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Background: Surgical resection of post-chemotherapy residual masses for metastatic seminoma is discussed controversially with regard to oncological and functional outcome. Furthermore, the role of FDG-PET/CT to detect vital seminoma is still unclear. It is the aim of this study is to report the outcomes of patients with pure seminoma who underwent PC-RPLND. Methods: In this retrospective multi-ins
BackgroundThe use of stereotactic body radiotherapy (SBRT) to definitively treat oligometastases in prostate cancer has drawn large clinical and research interests within radiation oncology. However, the evidence is considered in its early stages and there is currently no systematic review of randomized controlled trials (RCTs) in this field. We aimed to evaluate the efficacy and safety of SBRT as
Background: Pathologist-read tumor-infiltrating lymphocytes (TILs) have showcased their predictive and prognostic potential for early and metastatic triple-negative breast cancer (TNBC) but it is still subject to variability. Artificial intelligence (AI) is a promising approach toward eliminating variability and objectively automating TILs assessment. However, demonstrating robust analytical and p
Land use change has been observed to cause profound impacts on sustainability, particularly when the change is not well planned and co-coordinated. In Kenya the government is promoting diversification of crops to embrace high value crops and drought resistant crop varieties in efforts to reduce poverty in rural areas. Sugar beet is one of the crops considered as an option in this context. Adoption
Clothing evaporative resistance is one of the most important parameters for clothing comfort. The clothing evaporation resistance can be measured on a sweating guarded hotplate, a sweating thermal manikin or a human subject. The sweating thermal manikin gives the most accurate value on evaporative resistance of the whole garment ensemble compared to the other two methods. The determination of clot
Popular Abstract in Swedish Avfall har alltid uppkommit i alla samhällen i alla tider. Det vanligaste sättet att hand om det har varit att samla avfallet i soptippar (deponier) på mark som ansetts obrukbar, t.ex. i sankmarker utanför bebyggelsen. I takt med ökad konsumtion och produktion har också mängderna avfall ökat. Anledningen till att avfall och avfallshantering kommit alltmer i fokus i miljA methodology based on an analytical protocol for evaluation of hazards from landfill leachate and solid waste is described. A dynamic analytical protocol, the LAQUA protocol, including measurements of inorganic and water-quality parameters, polar and non-polar organic marker compounds, and toxicity, was constructed. An acute toxicity test, using the brackish water crustacean Artemia salina as tes
This doctoral dissertation deals with a phenomenon that is often referred to in sports, but still poorly understood from a scientific angle: psychological momentum (PM). No consensus has been agreed on how to label this phenomenon, and other terms such as momentum or behavioural momentum (BM) are often used interchangeably. In everyday language, PM can be explained by periods in a match where ever
Current food systems pose one of the greatest health and environmental challenges of the21st century. A systemic shift in the food sector can be accelerated by technologies and innovations,such as seaweed food applications. However, introducing and expanding seaweed as a food resourceinto Western markets comes with several challenges.These challenges include its microbial, chemical, and sensory qu
Background: Well-developed vocabulary skills are crucial for academic success. Students having the language of instruction as a second language and students from lower socioeconomic backgrounds often have lower performance on vocabulary assessments. Teachers play an important role in supporting the vocabulary development of all students, regardless of background and educational needs.Aims: To inve
Whenever a material object is selected to represent a physically absent, but emotionally present referent, such as a religious figure or a deceased relative, we have a complex representation situation that involves what we could tentatively label “transgressive cognitive acts”. A transgressive cognitive act is here meant to involve a part that is experienced as present, and as having an effect, bu
Popular Abstract in Swedish De perifera nervstammarna i extremiteterna förmedlar signaler, dels till muskler, dels från känselkroppar som är belägna i bl a huden. Nervstammarna kan av olika orsaker utsättas för skador orsakade av vassa eller skärande föremål eller av olika typer av slitvåld. Nervskador ger ett mycket stort handikapp för den enskilde patienten som förlorar muskelfunktion och känselNerve injuries have a profound impact on individuals, suffering for the patients and induce cost for society. When dealing with severe nerve injuries that create a gap between nerve segments or when the injury is at the brachial plexus level, the clinical alternatives are limited. The brachial plexus model and its branches in the forelimb was evaluated as an experimental model for studies of nerve
