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This thesis focuses on developing and characterizing novel models for studying osteoclasts with an emphasis on how mutations abolishing osteoclastic acidification affect osteoclast signaling and bone remodeling, as well as how to treat patients bearing these rare mutations. Bone remodeling is under normal circumstances a tightly balanced process where resorption of bone by osteoclasts is followed

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I svensk rätt finns i dagsläget ingen bestämmelse om allmän skyldighet att bistå nödställda. Frågan har, historiskt sett, behandlats i utredningar och flertalet motioner har lagts fram men alla har gått i avstyrkande riktning. I brist på en straffsanktionerad hjälpplikt kan enskilda trots förmåga och hjälpmedel välja att inte ingripa utan att straffas. Lagstiftaren menar att försiktighet måste iak

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This essay compares the two Swedish municipalities Landskrona and Värnamo, in order to understand the difference in achieved integration on the labor market. By using Mill’s method of disagreement, and conducting interviews with persons with key positions in the integration process, based on theories of integration, the essay reaches the conclusion that authorities can be the difference between su

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Bioenergy plays a major role in the renewable energy supply and is projected to be an important part of the path towards a decarbonised society. Over the past decade, increasing attention has been given to agricultural bioenergy to act as a multifunctional climate mitigation strategy. Energy crops may mitigate climate change while simultaneously contributing to reducing the negative environmental

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Meeting the Paris Agreement’s temperature goals requires limiting future carbon emissions, yet current policies make temporarily overshooting the 1.5°C target likely. The potential climate feedback from destabilizing peatlands, storing large amounts of carbon, remains poorly quantified. Using the reduced-complexity Earth System Model OSCAR with an integrated peat carbon module, we found that acros

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To overcome soil nutrient limitation, many plants have developed complex nutrient acquisition strategies including altering root morphology, root hair formation or colonization by arbuscular mycorrhizal fungi (AMF). The interactions of these strategies and their plasticity are, however, affected by soil nutrient status throughout plant growth. Such plasticity is decisive for plant phosphorus (P) a

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In the struggle to reach the national environmental policy objectives, environmental compensation has emerged as a possible policy tool that may contribute to achieving the objectives. In Sweden, environmental compensation is legally mandated mainly in cases of exploitation within Natura 2000 areas and nature reserves, which is handled through the Swedish Environmental Code. In contrast, regulatorIn the struggle to reach the national environmental policy objectives, environmental compensation has emerged as a possible policy tool that may contribute to achieving the objectives. In Sweden, environmental compensation is legally mandated mainly in cases of exploitation within Natura 2000 areas and nature reserves, which is handled through the Swedish Environmental Code. In contrast, regulator

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The 8.2 ka bp cooling event is assumed to be the most clearly marked abrupt climate event in the Holocene at northern mid- to high latitudes. In this study, we simulate the vegetation responses to the 8.2 ka bp climate change event over Europe and Northern Africa. Our results show that all dominant plant functional types (PFTs) over Europe and North Africa respond to these climate changes, but the

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The circumpolar Arctic is currently facing multiple global changes that have the potential to alter the capacity of tundra soils to store carbon. Yet, predicting changes in soil carbon is hindered by the fact that multiple factors simultaneously control processes sustaining carbon storage and we do not understand how they act in concert. Here, we investigated the effects of warmer temperatures, en

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Recent accelerated warming over the Arctic coincides with sea ice reduction and shifting patterns of land cover. We use a state-of-the-art regional Earth system model, RCAO-GUESS, which comprises a dynamic vegetation model (LPJ-GUESS), a regional atmosphere model (RCA), and an ocean sea ice model (RCO), to explore the dynamic coupling between vegetation and sea ice during 1989–2011. Our results sh

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Agricultural intensification and the subsequent fragmentation of semi-natural habitats severely restrict pollinator and pollen movement threatening both pollinator and plant species. Linear landscape elements such as hedgerows are planted for agricultural and conservation purposes to increase the resource availability and habitat connectivity supporting populations of beneficial organisms such as

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Understanding the transition of biosphere‐atmosphere carbon exchange between glacial and interglacial climates can constrain uncertainties in its future projections. Using an individual‐based dynamic vegetation model, we simulate vegetation distribution and terrestrial carbon cycling in past cold and warm climates and elucidate the forcing effects of temperature, precipitation, atmospheric CO2 con

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The effect of mineral fertilization and its application pattern on microbial activity and the subsequent CO2 and CH4 emissions arising from soil organic matter (SOM) or added substrate remains unclear. We quantified the decomposition of 13C-labeled straw and the priming effect (PE) governed by the N and P fertilizer application pattern during a 100-day experiment in a flooded soil. Straw addition

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Scholarly literature on science-policy interaction is typically dividedbetween advocating that science and policy need to be broughtcloser together or separated. In a recent article in this journal,Sundqvist and colleagues [Sundqvist et al. (2018) Oneworld ortwo? Science–policy interactions in the climate field, Critical PolicyStudies, 12:4, 448–468] proposed a typology that structures thisdebate.

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The Community Atmosphere-Biosphere Land Exchange model (CABLE) is a land surface model (LSM) that can be applied stand-alone and provides the land surface-atmosphere exchange within the Australian Community Climate and Earth System Simulator (ACCESS). We describe new developments that extend the applicability of CABLE for regional and global carbon-climate simulations, accounting for vegetation re

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The “Green Sahara” is a period when North Africa was characterized by vegetation cover and wetlands. To qualitatively identify the orbital-climatic causation of the Green Sahara regime, we performed dynamic vegetation model (LPJ-GUESS) simulations, driven by climate forcings from coupled general circulation model (EC-Earth) simulations for the mid-Holocene, in which the vegetation is prescribed to

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Across the Arctic, the net ecosystem carbon (C) balance of tundra ecosystems is highly uncertain due to substantial temporal variability of C fluxes and to landscape heterogeneity. We modeled both carbon dioxide (CO2) and methane (CH4) fluxes for the dominant land cover types in a ~100-km2 sub-Arctic tundra region in northeast European Russia for the period of 2006–2015 using process-based biogeoc

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Large grazers are known to affect ecosystem functioning even to the degree where ecosystems transition to another vegetation state. Alongside the vegetation change, several features of ecosystem functioning, such as ecosystem carbon sink capacity and soil carbon mineralisation rates, may be altered. It has remained largely uninvestigated how the grazing effects on carbon cycling processes depend o

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Boreal forests exchange large amounts of carbon dioxide (CO2) with the atmosphere. A managed boreal landscape usually comprises various potential CO2 sinks and sources across forest stands of varying age classes, clear-cut areas, mires, and lakes. Due to this heterogeneity and complexity, large uncertainties exist regarding the net CO2 balance at the landscape scale. In this study, we present the