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Background: Most multiple sclerosis (MS) patients succumb to a progressive phenotype. Continued lymphocyte activity in the brain, microglia-mediated injury, iron deposition, and oxidative stress are characteristics of progressive MS. Objective: As minocycline and hydroxychloroquine have been shown to inhibit microglia, we evaluated their effects on other outcomes relevant for progression. Methods:

To evaluate the feasibility and acceptability of a therapist-guided, mobile app-assisted behavioural treatment for children and adolescents with chronic tic disorders, compared to videoconference-delivered behaviour therapy for tics. Pilot, single-blind, two-arm randomised controlled trial (RCT). A specialist tic disorder clinic for children and adolescents in Denmark. 30 participants with Tourett

Scholte wave surveys were conducted at both the laboratory and field scales to evaluate the reliability of distributed acoustic sensing (DAS) with a fiber-optic cable resting on top of unconsolidated sedimentary deposits to determine the distribution of S-wave velocity underneath. Laboratory measurements performed in a controlled environment at the Deltares Laboratory facility demonstrated that DA

Micropollutant removal is a key component of the revised Urban Wastewater Treatment Directive (UWWTD) and can be achieved with ozonation. During ozonation, the composition of the wastewater matrix and the targeted treatment level for individual micropollutants or groups of such compounds affect ozone consumption. In this work, it was hypothesized that nitrite scavenging, the point of dosing (befor

BackgroundAmbulance clinicians increasingly refer patients to self-care, positioning ambulance service within a wider gatekeeping role and necessitating the assessment of whether self-care is a safe option or if further support is needed. Contrary to primary healthcare centre (PHC) referrals, self-care referrals often lack structured follow-ups, with the decision consequences remaining underexplor

Hydraulic balancing is key to ensure proper operation of the heating system. When the heating system is not hydraulically balanced, heat is unevenly distributed across dwellings resulting in a wide temperature spread, overheating, and consequently, wastage of energy. In this paper, we study to which extent hydraulic imbalance affects the thermal energy demand of buildings. Furthermore, key variabl

Sensitive detection of short nucleic acids is used to identify viral and bacterial diseases, detect biomarkers of cancer, as well as in gene expression studies. Currently available techniques such as PCR, electrochemical detection and SPR are typically costly and often require amplification of the DNA. Here, we demonstrate a sensing system for picomolar detection of short single-stranded DNA by fl

This paper adds to the growing body of literature on digitally mediated preaching by using actor–network theory (ANT) in conjunction with Amanda Lagerkvist’s work on digital media as theoretical lenses to describe and discuss what we term “the paradox of (im)perfection”. This paradox refers to the tension between an ideal of perfection and an ideal of imperfection (or vulnerability) as experiencedThis paper adds to the growing body of literature on digitally mediated preaching by using actor–network theory (ANT) in conjunction with Amanda Lagerkvist’s work on digital media as theoretical lenses to describe and discuss what we term “the paradox of (im)perfection”. This paradox refers to the tension between an ideal of perfection and an ideal of imperfection (or vulnerability) as experienced

PURPOSE: Filter exchange imaging (FEXI) is sensitive to the rate of diffusional water exchange, which depends, eg, on the cell membrane permeability. The aim was to optimize and analyze the ability of FEXI to infer differences in the apparent exchange rate (AXR) in the brain between two populations.METHODS: A FEXI protocol was optimized for minimal measurement variance in the AXR. The AXR variance

ABSTRACT Background We explored the impact of anastomotic leakage (AL) on the oncological outcome after anterior resection (AR) for rectal cancer which is still controversial.. Local recurrence (LR) and overall recurrenc(OAR) and cancer-specific survival were analysed. Method Patients undergoing AR for rectal cancer with a registered AL between 1995 and 1997 and a control group were identified in

Although the repair of ventral abdominal wall hernias is one of the most commonly performed operations, many aspects of their treatment are still under debate or poorly studied. In addition, there is a lack of good definitions and classifications that make the evaluation of studies and meta-analyses in this field of surgery difficult. Under the auspices of the board of the European Hernia Society

For the assessment of personal exposure, information about the concentration of pollutants when people are in given indoor environments (occupancy time) are of prime importance. However this kind of data frequently is not reported. The aim of this study was to assess differences in particle characteristics between occupancy time and the total monitoring period, with the latter being the most frequ

Purpose – This study aims to understand master’s students’ experiences of service-learning, following their participation in a workshop with local social innovators whose activities had contributed to combating poverty in East Africa and to determine how this participation affected work on the students’ theses. The authors also explored possible gender differences in this context. Design/methodolo

This study explores how traffic safety implementation at local level in line with the 2030 Agenda for Sustainable Development is characterised. By investigating interactions between traffic safety and other sustainability goals (synergies), as well as identifying contradictions between goals and conflicting interests (challenges), the study aims to pinpoint the main enablers for implementing traff

Alongside global acknowledgements of the gendered nature of conflict, the academic field of transitional justice is shifting towards the newly emerging concept of transformative justice. Within this, reparations are particularly seen as the most agent-centric tool for structural transformation. In northeastern Nigeria, the conflict between Boko Haram and the state has seen a prevalence of conflict

Preventing and mitigating damage to the surroundings arising from process safety incidents is an important aspect of process safety. Risk-informed or risk-based decision-making are cornerstones in most countries’ regulatory regimes for land-use planning. However, the design and implementation of the regulations vary significantly - from countries that have chosen a highly standardized set of rules

Microsoft Word - Bilaga 1 - Fördelning av ansvar beslutsbefogenheter delegationer inom CEC from 2019-04-15 - final Bilaga 1 - Fördelning av ansvar och beslutsbefogenheter samt delegationer inom CEC, beslut 2019-04-12, STYR 2019/749 1   Fördelning av ansvar och beslutsbefogenheter samt delegationer inom CEC från och med 2019-01-15 Föreståndare Motsvarar prefekt, se gällande chefskontrakt och arbets

https://www.cec.lu.se/sites/cec.lu.se/files/delegationsordning_cec_from_190415.pdf - 2026-07-02