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Shiga toxin-producing Escherichia coli O157:H7 is a virulent strain causing severe gastrointestinal infection, hemolytic uremic syndrome and death. To date there are no specific therapies to reduce progression of disease. Here we investigated the effect of pooled immunoglobulins (IgG) on the course of disease in a mouse model of intragastric E. coli O157:H7 inoculation. Intraperitoneal administrat
Group A streptococcus (GAS) is a highly adapted, human-specific pathogen that is known to manipulate the immune system through various mechanisms. GAS’ M protein constitutes a primary target of the immune system due to its spatial configuration and dominance on the bacterial surface. Antibody responses targeting the M protein have been shown to favor the conserved C region. Such antibodies (Abs) c
Delivery of antigenic peptides to antigen presenting cells (APCs) such as dendritic cells (DCs) using monoclonal antibodies (mAbs) is an attractive approach to evoke antigen-specific T cell activation and improve drug efficacy. Peptide linkage to mAbs has previously been achieved through genetic fusion, chemical conjugation, nano-engineered platforms and high affinity peptides. In this study, we h
Introduction: Subanesthetic doses of ketamine are a promising novel treatment for suicidality; however, the evidence for predictive biomarkers is sparse. Recently, measures of complexity, including Lempel–Ziv complexity (LZC) and multiscale entropy (MSE), have been implicated in ketamine's therapeutic action. We evaluated electroencephalogram (EEG)-derived LZC and MSE differences between responder
In the current work, cationic polymers functionalized with N-alicyclic quaternary ammonium (QA) cations were synthesized and characterized as potential hydroxide exchange membranes (HEMs) for application in fuel cells. Three different polymers, namely poly(arylene ether sulfone), spiro-ionene and poly(arylene alkylene), were explored as polymer backbones for the HEMs. Various mono- and spirocyclic
Pareto optimality is a concept that formalises the trade-off between a given set of mutually contradicting objectives. A solution is said to be Pareto optimal when it is not possible to improve one objective without deteriorating at least one of the other. A set of Pareto optimal solutions constitute the Pareto front. The Pareto concept applies well to the inverse planning process, which involves
Brevmall Postadress Paradisgatan 5 Telefon dir 046-222 91 21, växel 046-222 00 00, E-post Anita.Lennerstedt@psy.lu.se Internet http://www.psy.lu.se Ins t i tu t ionen för psykologi Ledningsgruppen för psyko logprogrammet Närvarande ledamöter Martin Wolgast Ordförande Inst för psykologi Kristian Almquist Studievägledare ”- Bengt Brattgård Lärarlag kurs 10 ”- Daiva Daukantaite Lärarlag kurs 12 ”- fr
https://www.psy.lu.se/sites/psy.lu.se/files/psp_161026_nr7_protokoll.pdf - 2026-07-22
Background. Anti-glomerular basement membrane (anti-GBM) disease often results in end-stage renal failure despite therapy with plasma exchange and immunosuppressive drugs. The newly discovered streptococcal enzymes IgG-degrading enzyme of S.pyogenes (IdeS) and endoglycosidase S (EndoS) act with remarkable specificity on circulating IgG. In this study, we investigate their ability in vivo to preven
The function of cultured mast cells may depend on genetic or environmental influence on the stem cell donor. This study investigates whether asthma or atopy in the donor influenced the growth and sensitivity of mast cells cultured from patients with asthma and healthy controls under identical conditions. Mast cells were cultured from peripheral blood from twelve patients with an objectively confir
In the study presented in this paper, the effect of different vehicle driving cycles on the pneumatic hybrid has been investigated. The pneumatic hybrid powertrain has been modeled in UT-Power and validated against experimental data. The GT-Power engine model has been linked with a MATLAB/simulink vehicle model. The engine in question is a single-cylinder Scania D12 diesel engine, which has been c
The West Link Project is a transport infrastructural investment in the expansion of public transport in the region Västra Götaland. The choice of transport infrastructure falls under the domain of the Swedish government, usually paid for by Swedish taxpayers. Therefore it is important to know if the choices made surrounding these investments are socio-economically profitable and whether or not the
Background: Women are less likely to receive oral anticoagulation or ablation for treatment of atrial fibrillation (AF). Identification of sex differences in arrhythmia characteristics and symptoms may lead to a better understanding of potential reasons for these differences. Objectives: To determine sex differences in AF with respect to heart rate, duration, burden, and symptoms in patients under
Vill du att din forskning ska nå ut till fler? Lund University Outreach Academy erbjuder utbildningar för dig som vill bli bättre på att kommunicera din forskning utanför akademin. Här får du konkreta verktyg och stöd för att nå ut till allmänhet, medier, beslutsfattare, finansiärer och samverkansparter. Utbildningarna som är en del av Lund University Outreach Academy är särskilt framtagna för for
Institutionen för handelsrätt Uppd: 2025-06-13 Tentamensschema september 2025 - januari 2026 Datum Kurskod Kursnamn Tid Lokal Fre 12 sep HURB05 HR-frågor i en ekonomisk kontext, dugga 8-10 MA9 Tors 25 sep HURB05 HR-frågor i en ekonomisk kontext, omdugga 8-10 EC2:169 Mån 29 sept HARH06 Arbetsrätten i metod och tillämpning 8-17 MA8 Tis 30 sept HARN50 Introduction to European and International Trade…
Institutionen för handelsrätt Uppd: 2025-06-17 Tentamensschema september 2025 - januari 2026 Datum Kurskod Kursnamn Tid Lokal Fre 12 sep HURB05 HR-frågor i en ekonomisk kontext, dugga 8-10 MA9 Tors 25 sep HURB05 HR-frågor i en ekonomisk kontext, omdugga 8-10 EC2:169 Mån 29 sept HARH06 Arbetsrätten i metod och tillämpning 8-17 MA8 Tis 30 sept HARN50 Introduction to European and International Trade…
Aim: Impaired regulation of glucose metabolism in childhood adversely affects bone health. We assessed the effect of fasting hyperglycemia and insulin resistance on bone turnover markers in prepubertal children with normal glycemia (<100 mg/dL) and fasting hyperglycemia (100-125 mg/dL). Methods: Glucose, hemoglobin A1c, IGF-I (insulin-like growth factor I), iP1NP (N-terminal propeptide of type I p
