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The field of phylogenomics has emerged during the last five years, as the number of fully or partially sequenced genomes has increased rapidly. Using whole genomes for phylogenetic studies greatly increases the accuracy of the trees determined, and can potentially resolve phylogenetic questions that could not be resolved bu studies using only a few gene sequences. In the current thesis selected
Recent reports suggested frequent occurrence of cancer associated somatic mutations within regulatory elements of the genome. Based on initial exome sequencing of 21 melanomas, we report frequent somatic mutations in skin cancers in a bidirectional promoter of diphthamide biosynthesis 3 (DPH3) and oxidoreductase NAD-binding domain containing 1 (OXNAD1) genes. The UV-signature mutations occurred at
The neutron beam at the Studsvik facility for boron neutron capture therapy (BNCT) and the validation of the related computational model developed for the MCNP-4B Monte Carlo code are presented. Several measurements performed at the epithermal neutron port used for clinical trials have been made in order to validate the Monte Carlo computational model. The good general agreement between the MCNP c
Agricultural intensification has contributed substantially to the increase in food production, but has come at the expense of soil degradation and environmental problems. Management of soil based ecosystem services need to be considered in agricultural management since intensive management implies not only costs to the farmer but also to society. In this study we used data from four long-term (55
We analyzed 37 primary invasive carcinomas for BRCA1 and BRCA2 mutations by screening the entire coding regions of both genes. Seven predicted truncating mutations (four in BRCA1 and three in BRCA2) and one novel BRCA1 missense variant (S1542C) were identified (8/37, 22%). Two of the BRCA1 mutations were somatic changes, whereas the remaining three BRCA1 changes and all mutations of BRCA2 were fou
A Saccharomyces cerevisiae screening strain was designed by combining multiple genetic modifications known to improve xylose utilization with the primary objective of enhancing xylose growth and fermentation in xylose isomerase (XI)-expressing strains. Strain TMB 3045 was obtained by expressing the XI gene from Thermus thermophilus in a strain in which the GRE3 gene coding for aldose reductase was
Syftet är att studera och analysera processer vars mål är att förändra vardagen för två marginaliserade grupper, så att de i större utsträckning blir delaktiga i samhället. De två undersökta grupperna är manliga unga narkomaner och äldre utvecklingsstörda. Avhandlingen består av tre geografiska perspektiv: 1) det tidsgeografiska synsättet, 2) känslan för platsen och 3) socialgeografiska teorier omThe aim is to study and analyse processes intended to change the daily lives of two marginalised groups and enable them to participate to a greater extent in the community. The two marginalised groups are young male drug addicts and older intellectually disabled. The thesis is permeated by three geographic perspectives: 1) the time-geographic approach, 2) sense of place and 3) social-geographic th
Purpose EURAMOS-1, an international randomized controlled trial, investigated maintenance therapy with pegylated interferon alfa-2b (IFN-α-2b) in patients whose osteosarcoma showed good histologic response (good response) to induction chemotherapy. Patients and Methods At diagnosis, patients age ≤ 40 years with resectable high-grade osteosarcoma were registered. Eligibility after surgery for good
Advances in next-generation RNA-sequencing have revealed the complexity of transcriptomes by allowing both coding and noncoding (nc) RNAs to be analyzed. However, limited data exist regarding the whole transcriptional landscape of chronic lymphocytic leukemia (CLL). In this pilot-study, we evaluated RNA-sequencing in CLL by comparing two subsets which carry almost identical or `` stereotyped'' B-c
Background Gadolinium (Gd) neutron capture therapy (GdNCT) is based on a neutron capture reaction (NCR) that involves emission of both short and long range products. The aim of this study was to investigate both the microscopic and macroscopic contributions of the absorbed dose involved in GdNCT. Methods Cylindrical containers with diameters 1-30 mm filled with a solution of Gd were irradiated wit
BACKGROUND: The time from symptom onset to reperfusion in acute myocardial infarction (MI) has been shown to be a poor predictor of patient outcome. Acute electrocardiographic (ECG) changes, however, have been shown useful for estimated acuteness of myocardial ischemia using the Anderson-Wilkins ECG ischemia acuteness score (AW-acuteness score). The aim was to study whether acute ischemic ECG chan
Dark matter accounts for about 85% of all matter in the Universe, yet its particle nature remains unknown. The Light Dark Matter eXperiment (LDMX) is a proposed fixed-target missing-momentum experiment that intends to probe the predominantly experimentally uncharted MeV-GeV mass range for "light dark matter". A significant challenge for LDMX is to efficiently veto rare photo-nuclear back
This study examines the burgeoning patterns of the phenomenon of new-build gentrification. This phenomenon reflects a social justice imbalance, where affluence takes precedence over equitable access and the interests of economically vulnerable groups, in shaping urban spaces. While economic and environmental sustainability have been prioritized in urbanization goals, the social dimensions, includi
In the context of the COVID-19 pandemic, this thesis focuses on the bottom-up conceptualisation of the notion of rule of law, developed by a group of activists against a COVID vaccine passport enforced in Italy (so-called Green Pass), and their subsequent everyday acts of resistance. By using a multimodal digital ethnography methodology, centred on both in-person and digital informal encounters, t
The aim of the study has been to examine how young men describe training habits, eating habits and good health. In order to achieve this, six qualitive semistructured interviews were held with six men between the age of 20-30 who are practising or have been practising some sort of exercise. The interview contained questions regarding training habits, eating habits and view of good health, but also
In the summer of 2021 a massive rainfall caused floods in Gävleborg län. The flood contributed to high burden on SOS-alarm and the fire and rescue service when approximately 700 emergency calls were received in a short amount of time. The flood caused floodings in cellars, damage to infrastructure and problems moving through traffic. The high burden caused the inner commanding officer of the fire
Detta examensarbete är en fallstudie av Tumaini Open School för gravida studenter och studerande mödrar i Tabora, Tanzania. Genom den ideella organisationen Ingenjörer utan gränser Sverige genomförde författarna en Minor Field Study i Tanzania för att fastställa efterfrågade eltjänster, det resulterande elbehovet och den maximala dagliga effektkurvan för skolan vid fullskalig verksamhet. Vidare prThis master thesis is a case study of Tumaini Open School for pregnant and mothering students located in Tabora, Tanzania. Through the volunteer organisation Engineers Without Borders Sweden, the authors conducted a Minor Field Study to Tanzania in order to determine the requested electricity services, resulting electricity demand and maximum daily load profile for the school at full-scale operati
Global investment decisions are increasingly prioritizing sustainability, and this study examines how firm-level practices toward sustainability have the potential to attract foreign ownership. Focusing on the Eastern European and Central Asian (EECA) region, the interaction between foreign direct investment (FDI) and sustainable management practices within the context of middle- to upper-middle-i
In this paper we study structure from motion problems for parallel cylinders. Using sparse keypoint correspondences is an efficient (and standard) way to solve the structure from motion problem. However, point features are sometimes unavailable and they can be unstable over time and viewing conditions. Instead, we propose a framework based on silhouettes of quadric surfaces, with special emphasis
Utvärdering RALS2025 (ver 260312) Sida 1 (11) Saco-S-föreningen vid Linnéuniversitetet Saco-S utvärdering av RALS 2025 Under år 2025 genomfördes för nionde gången lönesättande samtal som generellt tillvägagångs- sätt för samtliga medlemmar anslutna till ett fackförbund inom Saco-S vid Linnéuniversitetet. Som grund för lönesättningsprocessen låg en överenskommelse som gällde RALS 2025, vilken under
