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Product-service systems: Panacea or myth?

Popular Abstract in Swedish Dagens storskaliga tillverkning baseras på varor med relativt kort livstid och lågt pris. Vinsterna för tillverkarna kommer från den stora mängden sålda varor. Det finns dock inom många industribranscher krympande vinstmarginaler och många företag söker därför efter nya källor för att uppnå bättre rörelseresultat. Även miljöfrågorna är en utmaning för industrin. VäxandeLife cycle environmental problems have been addressed by a number of strategies. However, the results are mostly lamentable because solutions are searched for within the same paradigms that give rise to the problems. This research questions the vision of linear material growth and searches for ways to sustain economic growth without putting the natural environment under stress. The research explor

Long DNA isolation and imaging using lateral displacement arrays integrated with DNA combing

We demonstrate proof of principle of an efficient and simple method combining sample preparation and stretching of DNA in a single device that can be used as basis for an integrated portable system for optical DNA mapping. An important bottleneck for DNA mapping, as well as for other methods, is the isolation of long DNA molecules from a background of contaminants such as shorter DNA fragments, dy

A lung function threshold for survival? - FEV1Q and mortality in patients with COPD and chronic respiratory failure

INTRODUCTION: The FEV1 quotient (FEV1Q), calculated as the index between FEV1 and a theoretical lower survivable FEV1 threshold of 0.4L for females and 0.5L for males, has been investigated as a novel method of interpreting results from lung function testing. The applicability of the FEV1Q in populations with chronic respiratory failure has not been studied, and the continuous association between

Min framtids dag är ljus och lång -Musiker och musiklärare berättar om utbrändhet

Title: The future is looking bright - Studies of burnout among musicians and music teachers. Since late 1970's, the burn-out-syndrome has been researched in several ways, especially among people working in care-oriented employments. The object with this study is to find out the biggest issues about why musicians and music teachers burn themselves out. This is based on musicians and music teach

Identifying bacteria using DNA binding maps

We have developed an assay, based on nanofluidic channels and fluorescence microscopy, for optical mapping of DNA based on competitive binding between two molecules - one fluorescent and one sequence selective. From the experimental data we can extract binding constants for the two competing DNA binders, which may be subsequently used to calculate a theoretical reference map of any DNA with known

Sample preparation for single-cell whole chromosome analysis

In this work we present an integrated system for whole chromosome analysis of single bacterium. Using whole genome barcoding techniques, which offer direct and rapid microscopic visualization of the entire genome in one field-of-view, we aim to rapidly identify individual bacterium. We are developing our device to achieve the crucial, and difficult process of isolating a bacterium, removing the DN

Beta secretase 1-dependent amyloid precursor protein processing promotes excessive vascular sprouting through NOTCH3 signalling

Amyloid beta peptides (Aβ) proteins play a key role in vascular pathology in Alzheimer’s Disease (AD) including impairment of the blood–brain barrier and aberrant angiogenesis. Although previous work has demonstrated a pro-angiogenic role of Aβ, the exact mechanisms by which amyloid precursor protein (APP) processing and endothelial angiogenic signalling cascades interact in AD remain a largely un

Dynamic site characterization for brownfield risk management

Common remediation and land management approaches often preclude economically attractive and low risk brownfield redevelopment. The authors argue that recently developed dynamic site characterization techniques can greatly improve sound decision making on land revitalization options. A number of these in-situ soil and groundwater test methods, such as MIP, ROST™/UVOST™, XRF and BAT, based on geote

Image-Based Dosimetry Procedures

This chapter describes methods and procedures that can be used to calculate the absorbed dose distribution based on quantitative SPECT/PET images. In this context, quantitative images mean images corrected for various physical effects (among them are photon attenuation, scatter contribution, dead time) in such a way that the values of each voxel can then be translated into units of activity by a c

Qmod 2014 final program with welcome 20140819 1

4th September 2013, Wednesday 17th QMOD-ICQSS Conference 3rd-5th September, 2014 Prague, Czech Republic Program Jointly organized by: Lund University, Linköping University & University of Economics, VŠE, Prague Welcome Address from the Founders of QMOD-ICQSS It is our great pleasure to welcome you to the 17th QMOD-ICQSS conference, the conference which has become one of the largest scientific conf

https://www.ses.lu.se/en/sites/ses.lu.se.en/files/qmod_2014_final_program_with_welcome_20140819_1.pdf - 2026-05-30

Detailed characterization of plasmids carrying resistance genes using optical DNA mapping

We present an assay, based on optical DNA mapping in nanochannels that is capable of characterizing the plasmid content of bacterial isolates resistant to antibiotics in a fast an detailed way. In a single experiment we determine the number of different plasmids in each sample, their size, as well as a barcode that can be used for plasmid identification and tracing. In addition we demonstrate that

Tunable separation and DNA manipulation in metal coated pillar arrays

Implementing electrically connected metal-coated posts in a Deterministic Lateral Displacement (DLD) device and applying electric fields, we use electrokinetics to achieve tunable particle separations and to trap and manipulate DNA. The strength of DLD stems from its typically binary behavior. Particles move in one out of two trajectories based on their effective size. For particles that are close

ACouWash : A standalone instrument for the washing, separation and enrichment of cells.

We developed the AcouWash (Figures 1 and 2), a benchtop instrument for flow-through cell and particle separation by acoustophoresis. Building on previous research [1-4] AcouWash can re-suspend cells in new medium, separate cells based on size or acoustic properties, or enrich cells, Figure 3. We present our initial evaluation of AcouWash regarding size-based separation of particles, cell washing,

Indications and timings for caffeine initiation in preterm infants

RATIONALE: Caffeine is commonly used in preterm infants to improve respiratory function. However, the optimal strategies for caffeine initiation have not been defined. OBJECTIVES: To evaluate the relative benefits and harms of different indications and timings for caffeine initiation in preterm infants. SEARCH METHODS: We searched MEDLINE, Embase, CENTRAL, and trial registries up to 23 April 2025.

Exploring the Archive : A Problematization Lens for Conducting Critical IS Research

Critical IS research agendas are more important than ever if we wish to uncover the unanticipated and potentially harmful consequences of digital technologies. Developed from Michel Foucault’s late work, we introduce the problematization lens as a critical IS research strategy for exploring discursive commitments embedded in digital phenomena. The problematization lens is characterized by a geneal

Cerebral extracellular calcium activity in severe hypoglycemia : Relation to extracellular potassium and energy state

The changes in extracellular Ca2+ (Cae) and K+ (Ke) activities were studied in the rat brain during insulin-induced hypoglycemia. At about the time of onset of isoelectric EEG in severe insulin-induced hypoglycemia (300-g male Wistar rats under 70% N2O anaesthesia), there was an increase in Ke which, at ∼13 mM, was associated with a fall in Cae. Ke peaked at 48 ± 12 mM, and Cae at 0.18 ± 0.28 mM.