Popular Abstract in Swedish Avregleringen av elmarknaden uppmuntrar kraftbolag och oberoende kraftproducenter till att driva sina kraftverksanläggningar på ett marknadsorienterat sätt. För att behålla de ekonomiska marginalerna på plussidan så har de mest populära åtgärderna varit att förbättra elverkningsgraden genom ändringar i hårdvaran samt höja totalverkningsgraden genom till exempel samproduThe deregulation of the electricity market drives utilities and independent power producers to operate heat and power plants as profit centers. In order to keep the economic margins on the credit side, the preferred measures have been to improve the electrical efficiency through changes in the hardware and boost the overall efficiency through e.g. combined heat and power (CHP) generation. The bett
This thesis covers aspects of the mature human B cell and its different guises on its way to become a fully differentiated antibody forming plasma cell (AFC), the key player in the humoral immune system. The understanding of the complex molecular mechanisms taking place in the B cell, as it first encounters antigen, enters the germinal center (GC) reaction, giving rise to memory cells and plasma c
Popular Abstract in Swedish Transplantation av lungor är ett relativt nytt behandlingsalternativ vid svår lung-sjukdom. Den första lungtransplantationen på människa gjordes 1963. Patienten dog efter 18 dagar i njursvikt. Mellan 1963 och 1980 gjordes ca 40 lungtransplantationer i världen med nedslående resultat. Medianöverlevnaden var enbart 8,5 dagar och den patient som levde längst levde bara 6 mDuring the past 15 years lung transplantation has been established as a therapeutic option for patients with end-stage pulmonary disease. The results have improved over time and some transplantation centers now show 1-year survival rates above 80%. The number of donors has remained relatively constant during later years but the demand is increasing resulting in longer waiting times and an increasi
The plants in the ancient Roman garden were chosen with deliberation. These choices were ruled by the meaning and associations the plants conveyed to the garden visitors. Through a close reading of Latin literature and epigraphic sources (used here for the first time in relation to Roman gardens), as well as an examination of the archaeological record from Campanian garden excavations, I deal with
This article deals with the view on death and cure of dying persons in Scandinavia from the middle of the 19th century up to the present. In this period, there is a change from a Christian understanding of death as a transition to eternal life to the present, secularised attitude. This development was, however, not clear-cut. There was a trend towards secularisation but at the same time, there wer
Category housing is an example of forms of housing that belong to the organized work of providing residences for persons who for diverse reasons cannot obtain them on the ordinary housing market. In the organizing of the practical social work that is carried out for this purpose, categorization serves as an important tool for connecting the available housing alternatives with the individuals who s
Popular Abstract in Swedish Årligen diagnostiseras cirka 60 000 nya fall av cancer i Sverige (Socialstyrelsen, 2015), och var tredje person beräknas få en cancerdiagnos under sin livstid. Trots stora framsteg inom forskning och utveckling är cancer, näst efter hjärt- och kärlsjukdomar, den vanligaste dödsorsaken i vårt samhälle. Bland de tio vanligaste formerna av cancer hör lymfom, vilket är etMantle cell lymphoma (MCL) is an aggressive form of B-cell lymphoma (BCL) with poor clinical outcome. In this thesis, which is based upon five original papers, different approaches have been used to pinpoint and investigate molecular events that promote MCL tumor growth, progression or resistance to treatment. The aim has been to identify novel targets with the potential to eradicate malignant cel
A model for evolution of cracks as a result of strain-assisted corrosion is presented. The considered cracks possess a realistic geometry, where the tip region is an integral part of the crack surface instead of being a singular point. This geometry is either implicitly defined or is a consequence of crack nucleation from surface irregularities. The evolution model poses a moving boundary value pr
Popular Abstract in Swedish Bakgrund: Diabetes är en sjukdom som karakteriseras av kroniskt förhöjt blodsocker och som obehandlad kan leda till svåra komplikationer i blodkärl, ögon, njurar, nerver m.m. Sjukdomen beror på kroppens oförmåga att producera (typ 1 diabetes) eller svara på effekt av (typ 2 diabetes) hormonet insulin. Det finns ca 150 miljoner personer med diabetes i världen idag, och sType 2 diabetes is characterised by defects in insulin sensitivity, insulin secretion and increased endogenous glucose production. The relative contribution of each of these defects remains controversial. In order to characterise the metabolic defects in various stages of glucose tolerance, the insulin sensitivity and insulin secretion was measured in a large population based study in Finland and
