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Popular Abstract in English The human plasma proteome containing disease-correlated protein biomarkers reflects the pathological and physiological changes relating to diseases. These biomarkers are of interest to aid in diagnosis, prognosis and monitoring of diseases such as cancer. Because of the interests in the disease-correlated biomarkers, plasma, although is a complex biological sample, spanThe blood/plasma protein biomarker profile represents the pathological and physiological changes relating to human diseases. However, the plasma proteome reflects a high degree of complexity that results in a challenge for most analytical methods in clinical diagnostics. The focus in this thesis is the development and application of several integrated platforms to detect already established protei

Objective: Following the Ross operation, pulmonary autografts tend to dilate over time. This study researches the fate of the pulmonary autograft - at 4.5 years following the modified Ross operation - with special reference to the impact of the modification on (a) pulmonary autograft dilatation, (b) the neo-aortic root geometry, (c) neo-aortic valve function and (d) the coronary artery reserve. Me

SASI03 Autumn 2019 Supplemental Readings These readings have been assigned by the guest lecturers for the course. It is strongly recommended that you read these in preparation for each lecture as they are assigned in the Course Schedule and Study Plan. Berkes, F. 2017. Environmental Governance for the Anthropocene? Social-Ecological Systems, Resilience, and Collaborative Learning, Sustainability 2

https://www.lumes.lu.se/sites/lumes.lu.se/files/sasi03_2019_suplit.docx.pdf - 2026-06-22

https://www.biologyeducation.lu.se/sites/biologyeducation.lu.se/files/2021-12/information_how_to_write_scientific_report_biology_eng.pdf - 2026-06-22

Objective To determine whether environmental control using nocturnal temperature controlled laminar airflow (TLA) treatment could improve the quality of life of patients with persistent atopic asthma. Design Randomised, double-blind, placebo-controlled, parallel-group trial. Setting Nineteen European asthma clinics. Participants 312 patients aged 7-70 with inadequately controlled persistent atopic

27-hydroxycholesterol (27HC), synthesized from cholesterol by the enzyme CYP27A1, differentially impacts estrogen receptor positive (ER+) breast cancer (BC) cell growth depending on estrogen levels. This study examined the association between CYP27A1 expression and prognosis in a cohort of 193 premenopausal patients with lymph node-negative primary BC with limited exposure to adjuvant systemic can

Röststörningar och halsirritation anses ofta bero på gastroesofageal refluxsjukdom (GERD). Emellertid är såväl röstsymtomen som fynden vid svalg- och larynxundersökningar oftast ospecifika hos patienter med misstänkt reflux. Dessutom baseras refluxdiagnosen hos flertalet patienter enbart på just forekorosten av röst- och halssymtom. Därfor är sambanden mellan GERD och röststörningar fortfarande in

This master’s thesis relates to the design of prefabricated balconies. Such balconies are often designed in different ways. A separate investigation of what is technically possible regarding, among other things, supports and balcony sizes must often be performed in every project involving balconies. Three kinds of solutions are presented. These are tie rod, cantilever and column supported balconie

Institutional theory of economic growth argues that the long-term development of a country is greatly influenced by quality of its institutions. On its turn, good institutions would form more naturally in countries with better income distributions than more unequal countries. One of the main references used to support this idea used by researchers is the case of Latin America, especially Argentina

DNA copy number aberrations (CNAs) are a hallmark of cancer genomes. However, little is known about how such changes affect global gene expression. We develop a modeling framework, EPoC (Endogenous Perturbation analysis of Cancer), to (1) detect disease-driving CNAs and their effect on target mRNA expression, and to (2) stratify cancer patients into long-and short-term survivors. Our method constr

A number of 'freedom of religion v. secular policies' cases in the European Court of Human Rights (and, before 1998, the European Commission of Human Rights) emanating from Turkey suggest that the Court endorses Turkish secular policies at the expense of Turkish Muslims' human rights. These cases include the high-profile case of Leyla &#350&semicahin v. Turkey that was decided

In bottom-up mass spectrometry (MS)-based proteomics, peptide isotopic and chromatographic traces (features) are frequently used for label-free quantification in data-dependent acquisition MS but can also be used for the improved identification of chimeric spectra or sample complexity characterization. Feature detection is difficult because of the high complexity of MS proteomics data from biologi

OBJECTIVES: The support of the pulmonary autograft root by the fibromuscular left ventricular outflow tract is emphasized to address the concern related to the dilatation of the pulmonary autograft structures in the paediatric population. METHODS: This retrospective study analyses the outcomes of 75 children who were operated between 1998 and 2012 with the subannular interrupted sutures technique

To study the biochemistry of processing of a soluble protein Ag by an APC, we investigated how 125 I-labeled human insulin (HI) is processed in situ by TA3 mouse hybridoma B cells. Fractionation of TA3 cells into their extracellular, plasma membrane-associated and intracellular compartments coupled with the use of HPLC enabled us to analyze several peptides derived from each compartment. One HI

Introduction. Perioperative chemotherapy is the standard treatment for patients with locally advanced resectable gastric cancer. The prognostic relevance of MSI status in patients undergoing neoadjuvant chemotherapy remains unclear. Aim. To study the prognostic significance of MSI in gastric cancer patients undergoing perioperative CT. Materials and methods. The study included 173 patients with lo

Background: Non-beta-hemolytic streptococci (NBHS) are a common cause of infective endocarditis (IE). Echocardiography is used to diagnose IE, but it is not known which patients with NBHS bacteremia should undergo echocardiography.Method: Medical records of patients with NBHS bacteremia in southern Sweden from 2012-2014 were studied retrospectively. The patients were divided into two cohorts. In t

The presence of diabetes mellitus is rarely addressed in acute lower limb ischaemia (ALLI). The aim of this study was to evaluate the outcome of local intra-arterial thrombolysis for ALLI in patients with diabetes mellitus (DM). Outcome of all thrombolytic events performed in an endovascular first-strategy centre during a 13-year period between 2001 and 2013 in patients with ALLI were followed to

Cardiac resynchronization therapy (CRT) reduces mortality and morbidity in selected patients with heart failure (HF), but up to 1/3 of patients are nonresponders. Sum absolute QRST integral (SAI QRST) recently showed association with mechanical response on CRT. However, it is unknown whether SAI QRST is associated with all-cause mortality and HF hospitalizations in patients undergoing CRT. The stu