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Dihydropicrotoxinin binding sites in mammalian brain : Interaction with convulsant and depressant benzodiazepines

The specific binding of [3H]α-dihydropicrotoxinin to rat brain membranes was inhibited competitively and potently (IC50 ≅ 100 nM) by a convulsant benzodiazepine drug, RO5-3663. This compound did not inhibit high affinity flunitrazepam binding to the same tissue under similar conditions, and its reported pharmacological activity as an antagonist of GABAergic synaptic transmission, which resembles t

Barbiturate receptor sites are coupled to benzodiazepine receptors

Picrotoxin and convulsant binding sites in mammalian brain

Improved prediction of site-rates from structure with averaging across homologs

The microbial biodiversity at the archeological site of Tel Megiddo (Israel)

Risk of childhood asthma is associated with CpG-site polymorphisms, regional DNA methylation and mRNA levels at the GSDMB/ORMDL3 locus

Single-nucleotide polymorphisms (SNPs) in GSDMB (Gasdermin B) and ORMDL3 (ORMDL sphingolipid biosynthesis regulator 3) are strongly associated with childhood asthma, but the molecular alterations contributing to disease remain unknown. We investigated the effects of asthma-associated SNPs on DNA methylation and mRNA levels of GSDMB and ORMDL3. Genetic association between GSDMB/ORMDL3 and physician

Adsorption sites in O and CO coadsorption phases on Rh(111) investigated by high-resolution core-level photoemission

Coverage- and temperature-dependent site occupancy of carbon monoxide on Rh(111) studied by high-resolution core-level photoemission

Adsorption sites in coadsorption systems determined by photoemission spectroscopy : K and CO coadsorbed on Rh(111)

On the adsorption sites for CO on the Rh(111) single crystal surface

Multi-site interactions : Understanding the offsite impacts of land use change on the use and supply of ecosystem services

Cs₃Cu₄In₂Cl₁₃ Nanocrystals : A Perovskite-Related Structure with Inorganic Clusters at A Sites

An effort to synthesize the Cu(I) variant of a lead-free double perovskite isostructural with Cs2AgInCl6 resulted in the formation of Cs3Cu4In2Cl13 nanocrystals with an unusual structure, as revealed by single-nanocrystal three-dimensional electron diffraction. These nanocrystals adopt a A2BX6 structure (K2PtCl6 type, termed vacancy ordered perovskite) with tetrahedrally coordinated Cu(I) ions. In

Ion and Site Correlations of Charge Regulating Surfaces : A Simple and Accurate Theory

Charge regulation is fundamental in most chemical, geochemical, and biochemical systems. Various mineral surfaces and proteins are well-known to change their charge state as a function of the activity of the hydronium ions, that is, the pH. Besides being modulated by the pH, the charge state is sensitive to salt concentration and composition due to screening and ion correlations. Given the importa

DOSIMETRY AND CANCER RISK ESTIMATIONS FOR DIFFERENT RADIATION PROTECTION SOLUTIONS AT DECOMMISSIONING A CONTAMINATED NUCLEAR POWER PLANT SITE

Accurate prediction of substitution rates at protein sites with a mutation-selection model

Modeling atmospheric CO2 concentration profiles and fluxes above sloping terrain at a boreal site

A European aerosol phenomenology -4 : Harmonized concentrations of carbonaceous aerosol at 10 regional background sites across Europe

Although particulate organic and elemental carbon (OC and EC) are important constituents of the suspended atmospheric particulate matter (PM), measurements of OC and EC are much less common and more uncertain than measurements of e.g. the ionic components of PM. In the framework of atmospheric research infrastructures supported by the European Union, actions have been undertaken to determine and m

Preserved leukocyte CD11b expression at the site of interstitial inflammation in patients with high-flux hemodiafiltration

A regional perspective on present and future soil chemistry at 16 Swedish forest sites

Protein Kinase Cepsilon Actin-binding Site Is Important for Neurite Outgrowth during Neuronal Differentiation.

We have previously shown that protein kinase Cepsilon (PKCepsilon) induces neurite outgrowth via its regulatory domain and independently of its kinase activity. This study aimed at identifying mechanisms regulating PKCepsilon-mediated neurite induction. We show an increased association of PKCepsilon to the cytoskeleton during neuronal differentiation. Furthermore, neurite induction by overexpressi