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The engineered CD80 variant fusion therapeutic davoceticept combines checkpoint antagonism with conditional CD28 costimulation for anti-tumor immunity

Despite the recent clinical success of T cell checkpoint inhibition targeting the CTLA-4 and PD-1 pathways, many patients either fail to achieve objective responses or they develop resistance to therapy. In some cases, poor responses to checkpoint blockade have been linked to suboptimal CD28 costimulation and the inability to generate and maintain a productive adaptive anti-tumor immune response.

C:/Report_050125/REPORT.dvi

C:/Report_050125/REPORT.dvi Department of Mechanical Engineering Solid Mechanics ISRN LUTFD2/TFHF–05/5111–SE(1–156) EVALUATING THE 3DM MODEL - AN EXPERIMENTAL AND FINITE ELEMENT STUDY Master’s Dissertation by Oscar Elison and Lars Hansson Supervisors Johan Tryding, Tetra Pak Magnus Just, Tetra Pak Anders Harrysson, Div. of Solid Mechanics Matti Ristinmaa, Div. of Solid Mechanics Copyright c© 2005

https://www.solid.lth.se/fileadmin/hallfasthetslara/utbildning/examensarbete/TFHF5111.pdf - 2026-05-30

The Comparative and Combined Effects of Nitric Oxide and Higher Alkanes in Sensitizing Methane Oxidation

The comparative and combined effects of nitric oxide (NO) and higher alkanes on methane oxidation were examined by experimentation and kinetic modeling. Experiments were conducted using fuel-lean, lower-alkanes mixtures with NO (0-400 ppm v/v) in an atmospheric flow reactor at residence time of 2 s over the temperature range of 820-950 K. NO was found to greatly promote methane conversion, and its

Comparing Chemical Reaction Mechanisms for Jet Fuel in Turbulent Premixed Combustion Simulations

The compositions of alternative jet fuels can vary radically, and the consequences of these differences are a subject of ongoing investigation. Numerical combustion simulations are vital to this research and require chemical reaction mechanisms that efficiently and accurately capture the chemical pathways of combustion. Here, we present the recently developed Z79 collection of small pathway-centri

Experimental and numerical study of ground vortex interaction in an air-intake

The airflow field around air-intake related geometries has been investigated experimentally and numerically. The configuration of the experimental set-up is used to model a jet engine running near the ground. The experiments have been carried out using both PIV and LDA techniques in order to obtain the mean and fluctuating velocity field as well as the low speed frequencies related to the system o

Ledarskap i försvaret - en fenomenologisk undersökning av KB-elevers perspektiv före och efter en strapatsvecka

We have conducted a phenomenological study on students who will become officers (KB-elever) and our subject is leadership. Our first purpose was to determine their point of view in leadership and how the describe it on two occasions. One occasion before and one after a field-training course in survival techniques. We also wanted to see if the view on leadership was shared and if it had changed aft

Lunds universitet i världsklass

Lunds universitet i världsklass Hamburg June 4-5 2009 Workshop on Critical Period(s) and successive acquisition in childhood Cliticisation in the Acquisition of Child French L2: a Cross-Learner Comparison Jonas Granfeldt Lund University jonas.granfeldt@rom.lu.se Hamburg June 4-5 2009 Workshop on Critical Period(s) and successive acquisition in childhood Outline INTRODUCTION The project Hypothesis

https://projekt.ht.lu.se/fileadmin/user_upload/sol/ovrigt/projekt_sprakutv_franska/Granfeldt_cliticisation_publish.ppt - 2026-05-30

Syllabi and reading lists Autumn 2025

Autumn Semester 2025 Semester 1All specialisationsSMMX11 Introduction to Service Management (7.5 credits) 1/9 – 30/9-25SyllabusReading listExaminerFor specialisation Culture and Creativity ManagementSMMV12 Introduction to Culture and Creativity Management (7.5 credits) 1/10 – 31/10-25SyllabusReading listExaminerFor specialisation Retailing and ConsumptionSMMM13 Introduction to Retailing and Consum

https://www.ses.lu.se/en/education/study-information/syllabi-and-reading-lists/syllabi-and-reading-lists-autumn-2025 - 2026-05-29

Intrahost evolution of the HIV-2 capsid correlates with progression to AIDS

HIV-2 infection will progress to AIDS in most patients without treatment, albeit at approximately half the rate of HIV-1 infection. HIV-2 capsid (p26) amino acid polymorphisms are associated with lower viral loads and enhanced processing of T cell epitopes, which may lead to protective Gag-specific T cell responses common in slower progressors. Lower virus evolutionary rates, and positive selectio

Alveolar mast cells shift to an FcεRI-expressing phenotype in mild atopic asthma: a novel feature in allergic asthma pathology.

Background: A unique feature of alveolar mast cells is their low high-affinity IgE receptor (FcεRI) expression. Recent discoveries in uncontrolled asthma suggest that the appearance of FcεRI-expressing alveolar mast cells may be a novel disease-specific feature of allergic asthma. This study investigates whether increased FcεRI-expressing alveolar mast cells are present in patients with mild aller

Effects of Safety Measures for Pedestrians and Cyclists at Crossing Facilities on Arterial Roads

The principal aims of this thesis are to define suitable measures for safer pedestrian and cycle crossings on arterial roads, to implement these measures on a large scale and to acquire an insight into their effects on road users' safety, experiences, mobility and the environment, by creating a 30 km/h milieu at the above crossings. Two characteristically different types of measures, physical meas

Clinical studies of extended-half-life recombinant FVIII products for prophylaxis in adults and children : A critical review from the physician's perspective

This review compares the methodology of published clinical studies investigating the extended-half-life (EHL) factor VIII (FVIII) products, rFVIIIFc (efmoroctocog alfa, Elocta®/Eloctate®), BAY 94-9027 (damoctocog alfa pegol, Jivi®), BAX 855 (rurioctocog alfa pegol, Adynovate®) and N8-GP (turoctocog alfa pegol, Esperoct®) including the phase 2/3 studies, A-LONG (NCT01181128), PROTECT VIII (NCT01580

LUCSUS seminars

Principally on Thursdays, 11.00-12.00 CET, at LUCSUS Join our research seminar with LUCSUS researchers and invited guests presenting their latest research. Autumn programme 2025The programme is updated continuously. January 22Too hot, too cold: dwelling in discomfort as a question of thermal justice11-12 in MaathaiSpeaker: Alice Guilbert, doctoral researcher and assistant at the Institute of Envir

https://www.lucsus.lu.se/seminars - 2026-05-29