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Even with the availability of targeted drugs, allogeneic hematopoietic cell transplantation (allo-HCT) is the only therapy with curative potential for patients with CLL. Cure can be assessed by comparing long-term survival of patients to the matched general population. Using data from 2589 patients who received allo-HCT between 2000 and 2010, we used landmark analyses and methods from relative sur
This dissertation is about the view of writing. One of the intentions of the study is to analyse different notions of writing that become manifest in media debates about student writing. Another intention is to analyse conceptions of writing in curricula and course plans for upper secondary school in Sweden from 1970 to 2011. Drawing from theories of critical discourse analysis, the study aim
P-type ATPases from the P4 subfamily (P4-ATPases) are energy-dependent transporters, which are thought to establish lipid asymmetry in eukaryotic cell membranes. Together with their Cdc50 accessory subunits, P4-ATPases couple ATP hydrolysis to lipid transport from the exoplasmic to the cytoplasmic leaflet of plasma membranes, late Golgi membranes, and endosomes. To gain insights into the structure
Children are entitled to an economic standard that is comparable with the standard that their parents have. This principle is reflected in the child’s right to receive an addition to the average maintenance allowance, a so-called standard addition. In year 2013, the Supreme Court stated that a child who lives alternately with their parents are entitled to a maintenance allow-ance. By applying arti
Human rights are the basis by which the dignity of the human being is guaranteed. This is especially important in the relationship between persons and governments, who on the one hand have great power in form of legislation over these persons, but on the other hand must ensure the protection of human rights. A problem may arise when these two opposing forces of the State collide,1 as the individua
Den samiska ursprungsbefolkningens traditionella territorium breder ut sig över delar av Sverige, Norge, Finland och Ryssland. Samisk kultur är starkt kopplad till rennäringen, som kräver vidsträckta och sammanhängande marker där renen ostörd kan få tillgång till naturbete. Den här uppsatsen undersöker nuvarande möjligheter för samer i Sverige att påverka beslutsprocesser rörande användning av marThe traditional territory of the indigenous Sami people stretches into Sweden, Norway, Finland and Russia. Sami culture is strongly connected to reindeer husbandry, which requires vast and coherent land where the reindeer can access natural pasture without disturbances. This thesis examines present possibilities for Sami in Sweden to impact decision-making processes regarding use of land and natur
Att vara ett offer för människohandel (trafficking) genom prostitution eller annan sexuell exploatering innebär att offret utsätts för uppenbara kränkningar av sina mänskliga rättigheter i form av våldtäkt, fysiskt våld, tvångsprostitution och sexuellt slavarbete. Efter att ha undkommit sin fångenskap är offret i stort behov av socialt och medicinskt stöd. Utöver detta kan det finnas ett stort behBeing a victim of trafficking for sexual purposes could mean being subject to the most flagrant human rights violations there is, such as forced prostitution, rape, physical violence and sexual enslavement. After escaping captivity, the victim needs both social and medical assistance. Additionally, a victim could have a strong desire to reside in the country where the exploitation has taken place
Today, investors look for more than just the potential return a company can bring when making investment decisions. An increased demand to invest sustainably has created a demand for investors to screen companies via ESG scores. In this thesis, we therefore aim to examine if Bloomberg’s ESG disclosure scores can be used as screening tools and proxies for the most common risk and return measures, v
Urban populations are growing rapidly with several environmental and social effects in the process. At a governance level, resources go from being regulated by federal and state institutions into being considered urban areas governed by the local government. Nevertheless, this can neglect the enforcement of existing laws for many reasons that deteriorate urban resources due to a rivalry in the typ
The concept of experimentation is increasingly promoted to facilitate social learning for sustainability transitions. Experiments are collaborative initiatives designed to generate knowledge and test innovative practices to address a collective sustainability challenge. However, it is often unclear whether experiments generate any impact beyond the initial project scope. Recent literature has call
Prostate specific antigen (PSA) is an important biomarker for diagnosis and prognosis of prostate cancer. Herein, microcontact PSA-imprinted surface plasmon resonance (SPR) sensor chip was developed for sensitive, real-time detection of PSA. The imprinted chip was prepared in the presence of methacrylic acid (MAA) as functional monomer and ethylene glycol dimethacrylate (EGDMA) as cross-linker via
Popular Abstract in English Morphologically marked case is a salient Standard Arabic feature without parallel in Arabic dialects. As such it is a grammatical system learned by native speakers of Arabic through formal education. Case endings are traditionally regarded as an essential feature of Standard Arabic, but morphological case endings are used only sporadically in extemporaneous speech in foMorphologically marked case is a salient Standard Arabic feature without parallel in Arabic dialects. As such it is a grammatical system learned by native speakers of Arabic through formal education. Case endings are traditionally regarded as an essential feature of Standard Arabic, but morphological case endings are used only sporadically in extemporaneous speech in formal situations where Standa
Environmental conditions, dispersal lags, and interactions among species are major factors structuring communities through time and across space. Ecologists have emphasized the importance of biotic interactions in determining local patterns of species association. In contrast, abiotic limits, dispersal limitation, and historical factors have commonly been invoked to explain community structure pat
The incretin - glucose-dependent insulinotropic polypeptide (GIP) - and the pro-inflammatory cytokine osteopontin are known to have important roles in the regulation of adipose tissue functions. In this work we show that GIP stimulates lipogenesis and osteopontin expression in primary adipocytes. The GIP-induced increase in osteopontin expression was inhibited by the NFAT (the transcription factor
Background: Long-term exposure to air pollution is a hypothesized risk factor for ischemic stroke. In a large case-control study with a complete study base, we investigated whether hospital admissions for ischemic stroke were associated with residential concentrations of outdoor NOx, as a proxy for exposure to air pollution, in the region of Scania, Southern Sweden. Methods: We used a two-phase ca
Background: Cohort studies of the relationship between air pollution exposure and chronic health effects require predictions of exposure over long periods of time. Objectives: We developed a unified modeling approach for predicting fine particulate matter, nitrogen dioxide, oxides of nitrogen, and black carbon (as measured by light absorption coefficient) in six U.S. metropolitan regions from 1999
A bioanode with high current density and coulombic efficiency was developed by co-immobilization of pyranose dehydrogenase from Agaricus meleagris (AmPDH) with the dehydrogenase domain of cellobiose dehydrogenase from Corynascus thermophiles (recDHCtCDH) expressed recombinantly in Escherichia coli. The two enzymes were entrapped in Os-complex modified electrodeposition polymers (Os-EDPs) with spec
More than 90% of DNA does not code for proteins and for a long time these sequences were referred to as “junk DNA” due to their unknown purpose. With the advent of new technologies it is now known, that the non-coding part of the genome is of great importance for regulating gene expression and is therefore indispensable. Transposable elements comprise about 50% of the genome and co-exist as symbio
BackgroundDimethyl sulfoxide (DMSO) is essential for the preservation of liquid nitrogen-frozen stem cells, but is associated with toxicity in the transplant recipient. Study Design and MethodsIn this prospective noninterventional study, we describe the use of DMSO in 64 European Blood and Marrow Transplant Group centers undertaking autologous transplantation on patients with myeloma and lymphoma
Background and purpose. The purpose of this study was to evaluate the performance of gantry angle optimisation (GAO) compared to equidistant beam geometry for two inverse treatment planning systems (TPSs) by utilising the information obtained from a range of treatment plans. Material and methods. The comparison was based on treatment plans generated for four different head and neck (H&N) cance
