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Randomized, double-blind, placebo-controlled phase III study of tasquinimod in men with metastatic castration-resistant prostate cancer

Purpose: Tasquinimod, a novel oral therapy targeting the tumor microenvironment, significantly improved progression-free survival (PFS) in a randomized, placebo-controlled phase II trial in men with metastatic castration-resistant prostate cancer (mCRPC). This phase III study was conducted to confirm the phase II results and to detect an overall survival (OS) benefit. Patients and Methods: Men wit

Modeling and Performance Analysis of Alternative Heat Exchangers for Heavy Vehicles

Cross flow heat exchangers made from aluminum are common as radiators in vehicles. However, due to the increasing power requirement and the limited available space in vehicles, it is extremely difficult to increase the size of heat exchangers (HEXs) placed in the front of vehicles. Placing the heat exchanger on the roof or at the underbody of vehicles might offer opportunity to increase the size o

COSM12 Literature 2023

Microsoft Word - CC8F33D3213AE7B825805BB0F2722EB2.docx COSM 12 Asian Studies: Political Systems, Governance, and Democratization in Asia 12 hp Course director: Paul O’Shea The required reading listed below accounts for 1045 pages. An additional 200 pages may be added according to the teachers’ instructions. Unless otherwise stated, all articles are available through the library website. All prices

https://www.ace.lu.se/sites/ace.lu.se/files/2023-05/COSM12_Literature_2023.pdf - 2026-05-28

COSM11 Literature 2023

Microsoft Word - 59BE73AA4D8F95C71714502247E9C167.doc Centre for East and South-East Asian Studies Course literature för CÖSM11, Asian Studies: The Economic Transformation of East and South East Asia, 12 ECTS. Second Cycle Total nr of pages: 1106 Asia Development Bank (2013)’Beyond Factory Asia, Fueling Growth in a Changing World’, ADB, Philippines, pp. 1- 40 [40 pages] Akter, Sonia, Rutsaert, Pie

https://www.ace.lu.se/sites/ace.lu.se/files/2023-05/COSM11_Literature_2023.pdf - 2026-05-28

Prognostic and treatment predictive significance of SATB1 and SATB2 expression in pancreatic and periampullary adenocarcinoma

Background: Pancreatic cancer and other pancreaticobiliary type periampullary adenocarcinomas have a dismal prognosis even after resection and neoadjuvant chemotherapy. Intestinal type periampullary adenocarcinomas generally have a better prognosis, but little is known on optimal neoadjuvant and adjuvant treatment. New prognostic and treatment predictive biomarkers are needed for improved treatmen

The functional variant of the CLC-Kb channel T481S is not associated with blood pressure or hypertension in Swedes.

Objective A common threonine481serine polymorphism (T481S) has been shown in vitro to strongly activate the chloride channel Kb (CLC-Kb) expressed in the kidney, and the 481S allele has been associated with human hypertension. The study aim was to evaluate the association of the T481 S polymorphism with blood pressure (BP) levels and the BP progression rate in Swedes. Design and methods The cardio

All-oral ixazomib, cyclophosphamide, and dexamethasone for transplant-ineligible patients with newly diagnosed multiple myeloma

Background: Novel efficacious treatments with long-term tolerability are needed for transplant-ineligible, newly diagnosed multiple myeloma (NDMM) patients. This phase 2 study evaluated the safety and efficacy of all-oral ixazomib-cyclophosphamide-dexamethasone (ICd) followed by single-agent ixazomib maintenance. Patients and methods: Patients were randomised (1:1) to receive 4.0 mg of ixazomib, 3

Lipid sponge phase nanostructures as carriers for enzymes

Nonlamellar lipid liquid crystalline phases have many potential applications, such as for drug delivery, protein encapsulation or crystallization. Lipid liquid crystalline sponge phase (L3) has so far not been very much considered in these applications, in spite of apparent advantages in terms of its flexibility and capacity of forming large aqueous pores able to encapsulate large bioactive molecu

Historia och nationalism : Sverigedemokraternas och Dansk Folkepartis historiska berättelser

This thesis studies the relationship between history and nationalism as expressed by the political parties the Sweden Democrats and the Danish People's Party. The study focuses on how the Sweden Democrats and the Danish People's Party convey historical narratives in their party magazines, SD-Kuriren and Dansk Folkeblad, respectively, and in central party documents. The narrative theory being imple

Efficacy of Esomeprazole in NSAIDs Induced Gastric Ulcer: A Meta-Analysis

Background: Gastric ulcers are painful sores with discontinuity in the entire thickness of stomach lining. Proton pump inhibitors (PPIs) are among the major classes of drugs used in treatment of gastric ulcers by inhibiting H+/K+ATPase pump thus reducing acid secretion. The prototype of PPIs is omeprazole, one of its new derivatives, esomeprazole is known to have superior activity against NSAIDs i

Effects of pre-operative isolation on postoperative pulmonary complications after elective surgery : an international prospective cohort study

We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complications after elective surgery during the global SARS-CoV-2 pandemic. We performed an international prospective cohort study including patients undergoing elective surgery in October 2020. Isolation was defined as the period before surgery during which patients did not leave their house or receive visitors

Vitamin D status and dental caries in healthy Swedish children

Background: Vitamin D is crucial for mineralized tissue formation and immunological functions. The purpose of this study was to evaluate the association between vitamin D status and dental status in healthy children with vitamin D supplementation in infancy and at 6 years of age. Method: Eight-year-old children who had participated in a vitamin D intervention project when they were 6 years old wer

The positive net radiative greenhouse gas forcing of increasing methane emissions from a thawing boreal forest‐wetland landscape

At the southern margin of permafrost in North America, climate change causes widespread permafrost thaw. In boreal lowlands, thawing forested permafrost peat plateaus (‘forest’) lead to expansion of permafrost‐free wetlands (‘wetland’). Expanding wetland area with saturated and warmer organic soils is expected to increase landscape methane (CH4) emissions. Here, we quantify the thaw‐induced increa

Probing Electron Correlation on the Attosecond Timescale

This thesis describes how photoemission stimulated by an attosecond pulse train (APT) can be used to extract information on electron correlation in simple quantum systems such as atoms. The emission of the electron by an APT induces a reorganization of the electrons remaining in the ion core. This reorganization causes a change in the trajectory of the emitted electron. An infrared (IR) field is u

Schedule journey lund w12 2016 2

Day Date Start time End Time Title Who Where Sunday 03-jul Arrival Lodging University Guest House 18.00 Ice breaker, dinner Restaurang Stadsparken Monday 04-jul Welcome to Lund University and The Journey! Ecology Building, Blue Hall 9.00 9.30 Welcome and practical information Solveig Zophoniasdottir, Anna Ekberg 9.30 10.00 Welcome to Lund and Lund University Annika Olsson 10.00 10.30 Break 10.30 1

https://www.sustainability.lu.se/sites/sustainability.lu.se/files/schedule_journey_lund_w12_2016_2.pdf - 2026-05-28