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Cyclins D1 and E play an important role in breast carcinogenesis. High cyclin E expression is common in hormone receptor negative and high grade aggressive breast cancer, whereas cyclin D1 in hormone receptor positive and low grade breast cancer. Experimental data has suggested that cyclin D1 and E mediate cell proliferation by different mechanisms in estrogen receptor (ER) positive and negative b

The majority of breast cancers express estrogen receptor α (ERα), and most patients with ERα-positive breast cancer benefit from antiestrogen therapy. The ERα-modulator tamoxifen and ERα-downregulator fulvestrant are commonly employed antiestrogens. Antiestrogen resistance remains a clinical challenge, with few effective treatments available for patients with antiestrogen-resistant breast cancer.

Transfusion-related acute lung injury (TRALI) remains a leading cause of transfusionrelated deaths. In most cases, anti-leukocyte antibodies in the transfusion product trigger TRALI, but not all anti-leukocyte antibodies cause TRALI. It has been shown that the anti-major histocompatibility complex (MHC) class I antibody 34-1-2S (anti-H-2Kd) causes TRALI in BALB/c mice (MHC class I haplotype H-2Kd)

Brevmall APPLICATION FOR ADMISSION TO POSTGRADUATE STUDIES AT THE FACULTY OF SCIENCE Subject for postgraduate studies ref no Personal details Last name, First name Personal reg. no. (yy-mm-dd-xxxx) Address Female Male Postal code, Town/City Telephone number E-mail address Citizenship Swedish Other (specify below) Former last name, if any Education Degree/courses at Lund University Higher education

https://www.science.lu.se/internal/sites/science.lu.se.internal/files/application_admission_postgraduate_studies.pdf - 2026-07-22

Studiens syfte var att undersöka hbtq+-personers upplevelser och hantering av minoritetsstress i nära relationer samt upplevda konsekvenser på hälsan och de nära relationerna. Detta gjordes genom semistrukturerade intervjuer med tio personer, som bröt mot cis- och/eller heteronormen. En tematisk analys av berättelserna utmynnade i tre huvudteman: Omvänd skuld- och ansvarsfördelning, Två sidor av mThe aim of this study was to explore how LGBTQ+ people experience and cope with minority stress in their close relationships, how minority stress affects the relationships and what health implications might come from it. Ten semi-structured interviews were conducted with LGBTQ+ individuals. A thematic analysis of the stories resulted in three main themes: Reverse guilt and liability, Two sides of

Background: Ocrelizumab is a humanized anti-CD20 antibody with increased antibody-dependent cellular cytotoxicity compared with rituximab. This phase I/II study evaluated its safety and efficacy in patients with relapsed/refractory follicular lymphoma (FL) after prior rituximab therapy. Design and methods: Forty-seven patients were treated in three dose cohorts and received eight infusions every 3

The joint actions of animals in partnerships or social groups evolve under both natural selection from the wider environment and social selection imposed by other members of the pair or group. We used experimental evolution to investigate how jointly expressed actions evolve upon exposure to a new environmental challenge. Our work focused on the evolution of carrion nest preparation by pairs of bu

Background: The accumulation of amyloid-β1−42 (Aβ1−42) peptides and phosphorylated-Tau181 (p-Tau181) tangles from the preclinical stages of Alzheimer’s disease (AD) has led to a biological definition of the disease. However, among Aβ1−42-positive individuals, cognitive decline onset varies, and some never develop symptoms. Genetic influences on molecular pathways and their interactions with protei

This thesis investigates how analyst coverage and blockholder ownership shape the informativeness of insider purchases in a market characterized by concentrated ownership, dispersed analyst coverage, and high retail participation. While prior research has established a negative relationship between analyst coverage and insider purchase abnormal returns in the U.S., whether this relationship genera

Purpose. Patients with fibromyalgia (FM) and chronic widespread pain (CWP) find physical activity troublesome. The purpose was to develop a questionnaire to investigate the experience of physical activity in FM and CWP populations. Method. A questionnaire was developed from a qualitative study. After that, a total of 204 patients with FM or CWP completed the questionnaire. A factor analysis was co

Two sets of ribosome structures have recently led to two different interpretations of what limits the accuracy of codon translation by transfer RNAs. In this review, inspired by this intermezzo at the Ribosome Club, we briefly discuss accuracy amplification by energy driven proofreading and its implementation in genetic code translation. We further discuss general ways by which the monitoring base