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Popular Abstract in Swedish Transplantation av dopaminceller från mänskliga foster kan förbättra funktionen hos patienter med Parkinsons sjukdom (Lindvall 1997, Björklund 2000a). Man har kunnat visa att transplantaten har återställt dopaminproduktionen i striatum till normala nivåer i flera fall, och till 70-80% av normalt i majoriteten av de patienter som transplanterats i Lund. Transplantaten haTransplantation of embryonic human neural tissue can restore function in patients with Parkinson’s disease, but there is a severe shortage of donor tissue which limits the applicability of the technique. Embryonic neural tissue from other species, xenogeneic tissue, would provide a readily accessible donor tissue with the potential to help patients if the immunological reactions in the host could

Disposal behaviour represent the last phase in the consumption cycle. From an environmental point of view it is extremely important to know the factors behind individual behaviour in waste handling. There are several aspects of interest, for example willingness of waste separation and re-use of products. The aim of this article is to analyse the importance of environmental concern, disposal behavi

Objective: To update evidence for available therapies in the treatment of hip and knee osteoarthritis (OA) and to examine whether research evidence has changed from 31 January 2006 to 31 January 2009. Methods: A systematic literature search was undertaken using MEDLINE, EMBASE, CINAHL, AMED, Science Citation Index and the Cochrane Library. The quality of studies was assessed. Effect sizes (ESs) an

Importance: The association between long sleep duration and mortality appears stronger in East Asian populations than in North American or European populations. Objectives: To assess the sex-specific association between sleep duration and all-cause and major-cause mortality in a pooled longitudinal cohort and to stratify the association by age and body mass index. Design, Setting, and Participants

Importance: Clonal hematopoiesis of indeterminate potential (CHIP) may contribute to the risk of atrial fibrillation (AF) through its association with inflammation and cardiac remodeling. Objective: To determine whether CHIP was associated with AF, inflammatory and cardiac biomarkers, and cardiac structural changes. Design, Setting, and Participants: This was a population-based, prospective cohort

Background: Voluntary self-exclusion from gambling is a common but underdeveloped harm reduction tool in the management of gambling problems or gambling disorders. Large-scale, multi-operator, and operator-independent self-exclusion services are needed. A recent nationwide multi-operator self-exclusion service in Sweden (Spelpaus), involving both land- and web-based gambling sites, is promising, b

Background: In Alzheimer’s disease (AD), the associations between tau pathology and brain atrophy and cognitive decline are well established, but imperfect. We investigate whether cerebrospinal fluid (CSF) biomarkers of biological processes (vascular, synaptic, and axonal integrity, neuroinflammation, neurotrophic factors) explain the disconnection between tau pathology and brain atrophy (brain re

Background: Up-to-date estimates of stroke burden and attributable risks and their trends at global, regional, and national levels are essential for evidence-based health care, prevention, and resource allocation planning. We aimed to provide such estimates for the period 1990–2021. Methods: We estimated incidence, prevalence, death, and disability-adjusted life-year (DALY) counts and age-standard

Den tekniska utvecklingen har ändrat hur människor kommunicerar med och om varandra. Den har också fört med sig nya former av övergrepp, däribland så kallade bildbaserade sexuella övergrepp. Begreppet bildbaserade sexuella övergrepp innefattar alla former av framställande och/eller spridande av privata, sexuella bilder utan samtycke från den avbildade. Exempel på sådana övergrepp är ”hämndporr”, sTechnological developments have changed the way people communicate with and about each other. It has also brought with it new forms of abuse, including so-called image-based sexual abuse. Image-based sexual abuse includes all forms of creation and / or distribution of private, sexual images without the consent of the person depicted. Examples of such abuse is “revenge porn”, stealth photography, u

Cancer kan drabba vem som helst och kan ha sitt ursprung i många olika områden i kroppen. Antalet nya cancerfall ökar varje år, men vissa typer av cancer har bättre prognos än andra. Den vanligaste cancertypen i Sverige är prostatacancer och den drabbar framför allt äldre män. Prostatacancer har god prognos och det finns effektiva metoder att helt bota prostat- acancer om den behandlas i ett tidigPurpose: Recent developments in external radiotherapy and its utilization with artificial in- telligence (AI) enables advanced treatment plans for a range of different disease sites. By adapting to the anatomy of the day, target coverage can be ensured while sparing more healthy tissue. The purpose of this project was to study the feasibility and benefits of daily cone beam computed tomography (CB

