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Aggregated α-synuclein (α-syn) is the main constituent of Lewy bodies, which are a pathological hallmark of Parkinson’s disease (PD). Environmental factors are thought to be potential triggers capable of initiating the aggregation of the otherwise monomeric α-syn. Braak’s seminal work redirected attention to the intestine and recent reports of dysbiosis have highlighted the potential causative rol
Anion exchange membranes (AEMs) functionalized with certain alicyclic quaternary ammonium cations show high alkaline stability, which is necessary for use in fuel cells and water electrolyzers. Here, we have prepared and studied a series of poly(fluorene alkylene)s incorporating N,N-dimethylpiperidinium (DMP) and 6-azoniaspiro[5.5]undecane (ASU) cations in spirocyclic and bis-spirocyclic arrangeme
BackgroundKetamine has emerged as a fast-acting and powerful antidepressant, but no head to head trial has been performed, Here, ketamine is compared with electroconvulsive therapy (ECT), the most effective therapy for depression.MethodsHospitalized patients with unipolar depression were randomized (1:1) to thrice-weekly racemic ketamine (0.5 mg/kg) infusions or ECT in a parallel, open-label, non-
Global climate change is projected to intensify soil drying-rewetting (DRW) events with extended drought, especially in arid and semiarid ecosystems. However, the extent to which the soil DRW with intensified drought can alter soil respiration (Rs) in forests is still under debate, and subsequent legacy effects on Rs are not well understood. Here, we conducted a 180-d soil incubation experiment to
10Be in ice cores has been instrumental for reconstructing past changes in solar activity prior to direct observations. For a robust use of these records, it is pivotal to understand the 10Be transport and deposition. However, there are only few high-resolution seasonal 10Be data longer than one full solar cycle (11 years) that could enable a quantification of the influences of atmospheric circula
Mental illness in adults such as depression, anxiety or bipolar disorder are nowadays a significant public health problem. Many of those with mental illness are parents of underage children. A parents’ mental illness affects children’s development and wellbeing, but this association is mediated by parental skills and the relation between child and parent. In summary, at a group level there is an i
Quantum annealing is a promising approach for obtaining good approximate solutions to difficult optimization problems. Folding a protein sequence into its minimum-energy structure represents such a problem. For testing new algorithms and technologies for this task, the minimal lattice-based [hydrophobic (H) or polar (P) beads] HP model is well suited, as it represents a considerable challenge desp
Various mechanisms of secondary ice production (SIP) cause multiplication of numbers of ice particle, after the onset of primary ice. A measure of SIP is the ice enhancement ratio (“IE ratio”) defined here as the ratio between number concentrations of total ice (excluding homogeneously nucleated ice) and active ice-nucleating particles (INPs). A convective line observed on 11 May 2011 over the Sou
West Nile virus (WNV), a mosquito-borne zoonosis, has emerged as a disease of public health concern in Europe. Recent outbreaks have been attributed to suitable climatic conditions for its vectors favoring transmission. However, to date, projections of the risk for WNV expansion under climate change scenarios is lacking. Here, we estimate the WNV-outbreaks risk for a set of climate change and soci
Remediation of soil contaminated with cadmium (Cd) and lead (Pb) is critical for tobacco production. Silicon (Si) fertilizer can relieve heavy metal stress and promote plant growth, however, it remains unknown whether fertilization with Si can mitigate the effects of Cd and Pb on tobacco growth and alter microbial community composition in polluted soils. Here we assessed the effect of two organic
Electroconvulsive therapy (ECT) is effective and safe for adults with severe depression, but less studied in adolescents. Here, we examined the indications, prevalence, practice, response and remission rates, and side effects in young people treated with ECT in Sweden. We also examined the usage of ECT in the transition to adult psychiatry. Using data from national patient registers and the Swedis
Objective(s): Nitrite, a nitric oxide (NO) donor, increases insulin secretion from pancreatic islets and has positive metabolic effects in type 2 diabetes (T2D). Here, we test the hypothesis of whether nitrite-induced insulin secretion is due to blunting of diabetes-induced oxidative stress in the islets. Materials and Methods: T2D was created in male rats using a combination of streptozotocin at
Qualitative measurements of both OH and polycyclic aromatic hydrocarbons (PAH) as well as quantitative data of soot volume fraction f(v) have been obtained in vaporized liquid fuels, with the main goal of providing experimental data for combustion models and numerical mechanism validation. Measurements were carried out in a laminar coflow burner which was designed, built and integrated with an eva
The work presented here is based on two papers, both pertaining to perturbation-based control strategies in industrial fed-batch fermentation processes. The first paper describes a new control strategy for avoiding overflow metabolism in the exponential growth phase of a fermentation, based on analysis of the frequency spectrum of the dissolved oxygen measurement following a periodic perturbation
Induced pluripotent stem cells (iPSCs) generated from somatic cells of patients can be used to model different human diseases. They may also serve as sources of transplantable cells that can be used in novel cell therapies. Here, we analyzed neuronal properties of an iPSC line derived from a patient with a juvenile form of Huntington's disease (HD) carrying 72 CAG repeats (HD-iPSC). Although its i
The major histocompatibility complex (MHC) is a membrane protein group of central importance in the immune system. It is divided into two main classes, class I and class II. The MHCs are highly polymorphic which is believed to be indication of trans-species polymorphism (TSP). There is TSP when an allele is maintained in two species through a speciation event. The songbirds that I study here belon
Cell-based therapies are emerging as new promising treatments in stroke. However, their functional mechanism and therapeutic potential during early infarct maturation has so far received little attention. Here, we asked if cell-based delivery of the interleukin-1 receptor antagonist (IL-1Ra), a known neuroprotectant in stroke, can promote neuroprotection, by modulating the detrimental inflammatory
In 21 century, with the trend of globalization, both large and small organizations are facing an environment characterized by extremely high level of competition. In order to be competitive, China's managers are endeavouring to try every effort to improve employees' performance within sound organizational culture, thus to improve organizations' competence. Yet as a matter of fact, sinc
The aim of this paper is to study the extent to which non-Annex I countries are implementing or exploring select actions that support both climate change mitigation and sustainable development objectives in the energy sector. The research is based on a survey of the national communications of 100 non-Annex I Parties to the UNFCCC. Although national communications are intended to provide informatio
