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Tec family protein tyrosine kinases (TFKs) play a central role in hematopoietic cellular signaling. Initial activation takes place through specific tyrosine phosphorylation situated in the activation loop. Further activation occurs within the SH3 domain via a transphosphorylation mechanism, which for Bruton's tyrosine kinase (Btk) affects tyrosine 223. We found that TFKs phosphorylate preferential
The crystal structures of three conformations, T6, T3R3 and R6, of bovine insulin were solved at 1.40, 1.30 and 1.80 angstrom resolution, respectively. All conformations crystallized in space group R3. In contrast to the T6 and T3R3 structures, different conformations of the N-terminal B-chain residue PheB1 were observed in the R6 insulin structure, resulting in an eightfold doubling of the unit-c
The Na(+), K(+)-adenosine triphosphatase (ATPase) maintains the electrochemical gradients of Na(+) and K(+) across the plasma membrane--a prerequisite for electrical excitability and secondary transport. Hitherto, structural information has been limited to K(+)-bound or ouabain-blocked forms. We present the crystal structure of a Na(+)-bound Na(+), K(+)-ATPase as determined at 4.3 Å resolution. Co
Denna studie ämnar att öka förståelsen för hur den alternativa mediesajten Avpixlat strategiskt kommunicerar sin bild av det svenska samhället, hur denna uppfattas av sajtens läsare och vilka implikationer det kan få för demokratin. I ett dialek- tiskt förhållningssätt undersöks kommunikationen utifrån såväl sändar- som läsarperspektiv, med hjälp av retoriska- och receptionsanalytiska metoder. Stu
Bathing in natural and artificial bodies of water has been an integral part of human history. Establishments dedicated to bathing has served as cultural cornerstones, important religious sanctuaries and social arena, providing relaxation, hygiene and strengthening communities when running water and indoor plumbing wasn’t accessible. Even if these places are in decline due to commercialization of b
“Between the tracks” builds upon the concept of reclaiming a brownfield. It explores what can happen when industrial activity vacates valuable land in the city center. Through urban recycling, the project unlocks the value of an underutilized railyard and reimagines the last, such a large, and free area in the center of Gdynia in Poland. In 1926, when the first plan of Gdynia was created, the mai
A globally growing population, an increased energy consumption and growing environmental awareness have made the interest for renewable energy sources, such as wind power, higher. As a result of the increased demand the need for new and improved technologies have increased. The energy production of a wind turbine is highly affected by the rotor blade length, which is limited by the massive dead lo
Drought and heat events, such as the 2018 European drought, interact with the exchange of energy between the land surface and the atmosphere, potentially affecting albedo, sensible and latent heat fluxes, as well as CO 2 exchange. Each of these quantities may aggravate or mitigate the drought, heat, their side effects on productivity, water scarcity and global warming. We used measurements of 56 e
The power systems of drilling rigs have changed considerably since the early days of steam driven machinery. This paper reviews that progression, from mechanical and diesel electric configurations through to modern hybrid and renewable integrated systems, with a focus on the power conversion technologies that enable each stage. Coverage includes the electrical architecture of drilling rig power sy
The percentages of Type I muscle fibres were measured systematically in ATPase-stained, transverse cryostat sections of whole tibialis cranialis muscles from 8 young, adult beagles. The distance of the section from the origin of the muscle does not significantly affect the mean percentage. There are no identifiable differences in mean percentages between right and left muscles. Differences in mean
