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Popular Abstract in Swedish Denna avhandling handlar om antikroppar. Antikroppar är proteiner som bildas av vårt immunförsvar för att skydda oss mot farliga ämnen i vår omgivning, som tex bakterier. På grund av antikroppars unika uppbyggnad och funktion utnyttjas ofta dessa på konstgjord väg. De kan injiceras i kroppen för att bota någon sjukdom eller användas på laboratoriet i olika analyser. InnIn vitro generation of antibody fragments of desired specificity and affinity plays an important role since it permits the generation of reagents which may be valuable for diagnostic and therapeutic applications. Furthermore, the kinetic parameters for an antibody-antigen interaction, rather than the affinity, has shown to correlate with biological functions like virus neutralization. This points

Uncontrollable events such as adverse weather and volatile prices present considerable risks for arable farmers. Soil natural capital, which views the capacity of soil biodiversity to generate ecosystem services as a component of farm capital, could be important for the stability and resilience of arable production systems. We investigate therefore whether managing soil natural capital could be an

Wood is a hygroscopic material; always striving to reach equilibrium with the surrounding air, and consequently the moisture content is different in different climate conditions. The strength of wood is directly dependent on the moisture content, lower moisture content leads to increasing strength. Generally, state moisture equilibrium is seldom obtained because the moisture transport in wood is v

Simultaneously enhancing ecosystem services provided by biodiversity below and above ground is recommended to reduce dependence on chemical pesticides and mineral fertilisers in agriculture. However, consequences for crop yield have been poorly evaluated. Above ground, increased landscape complexity is assumed to enhance biological pest control, whereas below ground, soil organic carbon is a proxy

Soil organic matter (SOM) constitutes the largest terrestrial C pool. An emerging, untested, view is that oxidation and depolymerization of SOM by microorganisms promote the formation of SOM-mineral associations that is critical for SOM stabilization. To test this hypothesis, we performed laboratory-scale experiments involving one ectomycorrhizal and one saprotrophic fungus that represent the two

Boreal trees rely on their ectomycorrhizal fungal symbionts to acquire growth-limiting nutrients, such as nitrogen (N), which mainly occurs as proteins complexed in soil organic matter (SOM). The mechanisms for liberating this N are unclear as ectomycorrhizal fungi have lost many genes encoding lignocellulose-degrading enzymes present in their saprotrophic ancestors. We hypothesized that hydroxyl

Land-use changes, pollution and climate warming during the 20th century havecaused changes in biodiversity across the world. However, in many cases, the environmental drivers are poorly understood. To identify and rank the drivers currentlycausing broad-scale floristic changes in N Europe, we analysed data from two vascularplant surveys of 200 randomly selected 2.5 9 2.5 km grid-squares in Scania,

The majority of nitrogen in forest soils is found in organic matter-protein complexes. Ectomycorrhizal fungi (EMF) are thought to have a key role in decomposing and mobilizing nitrogen from such complexes. However, little is known about the mechanisms governing these processes, how they are regulated by the carbon in the host plant and the availability of more easily available forms of nitrogen so

The amounts of carbon allocated to the fungal partner in ectomycorrhizal associations can vary substantially depending on the plant growth and the soil nutrient conditions, and the fungus may frequently be confronted with limitations in carbon. We used chemical analysis and transcriptome profiling to examine the physiological response of the ectomycorrhizal fungus Paxillus involutus to carbon star

Soil salinization is a growing threat to global agriculture and carbon (C) sequestration, but to date it remains unclear how microbial processes will respond. We studied the acute response to salt exposure of a range of anabolic and catabolic microbial processes, including bacterial (leucine incorporation) and fungal (acetate incorporation into ergosterol) growth rates, respiration and gross N min

Background: Presence of circulating tumor cells (CTCs) is a validated prognostic marker in metastatic breast cancer. Additional prognostic information may be obtained by morphologic characterization of CTCs. We explored whether apoptotic CTCs, CTC clusters and leukocytes attached to CTCs are associated with breast cancer subtype and prognosis at base-line (BL) and in follow-up (FU) blood samples i

We investigated fungal growth and community composition in buried meshbags, amended with apatite, biotite or hornblende, in Norway spruce (Picea abies) forests of varying nutrient status. Norway spruce needles and soil collected from forests overlying serpentinite had low levels of potassium and phosphorus, those from granite had low levels of magnesium, whereas those from amphibolite had comparab

In saline soils, the severity of drought for the soil microbial community is exacerbated by accumulating concentrations of salts during drying. In this study we investigated how bacterial growth and respiration responses to drying-rewetting were affected by salinity. To do this, we adjusted a non-saline soil to four different salinities (0, 2, 7 and 22 mg NaCl g−1), followed by addition of plant m

Many small farmland ponds are built for nutrient retention, the conservation of biodiversity or both, yet they are relatively neglected habitats. For example, little is known about the potential for ponds to influence populations of beneficial terrestrial insects, deliver ecosystem services across the aquatic-terrestrial boundary and affect crop yield in insect-pollinated cash crops.We assessed wh

Agricultural fertilization significantly affects arbuscular mycorrhizal fungal (AMF) community composition. However, the functional implications of community shifts are unknown, limiting understanding of the role of AMF in agriculture. We assessed AMF community composition at four sites managed under the same nitrogen (N) and phosphorus (P) fertilizer regimes for 55 yr. We also established a glass

Understanding the effects of different agricultural practices on the mycorrhizal symbiosis is important for agricultural production and the sustainable use of soil. We investigated the composition and diversity of arbuscular mycorrhizal fungi (AMF) in soils from fields under different agricultural practices (conventional and organic cereal fields, leys and permanent pastures) in southern Sweden. T

Predatory arthropods contribute to biological control, but to become an integral part of agricultural management, it is essential to identify drivers of their spatio-temporal distribution at the landscape scale. This study focuses on how agricultural land use affects the community composition, emergence and dispersal tendency of predatory arthropods. The arthropods were collected in emergence trap

Air-starved combustion of biomass and fossil fuels releases aerosols, including airborne carbonaceous particles, causing negative climatic and health effects. Radiocarbon analysis of the elemental carbon (EC) fraction can help apportion sources of its emission, which is greatly constrained by the challenges in isolation of EC from organic compounds in atmospheric aerosols. The isolation of EC usin

The spatial extent of ecological processes has consequences for the generation of ecosystem services related to them. However, management often fails to consider issues of scale when targeting ecological processes underpinning ecosystem services generation. Here, we present a framework for conceptualizing how the amount and spatial scale (here discussed in terms of extent) of management interventi