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Preeclampsia (PE) is a serious pregnancy complication that manifests as hypertension and proteinuria after the 20(th) gestation week. Previously, fetal hemoglobin (HbF) has been identified as a plausible causative factor. Cell-free Hb and its degradation products are known to cause oxidative stress and tissue damage, typical of the PE placenta. A1M (α1-microglobulin) is an endogenous scavenger of
In recent years, nanostructure technology involving Ill-V semiconductors have made significant progress in areas such as optoelectronics and spintronics. A number of new materials and nanostructures have been invented, most of them being of a very dilute character or extremely small. Because of these properties, their structural characterization on an atomic scale is of profound importance. One im
This thesis discusses modeling and implementation of reconfigurable hardware architectures for real-time applications. The target application in this work is digital holographic imaging, where visible images are to be reconstructed based on holographic recordings. The reconstruction process is computationally demanding and requires hardware acceleration to achieve real-time performance. Thus, this
Nanowires were grown by means of a novel aerosol-based method called Aerotaxy. Here an aerosol of Au catalyst nanoparticles in N-2 is mixed with MOVPE precursors in a flow-through reactor at atmospheric pressure, whereby nanowires are produced continuously in high concentrations. We demonstrate the possibility of in situ doping of the NWs and the realization of well-controlled p-type GaAs nanowire
Ion channels and ion fluxes control many aspects of tissue homeostasis. During oncogenic transformation, critical ion channel functions may be perturbed but conserved tumor specific ion fluxes remain to be defined. Here we used the tumoricidal protein-lipid complex HAMLET as a probe to identify ion fluxes involved in tumor cell death. We show that HAMLET activates a non-selective cation current, w
The subject of the thesis is the psychê, a Greek word whose closest equivalent is the Swedish “själ”, the English “soul”, the French “âme” and the German “Seele”. The meanings of these words are far from being the same. What is more, the Greek psychê has shifting meanings, both synchronically and diachronically speaking. We are faced with two problems: What does the word psychê designate and how i
Metastatic disease is responsible for most cancer deaths, and hematogenous spread through circulating tumor cells (CTC) is a prerequisite for tumor dissemination. CTCs may undergo epithelial–mesenchymal transition where many epithelial cell characteristics are lost. Therefore, CTC isolation systems relying on epithelial cell markers are at risk of losing important subpopulations of cells. Here, a
Lipid nanoparticles of reversed internal phase structures, such as cubic micellar (I2) structure show good drug loading ability of peptides and proteins as well as some small molecules. Due to their controllable small size and inner morphology, such nanoparticles are suitable for drug delivery using several different administration routes, including intravenous, intramuscular and subcutaneous inje
The recognition of carbohydrates by proteins is a fundamental aspect of communication within and between living cells. Understanding the molecular basis of carbohydrate-protein interactions is a prerequisite for the rational design of synthetic ligands. Here we report the high- to ultrahigh-resolution crystal structures of the carbohydrate recognition domain of galectin-3 (Gal3C) in the ligand-fre
Studies aimed at the identification of biomarkers and treatment targets of cancer have focused on mRNAs, miRNAs, and proteins expressed by malignant cells, while glycoproteins mainly produced by stromal cells remain relatively unexplored. Glycans lack a given template for their biosynthesis that involves the concerted action of several, sometimes >15 different enzymes. This fact complicates the an
The excessive generation and accumulation of 40- and 42-aa β-amyloid peptides (Aβ40/Aβ42) in selectively vulnerable brain regions is a major neuropathological feature of Alzheimer's disease. Aβ, derived by proteolytic cleavage from the β-amyloid precursor protein (βAPP), is normally secreted. However, recent evidence suggests that significant levels of Aβ also may remain inside cells. Here, we hav
Protein dynamics on the micro- to millisecond time scale is increasingly found to be critical for biological function, as demonstrated by numerous NMR relaxation dispersion studies. Methyl groups are excellent probes of protein interactions and dynamics because of their favorable NMR relaxation properties, which lead to sharp signals in the H-1 and C-13 NMR spectra. Out of the six different methyl
A SIFO-survey ordered by E.ON has shown that more than every fourth person in Sweden feels that they have poor knowledge and control over their energy use, and that four out of ten would like to be more aware and to have better control over it. A solution is to provide the householders with feedback of their energy consumption. Studies have shown that householders can reduce energy consumption wit
I have always been curious about the effects architecture and the built environment have on us. The special atmosphere and the ability to arouse a sense of safety and calmness, but also the negative feelings certain spaces can evoke. Which architectural elements contribute to the way we perceive a space and more importantly, does the built environment not only affect our emotions but also our ment
Syftet med uppsatsen är att redogöra för svensk rätt avseende ogiltighet av vilseledande avtal i förhållande till bluffakturor. Sedan tio år tillbaka har antalet polisanmälningar ökat markant rörande just bluffakturor, då finns det även ett stort mörkertal. Förutom att det drabbar många, är det betydande summor som årligen omsätts på grund av detta, således är detta ett ämne som förtjänar att belyThe purpose of this paper is to display Swedish law in regards to fake invoices and how these contracts under misleading agreements can be voided. The amount of police reports regarding fake invoices have increased significantly during the last ten years, one should also consider the big number of hidden statistics. Apart from the fact that it affects a lot of people it also has a high yearly turn
The increasing amount of renewable energy in the electrical grid comes with several challenges, of which overvoltage and congestion (overcurrents) are the subjects of this work. One flexible way of handling these problems is active management by some control system. There is a trade-off between simplicity when implementing the control system and the performance. In the project Active Network Manag
In the 21st century, wind power has emerged as a strong candidate in fulfilling societies goals of achieving carbon-free energy energy production. Windpower has evolved along with other technological developments, giving rise to larger turbines, but with the overall design trend remaining largely unchanged. Winfoor, a Swedish company based in Lund,aims to break that trend. With their new Triblade
Environments with a high number of systems that are dependent on each other create complexity in the testing of each system. For a test to perform correctly, every dependency has to be fully functional. If this condition is not met, the test will fail and measures need to be taken into the systems that are causing the problem before it can be repeated again. This is a problem that the test departm