The unnecessary and disproportionate use of pre-trial detention is a global issue that affects developed and developing countries alike. According to World Prison Brief, Cambodia has ranked 12th (among 217 countries) making it become a country with one of the highest percentages of pre-trial detainees: 71.8 percent to be exact. The excessive and unnecessary use of pre-trial detention in the Kingdo

Abstract The significance of terrestrially derived iron (Fe) for marine ecosystems and its implications on other biogeochemical cycles is well recognised. It has been recently highlighted that the concentration of Fe in several Swedish rivers has increased strongly over the last 40 years. Four rivers draining into the Baltic Sea were used in the present study in order to assess the aggregation pr

Sexualbrotten i svensk rätt kräver idag att gärningsmannen har använt någon typ av våld eller hot, eller har utnyttjat ett hjälplöst tillstånd. År 2003 kom emellertid Europadomstolens avgörande i Bulgariendomen, i vilken kan utläsas att varje sexuell handling som begås utan samtycke ska vara straffbar. Sedan dess har det i Sverige livligt debatterats om huruvida domen innebär att den svenska lagenThe sexual offences in Swedish law of today require that the perpetrator has used violence or threats, or that he has exploited a helpless state. However, in 2003 the European Court of Human Rights delivered a judgment in the case of M.C v. Bulgaria, which stated that any non-consensual sexual act must be punishable. There has been a legal discussion in Sweden ever since, regarding whether this ju

Kostnadsansvar för motpartens rättegångskostnader i domstolsprocess är normalt förekommande i processrätten, men saknas i förvaltningsprocessen. Historiskt sett betraktades kostnadsansvaret som ett skadestånd, en ordning som sedermera övergavs i merparten av processformer, dock inte i förvaltningsprocessen där synen på kostnadsansvaret som skadestånd ständigt finner sin renässans. Denna uppsats unLiability for reimbursing the other party's costs in court proceedings is a common aspect of procedural law, yet it is notably absent in administrative proceedings. Historically, such cost liability was viewed as a form of tort, a perspective that has since been largely abandoned in most types of litigation. However, this tort-based view of cost liability persists and is experiencing a constan

In Sweden, climate projections indicate longer growing seasons with more frequent extreme weather events, such as droughts and heavy rainfall, posing significant challenges to existing crop systems. Simultaneously, the sector is under growing pressure to reduce its environmental footprint, especially in response to agricultural nutrients runoff contributing to the eutrophication of the Baltic Sea.

There is an urgent need for accurate and validated methods to measure plasma phosphorylated tau (p-Tau) biomarkers in Alzheimer’s disease (AD). In this study, we compared the performance of new commercially available plasma p-Tau217 assay developed by ALZpath to other established p-Tau assays in an autopsy-confirmed sample. We included 72 participants from the Arizona Study of Aging and Neurodegen

Before performing 177Lu-DOTATATE therapy for neuroendocrine tumors, somatostatin receptor (SSTR) PET imaging is currently used to confirm sufficient tumor SSTR expression, but it also has potential to be used to personalize treatment by predicting absorbed doses to critical organs. This study aims to validate the predictive capability of SSTR PET in anticipating renal absorbed dose in the first cy

Evidence from neuropathological cohorts indicates that a CSF α-synuclein (α-syn) seed amplification assay (SAA) might provide quantitative kinetic parameters correlating with α-syn pathology burden in patients with Lewy body disease (LBD). Studies are needed to assess their longitudinal trend during the presymptomatic and clinical disease phases and their correlation with measures of disease progr

Importance: Traditional adoption studies examine disorder-to-disorder parent-offspring transmission. The role of parental genetic risk in offspring disorder transmission can capture indirect genetic effects from parental genotype to parental phenotype to offspring risk. Objective: To assess the relative importance of genetic and rearing effects from paternal family genetic risk scores (FGRSs) in 3