ur ett rättsutvecklingsperspektiv redogöra för och diskutera framväxten av det internationella brottet folkmord (genocide). Raphael Lemkin myntade 1944 begreppet genocide. Han hade då också en genomtänkt definition av vad begreppet behövde innebära för att omfatta de illdåd som utförs i världen. Bakgrunden till hans engagemang grundade sig i det turkiskottomanska
Antimicrobial peptides (AMPs) are evolutionarily ancient molecules. They are essential innate immune response molecules that protect organisms from invading pathogens. Tissue factor pathway inhibitors (TFPI-1 and TFPI-2) C-terminal derived peptides exert host defense mechanisms against microbes. Studies showed that in human plasma, C-terminal TFPI-1 and -2 derived peptides mediate bacterial killin
Kärnvapen är i allra högsta grad kraftfulla militära och politiska vapen. På grund av detta är frågan om dess legalitet i internationell rätt sedan länge omdebatterad. När frågan ställdes inför den internationella domstolen myntades ett nytt begrepp; ”statlig överlevnad”. Domstolens användning av begreppet väckte frågan om statlig överlevnad utgör ett exceptionellt undantag som kan rättfärdiga vå
Introduction: Recent haemophilia treatment advances include new recombinant FVIII (rFVIII) products with improved pharmacokinetic (PK) properties that aim to reduce the burden of prophylaxis. These treatments are commonly referred to as extended half-life rFVIII products (EHL rFVIII). There is no uniform definition of what constitutes an EHL rFVIII. Such a definition would help physicians, patient
Tissue factor pathway inhibitor-2 (TFPI-2) has previously been characterized as an endogenous anticoagulant. TFPI-2 is expressed in the vast majority of cells, mainly secreted into the extracellular matrix. Recently we reported that EDC34, a C-terminal peptide derived from TFPI-2, exerts a broad antimicrobial activity. In the present study, we describe a previously unknown antimicrobial mode of ac
