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We have evaluated capacitive and thermal transducers for recognition of bio- molecular interactions with different analytes. These assays were made in flow analysis systems because of the simplicity such methods provide. A capacitive transducer, based on a surface modified gold electrode, has the ability to monitor affinity based interactions directly, provided that the interactions introduce mea
Understanding the factors that drive geographic variation in life history is an important challenge in evolutionary ecology. Here, we analyze what predicts geographic variation in life-history traits of the common lizard, Zootoca vivipara, which has the globally largest distribution range of all terrestrial reptile species. Variation in body size was predicted by differences in the length of activ
The interface between living cells and artificial surfaces are highly relevant for biomedical applications such as implants and organized cell growth for tissue reconstruction as well as for basic science purposes. In the present thesis, we have studied axonal guidance on various nano-patterned surfaces such as polymethyl-meth-acrylate, porous silicon and on magnetically aligned Ni nanowires. Furt
Popular Abstract in Swedish Kvinnomisshandel är ett ärende som skiljer sig från andra polisärenden genom att det beskrivs som svårt att hantera. Polismän säger sig vilja agera men på grund av olika svårigheter - organisation, lagstiftning, de inblandades inställning - är man förhindrad att ingripa. I Vilja med förhinder låter Magnus Lundberg polismännen komma till tals. Genom åskådliggörande exempPolice officers often talk about wife abuse as a practical problem in their work situation. This problem is often used to explain why the officers do not file a complaint when they have reason to believe that a woman has been abused, something they are obliged to do according to Swedish law. One may approach these explanations as reflections of “reality”, as expressions of complicated work conditi
Shrines and Souls provides a multi-layered contextualization of the article on religious liberty in the Universal Declaration of Human Rights (Article 18), which was propounded by the United Nations General Assembly on December 10, 1948. It shows how the framers of the Declaration decided to break with some of the conventional ways of framing religious liberty in international law, by foregroundin
Following stroke, complete cellular death in the ischemic brain area may ensue, with remaining brain areas undergoing tissue remodelling to various degrees. Experience-dependent brain plasticity exerted through an enriched environment (EE) promotes remodelling after central nervous system injury, such as stroke. Post-stroke tissue reorganization is modulated by growth inhibitory molecules differen
We describe a series of microcalorimeter X-ray spectrometers designed for a broad suite of measurement applications. The chief advantage of this type of spectrometer is that it can be orders of magnitude more efficient at collecting X-rays than more traditional high-resolution spectrometers that rely on wavelength-dispersive techniques. This advantage is most useful in applications that are tradit
Background: Epilepsy patients commonly exercise less than the general population. Animal studies indicate beneficial effects of physical activity in established epilepsy, while its effect on the development is currently less known. Methods: Here, we investigated the incidence of epilepsy during 20 years in a cohort of participants from the long-distance Swedish cross-country ski race Vasaloppet (n
A novel type of limited double-moment scheme for bulk microphysics is presented here for cloud-systemresolving models (CSRMs). It predicts the average size of cloud droplets and crystals, which is important for representing the radiative impact of clouds on the climate system. In this new scheme, there are interactive components for ice nuclei (IN) and cloud condensation nuclei (CCN). For cloud ic
Background: Patients diagnosed with metastatic breast cancer have poor outcome with a median survival of approximately 2 years. While novel therapeutic options are urgently needed, the great majority of breast cancer research has focused on the primary tumor and less is known about metastatic breast cancer and the prognostic impact of the metastatic tumor microenvironment. Here we investigate the
Marginalised agrarian societies are suggested to be the most vulnerable to environmental hazards and other perturbations. There are competing explanations for this phenomenon, which include: a lack of development, global environmental change, and the development process itself, or capitalism more specifically. All three causal arguments are compelling, but typically offer only partial explanations
Male breast cancer (BCa) is a rare disease accounting for less than 1% of all breast cancers and 1% of all cancers in males. The clinical management is largely extrapolated from female BCa. Several multigene assays are increasingly used to guide clinical treatment decisions in female BCa, however, there are limited data on the utility of these tests in male BCa. Here we present the gene expression
In everyday life, we bind visual samples of the world into a coherent episodic memory via eye movements. Previous eye tracking research revealed that visual scrutiny, gaze transitions between event elements, and refixations during encoding predict successful memory formation. However, little is known about the neural mechanisms of these processes. Here, we combine EEG and eye tracking to investiga
Atmospheric heavy elements have been observed in more than a quarter of white dwarfs (WDs) at different cooling ages, indicating ongoing accretion of asteroidal material, whilst only a few per cent of the WDs possess a dust disc, and all these WDs are accreting metals. Here, assuming that a rubble-pile asteroid is scattered inside a WD's Roche lobe by a planet, we study its tidal disruption and th
OBJECTIVE: Children and adolescents with obsessive-compulsive disorder (OCD) are at risk for long-term adversity, but factors influencing long-term outcomes are unclear. A general factor of psychopathology, often referred to as the p factor, captures variance shared by all mental disorders and has predicted long-term outcomes in youth with anxiety and depressive disorders. The p factor has never b
As part of the project FIRE21, a workshop was organised in Trondheim on September 8, 2023, inviting all project partners (Lund University, Research Institutes of Sweden, the Technical University of Denmark and the Norwegian University of Science and Technology) to brainstorm on potential problems for the fire and rescue services (FRS) in the 21st century, and recommendations on how to improve the
Inhalation therapy treating severe infectious disease is among the more complex and emerging topics in controlled drug release. Micron-sized carriers are needed to deposit drugs into the lower airways, while nano-sized carriers are of preference for cell targeting. Here, we present a novel and versatile strategy using micron-sized spherical particles with an excellent aerodynamic profile that diss
Background: The molecular pathways linking short and long sleep duration with incident diabetes mellitus (iDM) and incident coronary heart disease (iCHD) are not known. We aimed to identify circulating protein patterns associated with sleep duration and test their impact on incident cardiometabolic disease. Methods: We assessed sleep duration and measured 78 plasma proteins among 3336 participants
Epilepsy is a severe neurological disease manifested by spontaneous recurrent seizures due to abnormal hyper-synchronization of neuronal activity. Epilepsy affects about 1% of the population and up to 40% of patients experience seizures that are resistant to currently available drugs, thus highlighting an urgent need for novel treatments. In this regard, anti-inflammatory drugs emerged as potentia
