Filtyp
When Jean-Francois Mayet was elected mayor of the French city of Châteauroux in 2001, he inherited a mass transit system that was functional but under-used by residents. The city, located about halfway between Paris and Bordeaux, had collective aims that were similar to other medium-sized cities in Europe: to reduce the city’s ecological footprint while improving the local economy and fostering a
Recently, many genome-wide profiling studies provided insights into the molecular make-up of major cancer types. The deeper understanding of these genetic alterations and their functional consequences led to the discovery of novel therapeutic opportunities improving clinical management of cancer patients. While tissue-based molecular patient stratification is the gold standard for precision medici
BACKGROUND AND PURPOSE: A new concept to increase return to work for patients listed as sick with chronic musculoskeletal pain has been used at a rehabilitation centre in Luleå, Sweden. The programme includes work for three days a week and intensive rehabilitation for two days a week, for 12 weeks, as a combination of 'on the job' training and rehabilitation after a period off work sick. The rehab
In large software organizations with a product line development approach a selective testing of product variants is necessary in order to keep pace with the decreased development time for new products, enabled by the systematic reuse. The close relationship between products in product line indicates an option to reduce the testing effort due to redundancy. In many cases test selection is performed
Neutrophil extracellular traps (NETs) are structures that neutrophils form in response to various stimuli, including invading pathogens. NETs are increasingly studied, and their importance has been demonstrated in autoimmunity and infection. However, no consensus has emerged on their quantification, with many studies resorting to manually counting NETs in microscopy images. NETQUANT is a free soft
Glycerol-3-phosphate dehydrogenase is a biomedically important enzyme that plays a crucial role in lipid biosynthesis. It is activated by a ligand-gated conformational change that is necessary for the enzyme to reach a catalytically competent conformation capable of efficient transition-state stabilization. While the human form (hlGPDH) has been the subject of extensive structural and biochemical
Shear forces affect self-assembly processes ranging from crystallization to fiber formation. Here, the effect of mild agitation on amyloid fibril formation was explored for four peptides and investigated in detail for Aβ42, which is associated with Alzheimer's disease. To gain mechanistic insights into the effect of mild agitation, nonseeded and seeded aggregation reactions were set up at various
Background/Aim: The Kingdom of Cristal, an area in southern Sweden, is historically heavily burdened by heavy metals. Cadmium, lead, mercury and arsenic have previously been used in glass production and large amounts of glass crust have been deposited around the Kingdom of Cristal and used as filling material for the construction of new residential areas, parks and schools. The purpose of the proj
The evolution of suppressed recombination between sex chromosomes is widely hypothesized to be driven by sexually antagonistic selection (SA), where tighter linkage between the sex-determining gene(s) and nearby SA loci is favored when it couples male-beneficial alleles to the proto-Y chromosome, and female-beneficial alleles to the proto-X. Although difficult to test empirically, the SA selection
The human brain can be described as a complex network of functional connections between distinct regions, referred to as the brain functional network. Recent studies show that the functional network is a dynamic process and its community structure evolves with time during continuous task performance. Consequently, it is important for the understanding of the human brain to develop dynamic communit
Paracetamol/acetaminophen (N-acetyl-p-aminophenol, APAP) is a top selling analgesic used in more than 600 prescription and non-prescription pharmaceuticals. To study efficiently some of the potential undesirable effects associated with increasing APAP consumption (e.g., developmental disorders, drug-induced liver injury), there is a need to improve current APAP biomonitoring methods that are limit
Human activities in coastal areas have accelerated during the last 200 years. Environmental changes resulting in a combination of three threats, i.e., deoxygenation, warming, and ocean acidification, impact particularly sub-polar regions. To better understand these environmental challenges, we need to develop tools to compare our present situation with previous periods less impacted by anthropogen
INTRODUCTION: Informal carers in paid employment-working carers (WKCs)-have complex support needs. However, little is known about WKCs' pattern of informal care provision, the support they receive, the impact providing care has on their employment, and how these vary between male and female WKCs. This study describes the pattern of informal care provision and received support among Swedish WKCs.RE
Free electron lasers or FELs, have transformed the way science has been done in the last decades by providing coherent, highly brilliant radiation at wavelengths not achievable with conventional lasers. Their most important characteristic, along side brightness, is their coherence, which allows users to perform experiments that rely on precise phase characteristics of the probing radiation.The FEL
The purpose of this study is to address the main reasons that limit Jordanian women from undertaking expatriation, based on the assumption that Arab women’s opportunities for international engagement may be compromised by local cultural and institutional issues. Design/methodology/approach: A cross-sectoral survey with 60 Jordanian expatriates (30 women and 20 men) located in EU countries and the
Several articles in the Recalling Fieldwork collection discuss the role of state surveillance and how it affected our ethnographic fieldwork. This was certainly the case in my own research in Romania in the decade from 1974-1985, where my secret police (Securitate) file ended up being over 600 pages long, and where I was blacklisted in 1985 due to hostile activities. Other ethnographers had simila
Ternary III-V nanowires are commonly grown using the Au-seeded vapor-liquid-solid method, wherein the solid nanowires are grown from nanoscale liquid seed particles, which are supplied with growth species from the surrounding vapor phase. A result of the small size of these seed particles is that their composition can vary significantly during the cyclical layer-by-layer growth, despite experienci
The importance to cut costs and to be as efficient as possible has never been as important as it is today in order to stay competitive in the market. IKEA are currently facing increasing challenges with the production growth due to a high demand from the market and goals for 2020. This large growth will affect the bottom line of the supply chain, the suppliers. The necessary production growth also
The aim of this study was to explore how healthcare counselors in their role as child representatives at adult habilitation clinics in Sweden experience the implementation of support for children as next of kin. Healthcare law in Sweden states that children as next of kin are entitled to information, advice and support by healthcare professionals when living together with an adult relative that ha
