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Microorganisms have unique biochemical mechanisms to inhibit the growth or kill other microorganisms in the same environment. Bacterial threat agents (BTA) are more effective than conventional weapons because of these characteristics, therefore, the development and production of biological weapons are still relevant. Early warning signals need to be obtained for fast and accurate detection of BTA
Pool boiling is an effective heat dissipation approach in electronic cooling, battery thermal management, etc. This study used the electrochemical deposition method to fabricate one smooth nickel specimen (named Ni-smooth) and three specimens with a porous nickel-stacked structure. The three porous specimens were created with deposition current densities of 0.5 A·cm–2 (named Ni-0.5), 2.0 A·cm–2 (n
AIMS: Cellular communication network factor 2 (CCN2) is a matricellular protein implicated in fibrotic diseases, with ongoing clinical trials evaluating anti-CCN2-based therapies. By uncovering CCN2 as abundantly expressed in non-diseased artery tissue, this study aimed to investigate the hypothesis that CCN2 plays a pivotal role in maintaining smooth muscle cell (SMC) phenotype and protection aga
BACKGROUND: Complement activation may promote atherosclerosis. Yet, data on the to which extent complement, and more specifically the alternative complement pathway, is activated in patients with carotid atherosclerosis and related to adverse outcome in these patients, are scarce.METHODS AND RESULTS: We measured, by ELISA, plasma levels of factor D, properdin, C3bBbP (C3 convertase), and factor H
Invertebrate embryos have relatively low fossilization potential; however, when preserved, they can offer crucial insights into the evolutionary developmental biology of extinct animals. Here we report new exceptionally preserved fossil embryos from the early Fortunian (early Cambrian) of China, which are assigned to two new taxa, Saccus xixiangensis gen. et sp. nov. and Saccus necopinus gen. et s
OBJECTIVE: This study evaluated the effects of a 6-week osteoarthritis (OA) exercise and education intervention on metabolic health markers, including blood pressure (BP), glycated haemoglobin (HbA1c), high-density lipoprotein (HDL), cholesterol levels and weight in individuals with both OA and diabetes.METHODS: Data originated from the Swedish Osteoarthritis and Diabetes cohort, which is composed
This thesis offers a cultural analysis of climate change, modernisation and sustainable development in the pastoral landscape of Baringo, Northern Kenya. For the majority of the pastoralists living there, life is defined by crippling poverty, ethnic violence and an increasingly erratic and unpredictable climate. In response, a growing number of people have moved away from the traditional reliance
The impact of islet neuronal nitric oxide synthase (nNOS) on glucose-stimulated insulin secretion (GSIS) is less understood. We investigated this issue by performing simultaneous measurements of the activity of nNOS versus inducible NOS (iNOS) in GSIS using isolated murine islets. Additionally, the significance of extracellular NO on GSIS was studied. Islets incubated at basal glucose showed modes
Landscape-scale land use is important in driving species communities and interactions. However, despite increasing concerns regarding the ecological consequences of insect declines, our understanding of how the relative proportions of different land cover types influence insect herbivory in species-rich semi-natural habitats remains limited. This study assessed leaf, stem, and flower herbivory acr
High latitude mires are key ecosystems in the context of climate change since they store large amounts of carbon while constituting an important natural source of methane (CH4). However, while a growing number of studies have investigated methane fluxes (FCH4) at the plot- (~1 m2) and ecosystem-scale (~0.1–0.5 km2) across the boreal biome, variations of FCH4 magnitudes and drivers at the mesoscale
BACKGROUND: Mental health service users often experience difficulties interpreting and regulating sensory stimuli resulting in increased anxiety, decreased abilities to engage in activities and a hampered recovery process. However, there are limited studies on the implementation of such recovery-oriented interventions targeting sensory difficulties via sensory modulation techniques. Therefore, the
Methylenetetrahydrofolate dehydrogenase/cyclohydrolase (MTHFD2) is a new drug target that is expressed in cancer cells but not in normal adult cells, which provides an Achilles heel to selectively kill cancer cells. Despite the availability of crystal structures of MTHFD2 in the inhibitor- and cofactor-bound forms, key information is missing due to technical limitations, including (a) the location
Objective: Immediate cartilage structural alterations in the acute phase after an anterior cruciate ligament (ACL) rupture may be a precursor to posttraumatic osteoarthritis (PTOA) development. Our aim was to describe changes in cartilage matrix in the subacute phase of the acutely ACL-injured knee compared to the contralateral uninjured knee. Design: Participants (n = 118) aged 15–40 years with a
Gestational diabetes mellitus (GDM) is associated with increased risk of pregnancy complications and adverse perinatal outcomes. GDM often reoccurs and is associated with increased risk of subsequent diagnosis of type 2 diabetes (T2D). To improve our understanding of the aetiological factors and molecular processes driving the occurrence of GDM, including the extent to which these overlap with T2D
The interaction of protein S with membranes and subsequent combination with complement C4b-binding protein (C4BP) was studied. Protein S interacted with phospholipid vesicles in a calcium-dependent manner typical of other vitamin K-dependent proteins. Association of C4BP with protein S showed no apparent selectivity for membrane-bound or solution phase protein S. When bound to the membrane, the pr
Introduction: Primary health care centers (PHCCs) in Sweden are struggling to maintain a balance between increasing demands of service and supervision and learning activities for a growing number of students. We sought a deeper understanding of primary care physicians and managers behavioral intention towards supervising, and their perceptions of the structural preconditions and support needed.Met
Summary: This narrative review describes efforts to improve the care and prevention of fragility fractures in New Zealand from 2012 to 2022. This includes development of clinical standards and registries to benchmark provision of care, and public awareness campaigns to promote a life-course approach to bone health. Purpose: This review describes the development and implementation of a systematic a
För frisk för Försäkringskassan men för sjuk för att jobba Tidiga rehabiliteringsinsatser för en hållbar återgång i ordinarie arbete efter psykisk ohälsa För frisk för Försäkringskassan men för sjuk för att jobba Tidiga rehabiliteringsinsatser för en hållbar återgång i ordinarie arbete efter psykisk ohälsa Thomas Andrén © Saco 2021 www.saco.se 3 Försäkringskassans fokus på omställning försvårar ti
Objective To investigate the relationship between active commuting and atherosclerosis in middle age using state-of-the-art coronary CT angiography (CCTA). Methods This cross-sectional study used data from the Swedish CArdioPulmonary bioImage Study (SCAPIS) and included 23 722 randomly recruited individuals aged 50–64 years from six different regions in Sweden. The exposure was commuting mode, ass
