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Background and Purpose-We have previously shown that delivery of brain-derived neurotrophic factor (BDNF) through direct intrahippocampal gene transduction with a viral vector suppresses the formation of new dentate granule cells triggered by global forebrain ischemia. Here, we investigated whether inhibition of endogenous BDNF alters ischemia-induced neurogenesis in the dentate gyrus. Methods-Rat

Evaluating the trade interdependence among countries is the key to understanding critical metal minerals security. By constructing a novel interdependence network, this paper reveals a more comprehensive world hierarchy and risk system of critical metals, and focuses on the interdependencies between China and the US-led MSP countries before and after the Sino-US trade disputes. The results indicat

Bacterial infections represent a serious health care problem, and all multicellular organisms have developed defense mechanisms to eliminate pathogens that enter the host via different paths including wounds. Many invertebrates have an open circulatory system, and effective coagulation systems are in place to ensure fast and efficient closure of wounds. It was proposed early on that coagulation sy

Enzymes that affect glycoproteins of the human immune system, and thereby modulate defense responses, are abundant among bacterial pathogens. Two endoglycosidases from the human pathogen Streptococcus pyogenes, EndoS and EndoS2, have recently been shown to hydrolyze N-linked glycans of human IgG. However, detailed characterization and comparison of the hydrolyzing activities have not been performe

Pituitary adenohypophyseal tumors are considered as benign and termed “adenomas”. However, many tumors are invasive and a proportion of these exhibit an “aggressive behavior” with premature death due to progressive growth. Only very rare (0.2%) tumors with metastases are considered malignant and termed “carcinomas”. Taking into account this variability in behavior and the oncological definition, p

This chapter seeks to develop a theoretical basis for better understanding the intersections between public diplomacy (PD) and development communication (Devcom). It will be argued that both fields involve (1) theories of influence over social change in foreign countries; (2) a voluntary transfer of resources from an actor promoting a specific cause or agenda to a group or organization in a foreig

Increased use of powerful PCR technology for the routine detection of pathogens has focused attention on the need for international validation and preparation of official non-commercial guidelines. Bacteria of epidemiological importance should be the prime focus, although a "validation infrastructure" once established could easily be adapted for PCR-based detection of viruses and parasites. The ai

Adopting a qualitative approach to the investigation of high achievement, the authors analyzed how high-achieving women in the Swedish workplace made meaning of positive and negative experiences in their work. The data consisted of interviews with 15 women identified as being high achieving in their respective field, and it was analyzed using grounded theory methodology. The women described five d