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Kaposi's sarcoma-associated herpes virus (KSHV) encodes a complement inhibitor named KSHV complement control protein (KCP). We have previously shown that KCP inhibits the human complement system by disrupting the C3 convertase of complement. KCP can accelerate the decay of the classical C3 convertase and it can act as a cofactor for factor I (R), which then cleaves and inactivates C4b or C3b (in t

The Kenyan central rift has witnessed dramatic climatic changes over relatively short periods of time in response to global climatic changes, with the water levels of the lakes within the rift rising and falling with these changing conditions. There is considerable evidence showing extreme wet and dry phases throughout their existence. These wet and dry phases also influenced the vegetation cover,

I snart 500 år har människan använt sig av diverse optiska instrument för att betrakta sådant som inte är möjligt att se med blotta ögat. Teleskop har använts för att studera himlakroppar och mikroskop för att exempelvis undersöka små biologiska beståndsdelar. Det finns idag många olika metoder inom optisk mikroskopi men samtliga följer en liknande grundprincip. Objektet som ska avbildas exponerasSeveral significant pathogenic bacteria exhibit surface proteins that bind human antibodies, preventing them from being recognized by the human immune system. These bacteria are thus protected from elimination and can survive in the host organism. One common such bacteria is the Streptococcus pyogenes that exhibits the antibody binding M protein on its surface. Streptococcus pyogenes causes more t

Kan cellers proteiner bota HPV- sjukdomar? Livmoderhalscancer är en av de vanligaste cancersjukdomarna som drabbar kvinnor världen över. Varje år, diagnostiseras ungefär 500 000 kvinnor och 270 000 dör i sjukdomen, varav de flesta dödsfallen sker i utvecklingsländer. Livmoderhalscancer orsakas av det vanligt förekommande viruset humant papillomvirus (HPV) och för att hitta bättre behandling mot sHuman papillomaviruses (HPVs) are small DNA viruses that have evolved over millions of years and are well-adapted to humans. Persistent infections with HPVs, can result in cancer development. There are over 200 different HPV types that can be divided into high- and low risk types based on their ability to cause cancer. HPV16 is the most common high- risk type that accounts for more than 50 % of al

Populärvetenskaplig sammanfattning: Mer än två miljarder människor, mestadels i utvecklingsländer, saknar tillgång till moderna energikällor eller elektricitet. Behovet av rena, effektiva, pålitliga och ekonomiskt överkomliga energitjänster är en viktig fråga i utvecklingsländer, särskilt för landsbygden, där merparten av befolkningen bor. Förnyelsebara energikällor i form av småskaliga vattenkrafOver 2 billion people, mostly in developing countries, have no access to modern fuels or electricity. The necessity of clean, efficient, reliable and affordable energy services is a crucial issue in developing countries, especially in the context of rural areas where the majority of the people lives. Renewable energy sources in shape of small-scale hydropower systems are a complement or alternativ

hEP4-R (human prostaglandin E2 receptor, subtype EP4) is a Gs-linked heterotrimeric GPCR (G-protein-coupled receptor). It undergoes agonist-induced desensitization and internalization that depend on the presence of its C-terminal domain. Desensitization and internalization of GPCRs are often linked to agonist-induced b-arrestin complex formation, which is stabilized by phosphorylation. Subsequentl